An Evaluation of Fetal Renal Function in a Chronic Sheep Preparation

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Abstract

Fetal renal function in the sheep was investigated in a chronic preparation which permitted repeated evaluations of urine flow and osmolality as well as renal clearances in animals which were unanesthetized and remote from acute surgical stress. Measurements of fetal blood pressure, pH, osmolality, fetal growth in utero, and final outcome did not indicate an adverse effect of the experimental procedure on the fetus.

Authors

Edwin L. Gresham, John H. G. Rankin, Edgar L. Makowski, Giacomo Meschia, Frederick C. Battaglia