Citations to this article

Effects of Androgen Treatment on the Male Rat Aorta
Harvey Wolinsky
Harvey Wolinsky
Published October 1, 1972
Citation Information: J Clin Invest. 1972;51(10):2552-2555. https://doi.org/10.1172/JCI107071.
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Research Article

Effects of Androgen Treatment on the Male Rat Aorta

Abstract

Androgen was given to male rats to determine if it exerted effects on the aortic wall distinct from those of estrogen deficit. Although a general anabolic effect was avoided, significant vascular effects were observed. The amounts of mural fibrous proteins, elastin and collagen, were significantly increased in treated animals; noncollagenous, alkali-soluble protein, thought to reflect the cellular component, was unchanged with treatment. These effects were not detectable on microscopic examination and measurement of the vessel wall despite attempts to duplicate closely in vivo wall dimensions before study. These findings of distinct and marked effects of androgen on vascular metabolism extend the growing evidence for an important role of sex hormones in vessel wall structure and function.

Authors

Harvey Wolinsky

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Year: 2023 2017 2016 1996 1994 1993 1992 1991 1987 1986 1985 1982 1981 1979 1976 1975 1974 1973 1959 Total
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Citations to this article (26)

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Effect of Gender and Sex Steroids on the Contractile Response of Canine Coronary and Renal Blood Vessels
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ED Lehmann, KD Hopkins, JR Parker, RC Turay, J Rymer, I Fogelman, RG Gosling 		British Journal of Radiology 1994
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P Buttrick, J Scheuer 		Circulation 1992
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PW Ramwell, GM Rubanyi, E Schillinger 		1992
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GS Ferenchick 		Medical Hypotheses 1991
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JM Foidart, ER Savolainen, P Carlier, D Gillain, B Nusgens, G Rorive, CM Lapière 		Clinical and Experimental Hypertension. Part B: Hypertension in Pregnancy 1985
Canine vascular tissues are targets for androgens, estrogens, progestins, and glucocorticoids
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Effect of gender on development and diurnal rhythm of prostaglandin receptors in rat aorta
JW Karanian, ER Ramey, PW Ramwell 		British Journal of Pharmacology 1981
EFFECT OF GENDER ON DEVELOPMENT AND DIURNAL RHYTHM OF PROSTAGLANDIN RECEPTORS IN RAT AORTA
J Karanian, E Ramey, P Ramwell 		British Journal of Pharmacology 1981
Androgens regulate cell growth, lysosomal hydrolases and mitochondrial cytochrome c oxidase in mouse aorta
AD Goldstone, H Koenig, CY Lu 		Biochimica et Biophysica Acta (BBA) - General Subjects 1981
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