Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Immunological Studies of Y Protein. A MAJOR CYTOPLASMIC ORGANIC ANION-BINDING PROTEIN IN RAT LIVER
Gerald Fleischner, … , John Robbins, Irwin M. Arias
Gerald Fleischner, … , John Robbins, Irwin M. Arias
Published March 1, 1972
Citation Information: J Clin Invest. 1972;51(3):677-684. https://doi.org/10.1172/JCI106856.
View: Text | PDF
Research Article

Immunological Studies of Y Protein. A MAJOR CYTOPLASMIC ORGANIC ANION-BINDING PROTEIN IN RAT LIVER

  • Text
  • PDF
Abstract

An antibody produced against rat Y protein, the major cytoplasmic organic anion-binding protein in liver, was characterized. The antibody precipitated Y protein from liver supernatant fractions and specifically removed the organic anion-binding capacity from this fraction.

Authors

Gerald Fleischner, John Robbins, Irwin M. Arias

×

Total citations by year

Year: 2014 2011 2006 2000 1995 1994 1991 1989 1988 1987 1986 1985 1984 1983 1982 1981 1980 1979 1978 1977 1976 1975 1974 1973 1962 1960 Total
Citations: 1 2 2 1 2 1 3 1 2 4 2 4 4 4 2 8 7 8 9 10 9 6 3 4 1 1 101
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (101)

