We tested the ability of human neutrophils to kill five Candida species and the yeast Torulopsis glabrata. C. parapsilosis and C. pseudotropicalis were found to be killed readily by normal and myeloperoxidase-deficient neutrophils and were selected to probe the myeloperoxidase-independent fungicidal mechanisms of the neutrophil.
Robert I. Lehrer
Title and authors | Publication | Year |
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The formation and function of the neutrophil phagosome
Naish E, Wood AJ, Stewart AP, Routledge M, Morris AC, Chilvers ER, Lodge KM |
Immunological Reviews | 2022 |
Intravital Imaging Reveals Divergent Cytokine and Cellular Immune Responses to Candida albicans and Candida parapsilosis
LS Archambault, D Trzilova, S Gonia, C Gale, RT Wheeler, A Gacser, B Hube |
mBio | 2019 |
Candida parapsilosis : from Genes to the Bedside
R Tóth, J Nosek, HM Mora-Montes, T Gabaldon, JM Bliss, JD Nosanchuk, SA Turner, G Butler, C Vágvölgyi, A Gácser |
Clinical microbiology reviews | 2019 |
ERG11 couples oxidative stress adaptation, hyphal elongation and virulence in Candida albicans
YQ Wu, MY Wu, YY Wang, YS Chen, J Gao, CM Ying |
FEMS Yeast Research | 2018 |
Impaired killing of Candida albicans by granulocytes mobilized for transfusion purposes: a role for granule components
RP Gazendam, A de Geer, JL van Hamme, AT Tool, DJ van Rees, CE Aarts, M Biggelaar, F Alphen, P Verkuijlen, AB Meijer, H Janssen, D Roos, TK van Berg, TW Kuijpers |
Haematologica | 2016 |
Beyond Candida albicans: Mechanisms of immunity to non-albicans Candida species
N Whibley, SL Gaffen |
Cytokine | 2015 |
Assessment of Myeloperoxidase Activity by the Conversion of Hydroethidine to 2-Chloroethidium
GJ Maghzal, KM Cergol, SR Shengule, C Suarna, D Newington, AJ Kettle, RJ Payne, R Stocker |
The Journal of biological chemistry | 2014 |
New insights into innate immune control of systemic candidiasis
MS Lionakis |
Medical Mycology | 2014 |
Editorial: Of Mice and Men-Yet Again
H Rosen |
Journal of leukocyte biology | 2013 |
α-Defensins in human innate immunity : α-Defensins
RI Lehrer, W Lu |
Immunological Reviews | 2011 |
Reply
J Bommer, T Heinrich, H Heidt, V Hafner, E Jenetzky, I Walter-Sack, G Mikus |
Nephrology Dialysis Transplantation | 2008 |
Handbook on Hyperbaric Medicine
D Mathieu |
2006 | |
Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E
A Gullo |
2001 | |
Neutrophil function in workers exposed to organophosphate and carbamate insecticides
ML Queiroz, MD Fernandes, MC Valadares |
International Journal of Immunopharmacology | 1999 |
Phagocytosis of medically important yeasts by polymorphonuclear leukocytes
CA Lyman, TJ Walsh |
Infection and immunity | 1994 |
Engulfment and killing capabilities of neutrophils and phagocytic splenic function in persons occupationally exposed to lead
ML Queiroz, FF Costa, C Bincoletto, RC Perlingeiro, DC Dantas, MP Cardoso, M Almeida |
International Journal of Immunopharmacology | 1994 |
Polymorphonuclear phagocytosis and killing in workers exposed to inorganic mercury
RC Perlingeiro, ML Queiroz |
International Journal of Immunopharmacology | 1994 |
Mechanism of Intracellular Candidacidal Activity Mediated by Calcium Ionophore in Human Alveolar Macrophages
A Vecchiarelli, M Dottorini, C Cociani, D Pietrella, T Todisco, F Bistoni |
American journal of respiratory cell and molecular biology | 1993 |
Fungal Infections and Immune Responses
JW Murphy, H Friedman, M Bendinelli |
1993 | |
Ergebnisse der Inneren Medizin und Kinderheilkunde/Advances in Internal Medicine and Pediatrics
M Brandis, A Fanconi, P Frick, K Kochsiek, EO Riecken |
1992 | |
Mononuclear Phagocytes
R van Furth |
1992 | |
Current Topics in Medical Mycology
M Borgers, R Hay, MG Rinaldi |
1992 | |
Neonatal Candidiasis: The Current Challenge
JE Baley |
Clinics in Perinatology | 1991 |
Phagocyte-mediated killing of Candida tropicalis
RA Lindemann, CK Franker |
Mycopathologia | 1991 |
Fungal Infections in HIV Patients
CH Kirkpatrick |
Annals of the New York Academy of Sciences | 1990 |
Experimental pathogenicity and acid proteinase secretion of vaginal isolates ofCandida parapsilosis
FD Bernardis, L Morelli, T Ceddia, R Lorenzini, A Cassone |
