IgE Antibody Measurements in Ragweed Hay Fever RELATIONSHIP TO CLINICAL SEVERITY AND THE RESULTS OF IMMUNOTHERAPY

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Abstract

Specific IgE anti-ragweed antibodies (IgEAR) were measured over two years in two groups of highly sensitive patients treated (immunized) with either ragweed extract or placebo and in a third group of placebo-treated, relatively insensitive patients. The IgEAR on the patients' basophils were assessed by ragweed antigen E (AgE)-induced histamine release; blocking (IgG) antibodies were measured by their ability to inhibit AgE induced histamine release. These data were evaluated against the clinical severity of ragweed hay fever in each patient.

Authors

L. M. Lichtenstein, K. Ishizaka, P. S. Norman, A. K. Sobotka, B. M. Hill