Title and authors Publication Year
Comprehensive Physiology
SN Cheuvront, RW Kenefick
Comprehensive Physiology 2014
Advances in Clinical Chemistry
M Mahler
Advances in Clinical Chemistry Volume 54 2011
Advances in Cancer Research
M Lemaire, S Deleu, ED Bruyne, EV Valckenborgh, E Menu, K Vanderkerken
Advances in Cancer Research Volume 110 2011
Advances in Enzymology - and Related Areas of Molecular Biology
H Waelsch
Advances in Enzymology and Related Areas of Molecular Biology 2006
Isolation and characterization of a novel glutathione S-transferase-activating peptide from the oriental medicinal plant Phellodendron amurense
JH Lee, DH Lee, HE Yu, JH Kim, JS Lee
Peptides 2006
Difference in susceptibilities of different cell lines to bilirubin damage
KC Ngai, CY Yeung, CS Leung
Journal of Paediatrics and Child Health 2000
Influence of glutathione S-transferase B (ligandin) on the intermembrane transfer of bilirubin. Implications for the intracellular transport of nonsubstrate ligands in hepatocytes
SD Zucker, W Goessling, BJ Ransil, JL Gollan
Journal of Clinical Investigation 1995
Analysis of tissue distribution of valproate in guinea-pigs: evidence for its capacity-limited tissue distribution
H Y Yu, Y Z Shen
Pharmaceutical Research 1995
Induction of a dose-related increase in sulfobromophthalein uptake velocity in freshly isolated rat hepatocytes by phenobarbital
BJ Potter, JZ Ni, K Wolfe, D Stump, PD Berk
Hepatology 1994
Responsiveness to phenobarbital in an adult with crigler-najjar disease associated with neurological involvement and skin hyperextensibility
M Persico, M Romano, M Muraca
Hepatology 1991
Mutagenicity of 3-chlorodibenzofuran and its metabolic activation
M Matsumoto, M Ando, KE Mortelmans
Environmental and Molecular Mutagenesis 1991
Histochemical and Immunohistochemical Techniques
PH Bach, J Baker
1991
Nephrotoxicity
PH Bach, EA Lock
1989
Serum bilirubin fractions in analbuminemic rats after bile duct ligation
Y Adachi, A Kambe, M Yamashita, H Inufusa, S Nagase, T Yamamoto
Journal of Hepatology 1988
Interaction of organic azides with purified camel glutathione S-transferase
AA Hunaiti, ST Abu-Orabi, MA Sahran, WM Owais
Biochemical Medicine and Metabolic Biology 1988
Isolation of a human liver ligandin cDNA clone and demonstration of seouence homology at ligandin loci in rats and humans
L Butera, JR Monnier, E Campbell, MM Bhargava
Biochemical and Biophysical Research Communications 1987
Membrane Transport Processes in Organized Systems
TE Andreoli, JF Hoffman, DD Fanestil, SG Schultz
1987
Enzymes of glutathione metabolism as biochemical markers during hepatocarcinogenesis
S Hendrich, HC Pitot
Cancer and Metastasis Reviews 1987
Nephrotoxicity in the experimental and clinical situation
PH Bach, EA Lock
1987
Effect of combined treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin and phototherapy on bilirubin metabolism in the jaundiced gunn rat
AN Cohen, J Kapitulnik, JD Ostrow, CC Webster
Hepatology 1986
Urinary Glutathione-S-Transferase in Cisplatin Nephrotoxicity in the Rat
DA Feinfeld, VL Fuh, R Safirstein
Clinical Chemistry and Laboratory Medicine 1986
Immunological studies of an organic anion-binding protein isolated from rat liver cell plasma membrane
AW Wolkoff, A Sosiak, HC Greenblatt, JV Renswoude, RJ Stockert
Journal of Clinical Investigation 1985
The key role of sex dependency on kidney citrate metabolism in the rat
WH Hörl, E Echsel, M Hohenegger
Research in Experimental Medicine 1985
Effects of phenobarbital on bilirubin metabolism and its response to phototherapy in the jaundiced gunn rat
AN Cohen, J Kapitulnik, JD Ostrow, EA Zenone, C Cochrane, L Celic, H Cheney
Hepatology 1985
Transcriptional regulation of rat liver glutathione S-transferase genes by phenobarbital and 3-methylcholanthrene
VD Ding, CB Pickett
Archives of Biochemistry and Biophysics 1985
A Prospective Study of Urinary Ligandin in Patients at Risk of Renal Tubular Injury
RA Sherman, DA Feinfeld, N Ohmi, IM Arias, SD Levine
Renal Failure 1984
Purification and properties of glutathione S-transferases from larvae of Wiseana cervinata
AG Clark, B Drake
Biochemical Journal 1984
Characterization of soluble glutathione transferase activity in resting mononuclear leukocytes from human blood
J Seidegård, JW de Pierre, W Birberg, Å Pilotti, RW Pero
Biochemical Pharmacology 1984
Effects of aging on hepatic and pulmonary glutathione S-transferase activities in male and female fischer 344 rats
ME Spearman, KC Leibman
Biochemical Pharmacology 1984
Hepatic bilirubin uptake in the isolated perfused rat liver is not facilitated by albumin binding
YR Stollman, U Gärtner, L Theilmann, N Ohmi, AW Wolkoff
Journal of Clinical Investigation 1983
Rat ligandin mRNA molecular cloning and sequencing
V Daniel, S Sarid, S Barnun, G Litwack
Archives of Biochemistry and Biophysics 1983
Purification and characterization of a novel abundant protein in rat bile that binds azo dye metabolites and copper
AR Samuels, JH Freedman, MM Bhargava
Biochimica et Biophysica Acta (BBA) - General Subjects 1983
Purification and characterization of corn glutathione S-transferase
TJ Mozer, DC Tiemeier, EG Jaworski
Biochemistry 1983
