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Citations to this article

The Role of Iron in the Pathogenesis of Porphyria Cutanea Tarda: AN IN VITRO MODEL
J. P. Kushner, … , G. R. Lee, S. Nacht
J. P. Kushner, … , G. R. Lee, S. Nacht
Published December 1, 1972
Citation Information: J Clin Invest. 1972;51(12):3044-3051. https://doi.org/10.1172/JCI107131.
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The Role of Iron in the Pathogenesis of Porphyria Cutanea Tarda: AN IN VITRO MODEL

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Abstract

Porphyria cutanea tarda (PCT) is characterized biochemically by excessive hepatic synthesis and urinary excretion of uroporphyrin I. Clinical evidence has implicated iron in the pathogenesis of PCT. The synthesis of the normally occurring isomer of uroporphyrin, namely uroporphyrin III, from porphobilinogen (PBG) requires two enzymes; uroporphyrinogen I synthetase and uroporphyrinogen III cosynthetase (COSYN). In the absence of COSYN only uroporphyrinogen I is formed.

Authors

J. P. Kushner, G. R. Lee, S. Nacht

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Total citations by year

Year: 2011 2007 2003 1999 1998 1997 1993 1992 1989 1988 1987 1986 1985 1984 1983 1982 1981 1980 1979 1978 1977 1976 1975 1974 1959 Total
Citations: 1 2 1 1 1 1 1 1 2 2 1 3 1 1 4 2 5 2 3 4 5 2 1 3 1 51
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (51)

