The biliary excretion rates of bile acid, lecithin, and cholesterol were measured in unanesthetized dogs after interruption of enterohepatic circulation and during infusions of sodium taurocholate, sodium glycocholate, sodium dehydrocholate, SC2644 (a bicyclic organic acid with high choleretic potency), and secretin. Both lecithin output and cholesterol output were directly related to bile acid excretion rate. The curves describing these relationships were concave downward. Molar concentration ratios of lecithin-to-bile acid declined gradually from approximately 0.4 to 0.2 as bile acid output increased from approximately 1 to 70 μmoles/min. Cholesterol-to-lecithin molar ratios were highest (0.05-0.15) at very low rates of bile acid excretion, but descended rapidly to a plateau (0.03-0.04) which was constant over the entire range of bile acid excretion rates from 10 to 70 μmoles/min.
Henry O. Wheeler, Katherine K. King
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Biochemical and Biophysical Research Communications | 2000 |
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Lipids | 1999 |
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Gastroenterology | 1989 |
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Biochemical Journal | 1987 |
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1987 | |
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Biochemical Journal | 1986 |
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Gastroenterology | 1986 |
The Effect of Drugs on Bile Flow and Composition: An Overview
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Drugs | 1986 |
Mechanism and kinetic characteristics of the uncoupling by plant steroids of biliary cholesterol from bile salt output
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Acute effects of pentobarbital-anaesthesia on bile secretion
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Composition of Human Hepatic Bile
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Annals of Clinical Biochemistry | 1985 |
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Digestive Diseases and Sciences | 1985 |
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Journal of Clinical Investigation | 1984 |
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The Japanese Journal of Surgery | 1984 |
Biliary Lipid Secretion in Health and in Cholesterol Gallstone Disease
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Hepatology | 1984 |
Insulin's effect on bile flow and lipid excretion during euglycemia and hypoglycemia
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Digestive Diseases and Sciences | 1984 |
Effects of dibutyryl cyclic AMP and theophylline on biliary cholesterol secretion
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Journal of Surgical Research | 1984 |
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Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1984 |
Quasi-elastic light scattering studies of native hepatic bile from the dog: comparison with aggregative behavior of model biliary lipid systems
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Biochemistry | 1984 |
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Gastroenterology | 1984 |
Mathematical model of biliary lipid secretion: a quantitative analysis of physiological and biochemical data from man and other species
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Journal of lipid research | 1984 |
Regulation of hepatic lipoprotein receptors in the dog. Rapid regulation of apolipoprotein B,E receptors, but not of apolipoprotein E receptors, by intestinal lipoproteins and bile acids
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Journal of Clinical Investigation | 1983 |
Mechanism of hepatic bicarbonate secretion and bile acid independent bile secretion
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European Journal of Clinical Investigation | 1983 |
The Effect of Progesterone on the Regulatory Mechanisms of Biliary Cholesterol Secretion in the Rat
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Steroids | 1983 |
DISPERSION OF CHOLESTEROL IN AQUEOUS SURFACTANT SOLUTIONS: INTERPRETATION OF VISCOSITY DATA
VS Singh, RC Gaur |
Journal of dispersion science and technology | 1983 |
Reversal of progesterone-induced biliary cholesterol output by dietary cholesterol and ethynylestradiol
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Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1983 |
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The Journal of biological chemistry | 1983 |
Regulation of bile salt transport in rat liver. Evidence that increased maximum bile salt secretory capacity is due to increased cholic acid receptors
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Journal of Clinical Investigation | 1982 |
Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis part II
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Digestive Diseases and Sciences | 1982 |
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Gastroenterology | 1982 |
Effect of the selective expansion of cholic acid pool on bile lipid composition: Possible mechanism of bile acid induced biliary cholesterol desaturation
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The Journal of biological chemistry | 1981 |
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The Journal of Physiology | 1980 |
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1980 | |
Verhandlungen der Deutschen Gesellschaft für innere Medizin
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1980 | |