SPECIES DIFFERENCES IN CYTOCHROMES P450 AND THEIR CORRESPONDING MESSENGER RNA'S
R Makowski, R Davies, GG Gibson
Drug Metabolism and Drug Interactions 1982
Identity of ligandin in rat testis and liver
KA Eidne, RE Kirsch
Biochemical Journal 1982
Ligandinemia in primary liver cell cancer in rat and man
N Ohmi, IM Arias
Hepatology 1981
Tissue distribution and subunit structures of the multiple forms of glutathione S-transferase in the rat
NC Scully, TJ Mantle
Biochemical Journal 1981
Induction by phenobarbital of the mRNA for a specific variant of rat liver microsomal cytochrome P-450
IR Phillips, EA Shephard, F Mitani, BR Rabin
Biochemical Journal 1981
Prediction of cadaver kidney function by ligandin analysis
SI Cho, B Zalneraitis, N Ohmi, IM Arias
Journal of Surgical Research 1981
Improvement of the parallel flow dialysis technique for the detection of drug-binding proteins in column effluents
K Miura, H Nakamura, Z Tamura
Journal of Chromatography A 1981
Induction of translationally active rat liver glutathione S-transferase B messenger RNA by phenobarbital
CB Pickett, W Wells, AY Lu, BF Hales
Biochemical and Biophysical Research Communications 1981
Serum glutathione S-transferase in experimentl liver damage in rats
Y Adachi, K Horii, M Suwa, M Tanihata, Y Ohba, T Yamamoto
Gastroenterologia Japonica 1981
Mechanism of induction of cytochrome P-450 by phenobarbital
M Adesnik, S Bar-Nun, F Maschio, M Zunich, A Lippman, E Bard
The Journal of biological chemistry 1981
Identification, Purification, and Partial Characterization of an Organic Anion Binding Protein from Rat Liver Cell Plasma Membrane
AW Wolkoff, CT Chung
Journal of Clinical Investigation 1980
Immunohistological localization of ligandin in human tissues
JA Campbell, NM Bass, RE Kirsch
Cancer 1980
Subcellular distribution and covalent binding of aflatoxins as functions of dietary manipulation
KD Mainigi, TC Campbell
Journal of Toxicology and Environmental Health 1980
Binding protein for 1-anilino-8-naphthalenesulfonate in rat liver cytoplasm
Y Sugiyama, T iga, S Awazu, M Hanano
Biochemical Pharmacology 1980
Enzymatic Basis of Detoxication
DW Nebert
Enzymatic Basis of Detoxication 1980
Structural, catalytic, binding, and immunological properties associated with each of the two subunits of rat liver ligandin
MM Bhargava, N Ohmi, I Listowsky, IM Arias
The Journal of biological chemistry 1980
Ligandin: An adventure in Liverland
IM Arias, N Ohmi, M Bhargava, I Listowsky
Molecular and Cellular Biochemistry 1980
A fatty acid binding peptide of rat liver cytosol
B Rüstow, D Kunze, J Hodi, E Egger
FEBS Letters 1979
Identification of two lithocholic acid-binding proteins. Separation of ligandin from glutathione S-transferase B
JD Hayes, RC Strange, IW Percy-Robb
Biochemical Journal 1979
The binding and catalytic activities of forms of ligandin after modification of its thiol groups
T Carne, E Tipping, B Ketterer
Biochemical Journal 1979
Intestinal organic anion transport, glutathione transferase and aryl hydrocarbon hydroxylase activity: Effect of dioxin
J Manis, R Apap
Life Sciences 1979
Effect of repeated oral administration of phenobarbitone or DDT on hepatic glutathione S-transferase activity in non-human primates: Comparison with the rat
WH Down, LF Chasseaud
Biochemical Pharmacology 1979
Role of ligandin in transfer of bilirubin from plasma into liver
AW Wolkoff, CA Goresky, J Sellin, Z Gatmaitan, IM Arias
American journal of physiology. Endocrinology and metabolism 1979
Biliary Excretion of Drugs in Man:
DE Rollins, CD Klaassen
Clinical Pharmacokinetics 1979
Radioimmunoassay of ligandin.
Tsuru M
Gastroenterologia Japonica 1979
Hepatic Accumulation and Intracellular Binding of Conjugated Bilirubin
AW Wolkoff, JN Ketley, JG Waggoner, PD Berk, WB Jakoby
Journal of Clinical Investigation 1978
Ligandin retains and albumin loses bilirubin binding capacity in liver cytosol
I Listowsky, Z Gatmaitan, IM Arias
Proceedings of the National Academy of Sciences 1978
Specific binding of saturated and unsaturated fatty acids on the ‘Z’-protein of rat liver cytosol
B Rüstow, J Hodi, D Kunze, G Reichmann, E Egger
FEBS Letters 1978
Quantification of human serum ligandin by radioimmunoassay
M Tsuru, K Kamisaka, M Hirano, H Kameda
Clinica Chimica Acta 1978
Effect of repeated oral administration of isosorbide dinitrate on hepatic glutathione S-transferase activity in the rat
LF Chasseaud, WH Down, RM Sacharin
Biochemical Pharmacology 1978
Physiology of Membrane Disorders
TE Andreoli, JF Hoffman, DD Fanestil
1978
Heme and Hemoproteins
F Matteis, WN Aldridge
1978
Radioimmunoassay of Plasma Ligandin
NM Bass, RE Kirsch, SA Tuff, SJ Saunders
Gastroenterology 1978
Ligandin. Bilirubin binding and glutathione-S-transferase activity are independent processes
MM Bhargava, I Listowsky, IM Arias
The Journal of biological chemistry 1978
Ligandinuria in nephrotoxic acute tubular necrosis
DA Feinfeld, JJ Bourgoignie, G Fleischner, EJ Goldstein, L Biempica, IM Arias
Kidney International 1977
The Preparation of Ligandin with Glutathione-S-Transferase Activity from Porcine Liver Cytosol by Affinity Chromatography on Bromosulphophthalein-Sepharose
A GRAHNEN, I SJOHOLM