Title and authors Publication Year
Uroporphyria in the Cyp1a2-/- mouse
JD Phillips, JP Kushner, HA Bergonia, MR Franklin
Blood cells, molecules & diseases 2011
Hepatic Iron Quantitation and Its Relationship with Disease Measures and Histologically Assessed Iron Content
S Sajjad, M Garcia, A Malik, DH Thiel
Digestive Diseases and Sciences 2007
Hepatic iron quantitation and its relationship with disease measures and histologically assessed iron content.
Sajjad S, Garcia M, Malik A, Van Thiel DH
Digestive Diseases and Sciences 2007
The Porphyrin Handbook
PM Shoolingin-Jordan
The Porphyrin Handbook 2003
Comprehensive Natural Products Chemistry
LJ Marnett, DC Goodwin, SW Rowlinson, AS Kalgutkar, LM Landino
Comprehensive Natural Products Chemistry 1999
Normal and Abnormal Heme Biosynthesis. 2. 1 Synthesis and Metabolism of Type-III Pentacarboxylic Porphyrinogens: Further Experimental Evidence for the Enzymic Clockwise Decarboxylation of Uroporphyrinogen-III
TD Lash, UN Mani, EA Lyons, P Thientanavanich, MA Jones
The Journal of Organic Chemistry 1998
Tissue-Specific Regulation of Iron Metabolism and Heme Synthesis: Distinct Control Mechanisms in Erythroid Cells
P Ponka
Blood 1997
Purification and properties of the uroporphyrinogen decarboxylase from Rhodobacter sphaeroides
RM Jones, PM Jordan
Biochemical Journal 1993
Ergebnisse der Inneren Medizin und Kinderheilkunde/Advances in Internal Medicine and Pediatrics
M Brandis, A Fanconi, P Frick, K Kochsiek, EO Riecken
1992
Mechanism of iron potentiation of hepatic uroporphyria: Studies in cultured chick embryo liver cells
HL Bonkovsky
Hepatology 1989
8 The clinical manifestations of chronic iron overload
CE Halliday, JW Halliday, LW Powell
Baillière's Clinical Haematology 1989
Association between Alcoholism and Increased Hepatic Iron Stores
MG Irving, JW Halliday, LW Powell
Alcoholism, clinical and experimental research 1988
Porphyria Cutanea Tarda and Porphyria-Like Bullous Dermatoses Associated with Chronic Hemodialysis
MB Poh-Fitzpatrick
Seminars in Dialysis 1988
Hepatic heme synthesis in a new model of experimental hemochromatosis: Studies in rats fed finely divided elemental iron
HL Bonkovsky, JF Healey, B Lincoln, BR Bacon, DF Bishop, GH Elder
Hepatology 1987
Mechanistic studies of the inhibition of hepatic uroporphyrinogen decarboxylase in C57BL/10 mice by iron-hexachlorobenzene synergism
AG Smith, JE Francis, SJ Kay, JB Greig, FP Stewart
Biochemical Journal 1986
Porphyria cutanea tarda, or the uroporphyrinogen decarboxylase deficiency diseases
GD Sweeney
Clinical Biochemistry 1986
Porphyria Cutanea Tarda
ME Grossman, MB Poh-Fitzpatrick
Dermatologic Clinics 1986
Stimulation of 5-aminolevulinic acid metabolism by uroporphyryinogen I in rat liver homogenate
A Shivji, M Bernstein
Clinical Biochemistry 1985
Dual mechanism of inhibition of rat liver uroporphyrinogen decarboxylase activity by ferrous iron: Its potential role in the genesis of porphyria cutanea tarda
SK Mukerji, NR Pimstone, M Burns
Gastroenterology 1984
The Porphyrias
SW Eubanks, JW Patterson, DL May, JL Aeling
International Journal of Dermatology 1983
Hepatic pathology in porphyria cutanea tarda
JH Lefkowitch, ME Grossman
Liver 1983
Developmental aspects of hepatic heme biosynthetic capability and hematotoxicity—II. Studies on uroporphyrinogen decarboxylase
JS Woods, RM Kardish
Biochemical Pharmacology 1983
Effects of Phlebotomy on Urinary Porphyrin Pattern and Liver Histology in Patients with Porphyria Cutanea Tarda
CD Padova, L Marchesi, T Cainelli, G Gori, SA Podenzani, P Rovagnati, M Rizzardini, L Cantoni
The American Journal of the Medical Sciences 1983
Rat hepatic uroporphyrinogen III cosynthase: Purification, properties, and inhibition by metal ions
RP Clement, M Kohashi, WN Piper
Archives of Biochemistry and Biophysics 1982
Pathology of a Black African Population
C Isaacson
1982
The Effect of Ethanol on Heme and Porphyrin Synthesis
JW Ostroff
Alcoholism, clinical and experimental research 1981
Treatment of the Porphyrias: Mechanisms of Action
DR Bickers
Journal of Investigative Dermatology 1981
Conversion of 5-aminolaevulinate into haem by liver homogenates. Comparison of rat and chick embryo
JF Healey, HL Bonkowsky, PR Sinclair, JF Sinclair
Biochemical Journal 1981
Iron and the liver. Acute and long-term effects of iron-loading on hepatic haem metabolism
HL Bonkowsky, JF Healey, PR Sinclair, JF Sinclair, JS Pomeroy
Biochemical Journal 1981
Studies on the action of porphyrinogenic trace metals on the activity of hepatic uroporphyrinogen decarboxylase
JS Woods, R Kardish, BA Fowler
Biochemical and Biophysical Research Communications 1981
Hemochromatosis-newer concepts: Diagnosis and management
ML Bassett, JW Halliday, LW Powell
Disease-a-Month 1980
Porphyria Cutanea Tarda: Diagnosis and Management
ME Grossman, MB Poh-Fitzpatrick
Medical Clinics of North America 1980
PORPHYRIA CUTANEA TARDA
JE Muhlbauer, MA Pathak
International Journal of Dermatology 1979
Skin diseases in Zambia
AV Ratnam, K Jayaraju
British Journal of Dermatology 1979
Hepatic heme metabolism and its control
HL Bonkowsky, PR Sinclair, JF Sinclair
The Yale journal of biology and medicine 1979
Porphyria Cutanea Tarda in Two Patients Treated with Hemodialysis for Chronic Renal Failure
MB Poh-Fitzpatrick, N Bellet, VA DeLeo, ME Grossman, DR Bickers
New England Journal of Medicine 1978
Decreased Activity of Hepatic Uroporphyrinogen Decarboxylase in Sporadic Porphyria Cutanea Tarda
GH Elder, GB Lee, JA Tovey
New England Journal of Medicine 1978
Porphyria Cutanea Tarda in Three Generations of a Single Family
AV Benedetto, JP Kushner, JS Taylor
New England Journal of Medicine 1978
Heme and Hemoproteins
F Matteis, WN Aldridge
1978
ENZYME DEFICIENCIES IN THE PORPHYRIAS
S Kramer, DM Becker, JD Viljoen
British Journal of Haematology 1977
Porphyrin biosynthesis from porphobilinogen by duck blood hemolysate
RB Frydman, B Frydman, G Feinstein
Molecular and Cellular Biochemistry 1977
Haemophilia, hepatitis and porphyria
J Burnett, J Lamon, J Levin
British Journal of Dermatology 1977
Hepatic porphyrias current concepts
JR Walsh
Postgraduate Medicine 1977
Porphyrin biosynthesis from prophobilinogen by duck blood hemolysate.
Frydman RB, Frydman B, Feinstein G
Molecular and Cellular Biochemistry 1977
An inherited enzymatic defect in porphyria cutanea tarda: decreased uroporphyrinogen decarboxylase activity
JP Kushner, AJ Barbuto, GR Lee
Journal of Clinical Investigation 1976
The Hepatic Porphyrias
JR Bloomer
Gastroenterology 1976
The role of iron in the pathogenesis of porphyria cutanea tarda. II. Inhibition of uroporphyrinogen decarboxylase
JP Kushner, DP Steinmuller, GR Lee
Journal of Clinical Investigation 1975
Experimental hepatic porphyria induced by polychlorinated biphenyls
JA Goldstein, P Hickman, DL Jue
Toxicology and Applied Pharmacology 1974
Uroporphyrin formation induced by chlorinated hydrocarbons (lindane, polychlorinated biphenyls, tetrachlorodibenzo-p-dioxin). Requirements for endogenous iron, protein synthesis and drug-metabolizing activity
PR Sinclair, S Granick
Biochemical and Biophysical Research Communications 1974
Iron Storage Disorders of the Liver
ND Grace, LW Powell
Gastroenterology 1974
Porphyria cutanea tarda
H Ippen
Archiv f�r Klinische und Experimentelle Dermatologie 1959

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