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Citations to this article

Biliary excretion of lecithin and cholesterol in the dog
Henry O. Wheeler, Katherine K. King
Henry O. Wheeler, Katherine K. King
Published June 1, 1972
Citation Information: J Clin Invest. 1972;51(6):1337-1350. https://doi.org/10.1172/JCI106930.
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Research Article

Biliary excretion of lecithin and cholesterol in the dog

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Abstract

The biliary excretion rates of bile acid, lecithin, and cholesterol were measured in unanesthetized dogs after interruption of enterohepatic circulation and during infusions of sodium taurocholate, sodium glycocholate, sodium dehydrocholate, SC2644 (a bicyclic organic acid with high choleretic potency), and secretin. Both lecithin output and cholesterol output were directly related to bile acid excretion rate. The curves describing these relationships were concave downward. Molar concentration ratios of lecithin-to-bile acid declined gradually from approximately 0.4 to 0.2 as bile acid output increased from approximately 1 to 70 μmoles/min. Cholesterol-to-lecithin molar ratios were highest (0.05-0.15) at very low rates of bile acid excretion, but descended rapidly to a plateau (0.03-0.04) which was constant over the entire range of bile acid excretion rates from 10 to 70 μmoles/min.

Authors

Henry O. Wheeler, Katherine K. King

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Year: 2021 2017 2015 2010 2002 2000 1999 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1984 1983 1982 1981 1980 1979 1978 1977 1976 1975 1974 1973 1972 1965 1962 Total
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