Kinetics of the enterohepatic circulation during fasting: Biliary lipid secretion and gallbladder storage
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Gastroenterology | 1980 |
Bile acid metabolism in cirrhosis
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European Journal of Clinical Investigation | 1979 |
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American journal of physiology. Endocrinology and metabolism | 1979 |
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The Japanese Journal of Pharmacology | 1979 |
Effect of Acute Alteratioris in Small Bowel Transit Time upon the Biliary Excretion Rate of Bile Acids
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Gastroenterology | 1979 |
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American journal of physiology. Endocrinology and metabolism | 1978 |
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Choleretic Properties of Ursodeoxycholic Acid and Chenodeoxycholic Acid in Dogs
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The Japanese Journal of Pharmacology | 1978 |
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Gastroenterology | 1978 |
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Biochemical and Biophysical Research Communications | 1977 |
Lipid Metabolism in Mammals
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1977 | |
Bile Secretion in Selective Biliary Obstruction
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Irish Journal of Medical Science | 1977 |
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Journal of Clinical Investigation | 1976 |
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The Journal of Physiology | 1976 |
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1976 | |
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Journal of Clinical Investigation | 1975 |
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Biliary Excretion of Xenobiotics
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Critical Reviews in Toxicology | 1975 |
Choleresis and hepatic transport mechanisms: II. Influence of bile salt choleresis and biliary micelle binding on biliary excretion on various organic anions
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Naunyn-Schmiedeberg's Archives of Pharmacology | 1975 |
Hypolipidemic Agents
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1975 | |
Effect of nafenopin (SU-13,437) on liver function: Mechanism of choleretic effect
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Naunyn-Schmiedeberg's Archives of Pharmacology | 1975 |
Crustacean Intestinal Detergent Promotes Sterol Solubilization
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Science | 1975 |
Studies of the hepatic excretory defects in essential fatty acid deficiency. Their possible relationship to the genesis of cholesterol gallstones
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The goose that laid the golden bile: Gallstone dissolution in man with chenodeoxycholic acid
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Irish Journal of Medical Science | 1974 |
The control of bile acid pool size: effect of jejunal resection and phenobarbitone on bile acid metabolism in the rat
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Gut | 1974 |
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The Japanese Journal of Surgery | 1974 |
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Biochimie | 1974 |
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New England Journal of Medicine | 1974 |
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Medical Clinics of North America | 1974 |
Mechanisms and Control of Secretion of Bile Water and Electrolytes
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Gastroenterology | 1974 |
Canalicular Bile Flow and Bromosulfophthalein Transport Maximum: The Effect of a Bile Salt-Independent Choleretic, Sc-2644
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Gastroenterology | 1974 |
Supersaturated Bile - Is it Due to a Metabolic Disorder or to an Impaired Gallbladder?
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Scandinavian Journal of Gastroenterology | 1974 |
Triketocholanoic (Dehydrocholic) Acid. HEPATIC METABOLISM AND EFFECT ON BILE FLOW AND BILIARY LIPID SECRETION IN MAN
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Journal of Clinical Investigation | 1973 |
Different effects of free and conjugated bile acids and their keto derivatives on (Na+, K+)-stimulated and Mg2+-ATPase of rat intestinal mucosa
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Biochimica et Biophysica Acta (BBA) - Biomembranes | 1973 |
Diurnal Variation in Biliary Lipid Composition: Possible Role in Cholesterol Gallstone Formation
AL Metzger, R Adler, S Heymsfield, SM Grundy |
New England Journal of Medicine | 1973 |
Inhibition of Bilirubin Excretion in Man During Dehydrocholate Choleresis
JR Bloomer, JL Boyer, G Klatskin |
Gastroenterology | 1973 |
Interrelationship of Bile Salts, Phospholipids, and Cholesterol in Bile During Manipulation of the Enterohepatic Circulation in the Conscious Dog
RD Soloway, KM Powell, JR Senior, FP Brooks |
Gastroenterology | 1973 |
Biliary Excretion of Bile Acids, Lecithin, and Cholesterol in Hamsters with Gallstones
HO Wheeler |
Gastroenterology | 1973 |
Mechanisms of Lithogenic Bile Formation in American Indian Women with Cholesterol Gallstones
SM Grundy, AL Metzger, RD Adler |
Journal of Clinical Investigation | 1972 |
Advances in Lipid Research
AM Scanu |
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British medical journal | 1962 |