Citations to this article

The formation and metabolism of 3α,7α-dihydroxy-5β-cholestan-26-oic acid in man
Russell F. Hanson
Russell F. Hanson
Published October 1, 1971
Citation Information: J Clin Invest. 1971;50(10):2051-2055. https://doi.org/10.1172/JCI106698.
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Research Article

The formation and metabolism of 3α,7α-dihydroxy-5β-cholestan-26-oic acid in man

Abstract

The formation and metabolism of a naturally occurring C27 bile acid, 3α,7α-dihydroxy-5β-cholestan-26-oic acid, was studied in patients with T-tube bile fistulas. C-26-cholesterol-14C was shown to be converted to this C27 bile acid. After synthesis and labeling with tritium, 3α,7α-dihydroxy-5β-cholestan-26-oic acid was efficiently metabolized to chenodeoxycholic acid. After oral and i.v. administration there was conversion of about 80% of the administered amount to chenodeoxycholic acid. A small amount, less than 2% of the administered radioactivity, was converted to cholic acid. The remainder of the radioactivity was excreted in two unidentified peaks of radioactivity.

Authors

Russell F. Hanson

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Year: 1996 1994 1992 1986 1985 1984 1983 1980 1979 1977 1976 1975 1974 Total
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Citations to this article (26)

Title and authors Publication Year
Comparison of side chain oxidation of potential C27-bile acid intermediates between mitochondria and peroxisomes of the rat liver: presence of beta-oxidation activity for bile acid biosynthesis in mitochondria
M Une, M Konishi, M Yoshii, T Kuramoto, T Hoshita 		Journal of lipid research 1996
Identification of (24E)-3 alpha,7 alpha-dihydroxy-5 beta-cholest-24-enoic acid and (24R,25S)-3 alpha,7 alpha,24-trihydroxy-5 beta-cholestanoic acid as intermediates in the conversion of 3 alpha,7 alpha-dihydroxy-5 beta-cholestanoic acid to chenodeoxycholic acid in rat liver homogenates
M Une, A Inoue, T Kurosawa, M Tohma, T Hoshita 		Journal of lipid research 1994
Synthesis of 3α,7α-dihydroxy-5β-cholestan-26-oic acid from 3α,7α,12α-trihydroxy-5β-cholestan-26-oic acid: configuration in the bile of Alligator mississippiensis
AK Batta, R Mirchandani, G Salen, S Shefer 		Steroids 1992
In vitro formation of bile acids from di- and trihydroxy-5β-cholestanoic acid in human liver peroxisomes
BF Kase, K Prydz, I Björkhem, JI Pedersen 		Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1986
HepG2. A human hepatoblastoma cell line exhibiting defects in bile acid synthesis and conjugation
GT Everson, MA Polokoff 		The Journal of biological chemistry 1986
In vivo and vitro studies on formation of bile acids in patients with Zellweger syndrome. Evidence that peroxisomes are of importance in the normal biosynthesis of both cholic and chenodeoxycholic acid
BF Kase, JI Pedersen, B Strandvik, I Björkhem 		Journal of Clinical Investigation 1985
Formation and Metabolism of Bile Alcohols in Man
G Karlaganis, J SjÖVall 		Hepatology 1984
Improved synthesis of 5β-cholestane-3α,7α,12α, 26(27)-tetrol isomers from cholic acid
R Somanathan, S Krisans 		Steroids 1984
Role of the 26-hydroxylase in the biosynthesis of bile acids in the normal state and in cerebrotendinous xanthomatosis. An in vivo study
I Björkhem, O Fausa, G Hopen, H Oftebro, JI Pedersen, S Skrede 		Journal of Clinical Investigation 1983
New Comprehensive Biochemistry
S Yamamoto 		New Comprehensive Biochemistry 1983
Evidence for a lack of regulatory importance of the 12 alpha-hydroxylase in formation of bile acids in man: an in vivo study
I Björkhem, M Eriksson, K Einarsson 		Journal of lipid research 1983
Competitive inhibition of side chain oxidation of 3 alpha, 7 alpha-dihydroxy-5 beta-cholestan-26-oic acid by 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestan-26-oic acid in the hamster
OW Cass, GC Williams, RF Hanson 		Journal of lipid research 1980
An in vivo evaluation of the quantitative significance of several potential pathways to cholic and chenodeoxycholic acids from cholesterol in man
L Swell, J Gustafsson, CC Schwartz, LG Halloran, H Danielsson, ZR Vlahcevic 		Journal of lipid research 1980
Biosynthesis of bile acids in man. Multiple pathways to cholic acid and chenodeoxycholic acid
ZR Vlahcevic, CC Schwartz, J Gustafsson, LG Halloran, H Danielsson, L Swell 		The Journal of biological chemistry 1980
Metabolism of 3 alpha, 7 alpha-dihydroxy-5 beta-cholestanoic acid by rat liver in vivo and in vitro
J Gustafsson 		Journal of lipid research 1979
Synthesis and Enterohepatic Circulation of Bile Salts
RF Hanson, JM Pries 		Gastroenterology 1977
Evidence for carrier proteins in bile acid synthesis The effect of squalene and sterol carrier protein and albumin on the activity of 12α-hydroxylase
GA Grabowski, KE McCoy, GC Williams, ME Dempsey, RF Hanson 		Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1976
The Hepatobiliary System
W Taylor 		1976
Quantitative aspects of the conversion of 5 beta-cholestane intermediates to bile acids in man
CC Schwartz, BI Cohen, ZR Vlahcevic, DH Gregory, LG Halloran, T Kuramoto, EH Mosbach, L Swell 		The Journal of biological chemistry 1976
Side chain hydroxylation of cholesterol, campesterol and β-sitosterol in rat liver mitochondria
L Aringer, P Eneroth, L Nordström 		Journal of lipid research 1976
The metabolism of 3α, 7α, 12α-trihydroxy-5β-cholestan-26-oic acid into cholic: an enzyme assay using homogenates of human liver
RF Hanson, HL Sharp, GC Williams 		Journal of lipid research 1976
Biosynthesis of bile acids in man. Hydroxylation of the C27-steroid side chain
I Björkhem, J Gustafsson, G Johansson, B Persson 		Journal of Clinical Investigation 1975
The metabolism of 3alpha, 7alpha, 12alpha-trihydorxy-5beta-cholestan-26-oic acid in two siblings with cholestasis due to intrahepatic bile duct anomalies. An apparent inborn error of cholic acid synthesis
RF Hanson, JN Isenberg, GC Williams, D Hachey, P Szczepanik, PD Klein, HL Sharp 		Journal of Clinical Investigation 1975
New bile alcohols — synthesis of 5β-cholestane-3α, 7α, 25-triol and 5β-cholestane-3α, 7α, 25-24(14C)-triol1
BI Cohen, GS Tint, T Kuramoto, EH Mosbach 		Steroids 1975
Bile acids
MM Mui, WH Elliott 		Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1975
Effects of Long Term Feeding of Chenodeoxycholic Acid on Biosynthesis and Metabolism of Bile Acids in the Rat
H Danielsson, G Johansson 		Gastroenterology 1974

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