A collagenolytic system produced by primary cultures of rheumatoid nodule tissue

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Abstract

A collagenase and a neutral protease have been insolated and characterized from primary cultures obtained from rheumatoid subcutaneous nodules. Release of both active enzymes was maximal between the 3rd and 7th days of culture and was stimulated by the presence of small amounts of colchicine (0.1 μg/ml) added to the culture medium.

Authors

Edward D. Harris Jr.