Medical Mycology | 1990 |
Effect of Friend leukemia virus infection on susceptibility to Candida albicans
MA Moors, SM Jones, KK Klyczek, TJ Rogers, HR Buckley, KJ Blank |
Infection and immunity | 1990 |
Effects of neutrophils and in vitro oxidants on survival and phenotypic switching of Candida albicans WO-1
MP Kolotila, RD Diamond |
Infection and immunity | 1990 |
Mycoses in AIDS Patients
HV Bossche, DW Mackenzie, G Cauwenbergh, JV Cutsem, E Drouhet, B Dupont |
1990 | |
Chronic mucocutaneous candidiasis
CH Kirkpatrick |
European Journal of Clinical Microbiology & Infectious Diseases | 1989 |
Systemic candidosis in beige mice
A Baghian, KW Lee |
Medical Mycology | 1989 |
Oral Candida albicans isolates from nonhospitalized normal carriers, immunocompetent hospitalized patients, and immunocompromised patients with or without acquired immunodeficiency syndrome
DL Brawner, JE Cutler |
Journal of clinical microbiology | 1989 |
Modulation of the in vitro candidacidal activity of human neutrophil defensins by target cell metabolism and divalent cations
RI Lehrer, T Ganz, D Szklarek, ME Selsted |
Journal of Clinical Investigation | 1988 |
The bactericidal effects of the respiratory burst and the myeloperoxidase system isolated in neutrophil cytoplasts
EW Odell, AW Segal |
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 1988 |
Pentamidine isethionate-induced neutrophil dysfunction
MA Arnott, J Hay, SL Croft |
Annals of Tropical Medicine and Parasitology | 1988 |
Myeloperoxidase Deficiency
WM Nauseef |
Hematology/Oncology Clinics of North America | 1988 |
Host-Parasite Relationship in Opportunistic Mycoses
AR Waldorf |
Critical Reviews in Microbiology | 1986 |
Metabolic activity of phagocytes in experimental sporotrichosis
R Ramos-Zepeda, A Gonzlez-Mendoza |
Mycopathologia | 1986 |
Defensins. Natural peptide antibiotics of human neutrophils
T Ganz, ME Selsted, D Szklarek, SS Harwig, K Daher, DF Bainton, RI Lehrer |
Journal of Clinical Investigation | 1985 |
Activity of rabbit leukocyte peptides against Candida albicans
ME Selsted, D Szklarek, T Ganz, RI Lehrer |
Infection and immunity | 1985 |
Pathogenicity of morphological and auxotrophic mutants of Candida albicans in experimental infections
MG Shepherd |
Infection and immunity | 1985 |
Studies on Granulocyte Functions in Patients with Chronic Myeloid Leukemia
PN Anklesaria, SH Advani, AN Bhisey |
TUMORI | 1985 |
Variability in expression of a cell surface determinant on Candida albicans as evidenced by an agglutinating monoclonal antibody
DL Brawner, JE Cutler |
Infection and immunity | 1984 |
Regulation of Leukocyte Function
R Snyderman |
1984 | |
Combined neutrophil and T-cell deficiency
E Silverman, J Bargman |
The American Journal of Medicine | 1983 |
The enhancement of eosinophil function by lymphocyte supernatants
R Sher, A Wadee, M Joffe |
Clinical & Experimental Immunology | 1983 |
Iodination by stimulated human neutrophils. Studies on its stoichiometry, subcellular localization and relevance to microbial killing
AW Segal, RC Garcia, AM Harper, JP Banga |
Biochemical Journal | 1983 |
Candida esophagitis
R Mathieson, SK Dutta |
Digestive Diseases and Sciences | 1983 |
Enhanced antibody responses induced by Candida albicans in mice
JE Cutler, RK Lloyd |
Infection and immunity | 1982 |
Microbicidal Activity of Bone Marrow Cells. Augmentation of Candida Killing Activity of the Cells by Culturing with Fibroblast Conditioned Medium
RT Nozawa, T Yokota |
Microbiology and Immunology | 1982 |
Iodination catalyzed by the xanthine oxidase system: role of hydroxyl radicals
SJ Klebanoff |
Biochemistry | 1982 |
Effects of surgery on neutrophil granulocyte function
H El-Maallem, J Fletcher |
Infection and immunity | 1981 |
Defective Aspergillus killing by neutrophil leucocytes in a case of systemic aspergillosis
A Pagani, R Spalla, FA Ferrari, M Duse, L Lenzi, U Bretz, M Baggiolini, AG Siccardi |
Clinical & Experimental Immunology | 1981 |
Immunology of Human Infection
AJ Nahmias, RJ OReilly |
1981 | |
In vitro phagocytosis of Candida albicans by peritoneal mouse macrophages
R Evron |
Infection and immunity | 1980 |
Immunity to Candida albicans
TJ Rogers, E Balish |