European Journal of Biochemistry 1977
Translation in vitro of rat liver messenger RNA coding for ligandin (glutathione S-transferase B)
V Daniel, GJ Smith, G Litwack
Proceedings of the National Academy of Sciences 1977
Ligandin content in liver of rats intoxicated by carbon tetrachloride
PD Simplicio, G Segre
Pharmacological Research Communications 1977
Radioimmunoassay of ligandin
NM Bass, RE Kirsch, SA Tuff, SJ Saunders
Biochimica et Biophysica Acta (BBA) - Protein Structure 1977
Ligandin heterogeneity: Evidence that the two non-identical subunits are the monomers of two distinct proteins
NM Bass, RE Kirsch, SA Tuff, I Marks, SJ Saunders
Biochimica et Biophysica Acta (BBA) - Protein Structure 1977
Fatty acid binding to cytoplasmic proteins of myocardium and red and white skeletal muscle in the rat. A possible new role for myoglobin
J Gloster, P Harris
Biochemical and Biophysical Research Communications 1977
Cellular localization of ligandin in rat, hamster and man
GM Fleischner, JB Robbins, IM Arias
Biochemical and Biophysical Research Communications 1977
The glutathione S-transferases as a possible detoxification system of rat intestinal epithelium
LM Pinkus, JN Ketley, WB Jakoby
Biochemical Pharmacology 1977
Expression of ligandin and glutathione S-transferase activities by cells in tissue culture
GJ Smith, K Huebner, G Litwack
Biochemical and Biophysical Research Communications 1977
The Non-Covalent Binding of Small Molecules by Ligandin. Interactions with Steroids and Their Conjugates, Fatty Acids, Bromosulphophthalein, Carcinogens, Glutathione and Related Compounds
E TIPPING, B KETTERER, L CHRISTODOULIDES, G ENDERBY
European Journal of Biochemistry 1976
The interactions of haem with ligandin and aminoazo-dye-binding protein A
E Tipping, B Ketterer, L Christodoulides, G Enderby
Biochemical Journal 1976
Spectroscopic studies of the binding of bilirubin by ligandin and aminoazo-dye-binding protein A
E Tipping, B Ketterer, L Christodoulides, G Enderby
Biochemical Journal 1976
Effect of 2,3,7,8‐tetrachlorodibenzo‐<i>p</i>‐dioxin on renal function in the rat
DG Pegg, WR Hewitt, KM McCormack, JB Hook
Journal of Toxicology and Environmental Health 1976
The effect of soluble rat liver proteins on the activity of microsomal stearoyl-CoA and linoleoyl-CoA desaturase
R Jeffcoat, PR Brawn, AT James
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1976
Biliary Excretion of Metals
CD Klaassen
Drug Metabolism Reviews 1976
Plasma and tissue protein binding of drugs in pharmacokinetics
W J Jusko, M Gretch
Drug Metabolism Reviews 1976
Influence of drugs and chemicals upon hepatic enzymes and proteins. II. The effects of various barbiturates on the induction and reduction of hepatic cytoplasmic organic anion-binding proteins
Y Adachi, T Yamamoto
Gastroenterologia Japonica 1976
Liver Diseases in Infancy and Childhood
SR Berenberg
1976
Structural and functional studies of ligandin, a major renal organic anion-binding protein
R Kirsch, G Fleischner, K Kamisaka, IM Arias
Journal of Clinical Investigation 1975
Drug induction and sex differences of renal glutathione S-transferases in the rat
G Clifton, N Kaplowitz, JD Wallin, J Kuhlenkamp
Biochemical Journal 1975
Studies on the relationship of hepatic anion-binding proteins and sulfobromophthalein-glutathione conjugation in normal and phenobarbital-treated rats
H Kawasaki, S Sakaguchi, K Arimura, T Irisa, K Tominaga, C Hirayama, H Ibayashi
Biochimica et Biophysica Acta (BBA) - General Subjects 1975
Biliary Excretion of Xenobiotics
CD Klaassen, GL Plaa
Critical Reviews in Toxicology 1975
Interactions of bilirubin and other ligands with ligandin
K Kamisaka, I Listowsky, Z Gatmaitan, IM Arias
Biochemistry 1975
Binding of nonsubstrate ligands to the glutathione S-transferases
JN Ketley, WH Habig, WB Jakoby
The Journal of biological chemistry 1975
The identity of glutathione S-transferase B with ligandin, a major binding protein of liver
WH Habig, MJ Pabst, G Fleischner, Z Gatmaitan, IM Arias, WB Jakoby
Proceedings of the National Academy of Sciences 1974
Urinary D-glucaric acid excretion and plasma antipyrine kinetics during enzyme induction
M Davis, CJ Simmons, B Dordoni, R Williams
British Journal of Clinical Pharmacology 1974
A simple procedure for the purification of porcine ligandine (Y-protein)
JA Trip, JV Dam, T Tepper, GS Que
FEBS Letters 1974
OVERVIEW OF DRUG-PROTEIN BINDING
JR Gillette
Annals of the New York Academy of Sciences 1973
CIRCULAR DICHROISM STUDIES OF Y PROTEIN (LIGANDIN), A MAJOR ORGANIC ANION BINDING PROTEIN IN LIVER, KIDNEY, AND SMALL INTESTINE
K Kamisaka, I Listowsky, IM Arias
Annals of the New York Academy of Sciences 1973
Relationship between plasma and muscle concentrations of ketone bodies and free fatty acids in fed, starved and alloxan-diabetic states
OE Owen, H Markus, S Sarshik, M Mozzoli
Biochemical Journal 1973
Diagnosis of Gilbert's syndrome: role of reduced caloric intake test
D Owens, S Sherlock
British medical journal 1973
Jaundice
S Sherlock
British medical journal 1962
Methods of Biochemical Analysis: Glick/Methods
D Glick
1960

← Previous 1 2 3 4 5 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts