Studies on the Response of Patients with Classic Hemophilia to Transfusion with Concentrates of Antihemophilic Factor: A DIFFERENCE IN THE HALF-LIFE OF ANTIHEMOPHILIC FACTOR AS MEASURED BY PROCOAGULANT AND IMMUNOLOGIC TECHNIQUES

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Abstract

Antihemophilic factor (AHF, factor VIII) levels were measured by a standard coagulation method and by an immunologic technique before and after infusion of AHF concentrates into patients with classic hemophilia. After infusion of AHF concentrates, the half-life of the AHF procoagulant (i.e., clot-promoting) activity varied from 12 to 14 hr, whereas that of the antigen ranged from 24 to 40 hr. The half-life of the antigen was similar in patients with and without circulating anticoagulants to AHF. The data are compatible with the suggestion that the antigen may be carried on a precursor molecule which the patient with hemophilia produces but cannot convert to the functional clot-promoting agent. Other explanations of the observations are, however, recognized.

Authors

Bruce Bennett, Oscar D. Ratnoff