Citations to this article

A decreased metabolic clearance rate of aldosterone in benign essential hypertension
W. Nowaczynski, … , O. Kuchel, J. Genest
W. Nowaczynski, … , O. Kuchel, J. Genest
Published October 1, 1971
Citation Information: J Clin Invest. 1971;50(10):2184-2190. https://doi.org/10.1172/JCI106713.
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Research Article

A decreased metabolic clearance rate of aldosterone in benign essential hypertension

Abstract

Aldosterone secretion rate, metabolic clearance rate, and/or plasma concentration were determined in 16 patients with benign, uncomplicated essential hypertension and compared with those of control subjects. The mean metabolic clearance rate of aldosterone in 10 patients was significantly (P < 0.001) lower (mean 867 liters of plasma/day per m2 ±270 SD) than in a group of 7 healthy subjects (mean 1480 liters/day per m2 ±265 SD). Secretion rates in 13 patients (including the 10 already mentioned) tended to be low (83 ±43 vs. 109 ±54 μg/day) and plasma concentrations tended to be high (13.6 ±4.6 vs. 7.5 ±4.8 ng/100 ml), but neither of these differences was statistically significant.

Authors

W. Nowaczynski, O. Kuchel, J. Genest

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Total citations by year

Year: 2017 2011 1991 1987 1986 1985 1983 1982 1980 1979 1978 1977 1976 1975 1974 1973 1972 Total
Citations: 1 1 1 2 1 1 1 1 2 2 1 3 5 6 4 1 2 35
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Citations to this article (35)