Microbiological reviews | 1980 |
Fungicidal activity of rabbit alveolar and peritoneal macrophages against Candida albicans
RI Lehrer, LG Ferrari, J Patterson-Delafield, T Sorrell |
Infection and immunity | 1980 |
Macrophage microbicidal activity. Correlation between phagocytosis-associated oxidative metabolism and the killing of Candida by macrophages
M Sasada, RB Johnston |
Journal of Experimental Medicine | 1980 |
Oxidativer Metabolismus von Phagozyten: Physikochemische Grundlagen und klinische Relevanz
LH Block, R Lthy, W Siegenthaler |
Klinische Wochenschrift | 1980 |
Effect of bilirubin on the fungicidal capacity of human neutrophils
YH Thong, D Ness, A Ferrante |
Medical Mycology | 1979 |
Interactions between human granulocytes and Blastomyces dermatitidis
JW Sixbey, BT Fields, CN Sun, RA Clark, CM Nolan |
Infection and immunity | 1979 |
Mechanisms of Attachment of Neutrophils to Candida albicans Pseudohyphae in the Absence of Serum, and of Subsequent Damage to Pseudohyphae by Microbicidal Processes of Neutrophils In Vitro
RD Daimond, R Krzesicki |
Journal of Clinical Investigation | 1978 |
Tierexperimentelle Untersuchungen zur Immunität bei der Infektion mit Candida albicans (2. Fortsetzung und Schluß)
K Fegeler, E Macher, S Nolting |
Mycoses | 1978 |
Phagocytosis: A Review
MN Walters, JM Papadimitriou, WG Spector |
Critical Reviews in Toxicology | 1978 |
The in vitro interactions of candida albicans with nonspecific serum proteins
HF Hasenclever |
Mycopathologia | 1978 |
Susceptibility of lipopolysaccharide mutants to the bactericidal action of human neutrophil lysosomal fractions
RF Rest, MH Cooney, JK Spitznagel |
Infection and immunity | 1977 |
Fungicidal properties of a chymotrypsin-like cationic protein from human neutrophils: adsorption to Candida parapsilosis
RE Drazin, RI Lehrer |
Infection and immunity | 1977 |
Microbial surfaces in relation to pathogenicity
H Smith |
Bacteriological reviews | 1977 |
A simple microscopic method for identifying and quantitating phagocytic cells in vitro
J Patterson-Delafield, RI Lehrer |
Journal of Immunological Methods | 1977 |
Disseminated candidiasis in a previously healthy girl: Implication of a leukocyte candidacidal defect
PJ Staples, J Boujak, RG Douglas, JP Leddy |
Clinical Immunology and Immunopathology | 1977 |
The Clinical and Laboratory Diagnosis of Chronic Granulomatous Disease of Childhood
BR Macpherson |
Critical Reviews in Clinical Laboratory Sciences | 1977 |
The Year in Hematology
AS Gordon, R Silber, J LoBue |
1977 | |
Defective Neutrophil Function in Chronic Granulocytic: Leukaemia
H EL-MAALEM, J Fletcher |
British Journal of Haematology | 1976 |
Function of Granulocytes with Deficient Myeloperoxidase-Mediated Iodination in a Patient with Generalized Pustular Psoriasis
O Stendahl, S Lindgren |
Scandinavian Journal of Haematology | 1976 |
Phagocytose et Candida
JL Vildé |
Revue Française d'Allergologie et d'Immunologie Clinique | 1976 |
Opportunistic Invasive Fungal Infections in Patients with Leukaemia and Lymphoma
JA Krick, JS Remington |
Clinics in Haematology | 1976 |
The fungicidal mechanisms of human monocytes. I. Evidence for myeloperoxidase-linked and myeloperoxidase-independent candidacidal mechanisms
RI Lehrer |
Journal of Clinical Investigation | 1975 |
Antibacterial activity of cationic proteins from human granulocytes
H Odeberg, I Olsson |
Journal of Clinical Investigation | 1975 |
Partial Myeloperoxidase Deficiency in a Case of Preleukaemia
J Breton-Gorius, D Houssay, B Dreyfus |
British Journal of Haematology | 1975 |
Efectos de la fagocitosisin vitrosobre elParacoccidioides brasiliensis
AR M, H Y, V A |
Medical Mycology | 1975 |
Nonoxidative fungicidal mechanisms of mammalian granulocytes: demonstration of components with candidacidal activity in human, rabbit, and guinea pig leukocytes
RI Lehrer, KM Ladra, RB Hake |
Infection and immunity | 1975 |
Microbe Ingestion and Killing by Neutrophils: Normal Mechanisms and Abnormalities
RL Baehner |
Clinics in Haematology | 1975 |
Torulopsis glabrata renal infection
CA Kauffman, JS Tan |
The American Journal of Medicine | 1974 |
Granulocytopathies
PG Quie, HR Hill |
Disease-a-Month | 1973 |