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The effect of steroids and ammonium chloride acidosis on phosphoenolpyruvate carboxykinase in rat kidney cortex: I. Differentiation of the inductive processes and characterization of enzyme activities
I. D. Longshaw, C. I. Pogson
I. D. Longshaw, C. I. Pogson
Published September 1, 1972
Citation Information: J Clin Invest. 1972;51(9):2277-2283. https://doi.org/10.1172/JCI107037.
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The effect of steroids and ammonium chloride acidosis on phosphoenolpyruvate carboxykinase in rat kidney cortex: I. Differentiation of the inductive processes and characterization of enzyme activities

Abstract

The behaviour of rat kidney cortex phosphoenolpyruvate carboxykinase has been investigated under conditions of triamcinolone administration and ammonium chloride acidosis. The concentration of phosphoenolpyruvate carboxykinase as measured by enzyme activity and immunotitration was elevated under both conditions. The mechanism of induction is different in the two cases. At doses which produce maximum stimulation, the effects of steroid and ammonium chloride were additive; only the increment in enzyme activity produced by steroid was blocked by actinomycin D.

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I. D. Longshaw, C. I. Pogson

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