Title and authors Publication Year
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T Akimoto, S Muto, C Ito, H Takahashi, S Takeda, Y Ando, E Kusano 		Clinical and Experimental Hypertension 2011
Normotensive young men with family histories of hypertension gain weight and decrease their intraerythrocyte sodium content during a 5-year follow-up
BR Widgren, H Herlitz, O Jonsson, G Berglund, J Wikstrand, OK Andersson 		Journal of Internal Medicine 1991
Arterial and Venous Systems in Essential Hypertension
ME Safar, GM London, AC Simon, YA Weiss 		1987
Renin Angiotensin Aldosterone Axis, Including Aldosterone Binding Globulin and Blood Pressure in Three Species of Nonhuman Primates
D Mavoungou, W Nowaczynski, RW Cooper, JY Collet, K Fung 		Journal of Medical Primatology 1987
Detection of primary aldosteronism by the 6-hour integrated aldosterone/renin ratio
Z Zadik, PA Levin, BP Hamilton, AA Kowarski 		Hypertension 1986
The Diagnostic Value of the 24 Hour Integrated Concentration of Plasma Aldosterone
Z Zadik, P Levin, A Kowarski 		Clinical and Experimental Hypertension 1985
Aldosterone-binding globulin-induced hypertension in the rat. A new experimental model
M Nowaczynski, W Nowaczynski, D Mavoungou, F Lioy, G Wilkins, K Fung, W Boyko 		Hypertension 1983
ALDOSTERONE IN SUSTAINED ESSENTIAL HYPERTENSION
ME Safar, AC SIMON, SA Dard, HR Parlier, NE Pauleau, ML Vincent, JE Sassard 		Clinical Endocrinology 1982
INCREASED 18-HYDROXYCORTICOSTERONE RESPONSES TO FRUSEMIDE IN ESSENTIAL HYPERTENSION
PF Semple, PA Mason, R Fraser 		Clinical Endocrinology 1980
Abnormal urinary kallikrein in hypertension is not related to aldosterone or plasma renin activity
WJ Lawton, AE Fitz 		Hypertension 1980
Genetic aspects of plasma aldosterone binding globulins in families of patients with essential hypertension, including isolation of novel thermostable homologues from plasma and urine
W Nowaczynski, P Landais, T Murakami, M Nowaczynski, D Mavoungou, B Vitullo 		Journal of Steroid Biochemistry 1979
Hormonal Steroids
W Nowaczynski, P Landais, T Murakami, M Nowaczynski, D Mavoungou, B Vitullo 		Hormonal Steroids 1979
Role of the adrenal cortex and sodium in the pathogenesis of human hypertension
J Genest, W Nowaczynski, R Boucher, O Kuchel 		Canadian Medical Association journal 1978
Effects of acth and posture on aldosterone metabolism in essential hypertension
W Nowaczynski, GP Guthrie, FH Messerli, J Genest, O Kuchel, M Honda, J Grose 		Journal of Steroid Biochemistry 1977
The measurement of urinary tetrahydroaldosterone by radioimmunoassay
JH Pratt, MM Holbrook, SL Dale, JC Melby 		Journal of Steroid Biochemistry 1977
Effects of angiotensin II on steroid metabolism and hepatic blood flow in man
FH Messerli, W Nowaczynski, M Honda, J Genest, R Boucher, O Kuchel, JM Rojo-Ortega 		Circulation research 1977
Proceedings of the Fourth International Congress on Hormonal Steroids
RK Kalkhoff 		Proceedings of the Fourth International Congress on Hormonal Steroids 1976
Proceedings of the 1975 Laurentian Hormone Conference
J Genest, W Nowaczynski, O Kuchel, R Boucher, J Rojo-Ortega, G Constantopoulos, D Ganten, F Messerli 		Proceedings of the 1975 Laurentian Hormone Conference 1976
Plasma deoxycorticosterone and aldosterone in essential hypertension
M Honda, W Nowaczynski, FH Messerli, O Kuchel, J Genest 		Journal of Steroid Biochemistry 1976
Enhanced aldosterone response to angiotensin II in human hypertension
ES Kisch, RG Dluhy, GH Williams 		Circulation research 1976
Mineralocorticoid secretion in essential hypertension with normal and low plasma renin activity
FH Messerli, O Kuchel, W Nowaczynski, K Seth, M Honda, S Kubo, R Boucher, G Tolis, J Genest 		Circulation 1976
Aldosterone and renin in essential hypertension
J Genest, W Nowaczynski, R Boucher, O Kuchel, JM Rojo-Ortega 		Canadian Medical Association journal 1975
Jeremiah Metzger lecture, 1974: The renin-angiotensin system. Some new aspects
J Genest, R Boucher, O Kuchel, JM Rojo-Ortega, W Nowaczynski 		Transactions of the American Clinical and Climatological Association 1975
Mineralocorticoid activity in patients in the early benign phase of essential hypertension
J Genest, W Nowaczynski, O Kuchel, F Messerli, R Boucher, M Rojo-Ortega 		Journal of Steroid Biochemistry 1975
Decreased excretion of ring-A reduced steroid metabolites by hypertensive females
AC Dey, IR Senciall 		Biochemical Medicine 1975
Dynamic aldosterone and 18-hydroxydeoxycorticosterone studies in labile and stable benign essential hypertension
W Nowaczynski, O Küchel, J Genest, FH Messerli, M Honda, G Tolis, K Seth, R Parvin-Pande, S Kubo, J Grose, F Ledoux, M Lebel 		Journal of Steroid Biochemistry 1975
Splanchnic blood flow in essential hypertension and in hypertensive patients with renal artery stenosis
FH Messerli, J Genest, W Nowaczynski, O Kuchel, M Honda, Y Latour, G Dumont 		Circulation 1975
Perspectives on the renin-angiotensin-aldosterone system in hypertension
AH Vagnucci, AP Shapiro 		Metabolism 1974
Radioimmuoassay for aldosterone and normal values under various physiological conditions
W Nowaczynski, C Sasaki, J Genest 		Journal of Steroid Biochemistry 1974
Urinary Kallikrein Excretion in Hypertensive Man: Relationships to Sodium intake and Sodium-Retaining Steroids
HS Margolius, DA Horwitz, JJ Pisano, HR Keiser 		Circulation research 1974
Angiotensin
IH Page, FM Bumpus 		1974
Plasma aldosterone-renin interrelationships in various forms of essential hypertension
FR Bühler, JH Laragh, JE Sealey, HR Brunner 		The American Journal of Cardiology 1973
New evidences of disturbances of mineralocorticoid activity in benign, uncomplicated essential hypertension
J Genest, WJ Nowaczynski, O Küchel, C Sasaki 		Transactions of the American Clinical and Climatological Association 1972
Renin, angiotensin and aldosterone system in pathogenesis and management of hypertensive vascular disease
JH Laragh, L Baer, HR Brunner, FR Buhler, JE Vaughan 		The American Journal of Medicine 1972

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