Citations to this article

Amino acid oxidase of leukocytes in relation to H2O2-mediated bacterial killing
Marlene R. Eckstein, … , Robert L. Baehner, David G. Nathan
Marlene R. Eckstein, … , Robert L. Baehner, David G. Nathan
Published September 1, 1971
Citation Information: J Clin Invest. 1971;50(9):1985-1991. https://doi.org/10.1172/JCI106690.
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Research Article

Amino acid oxidase of leukocytes in relation to H2O2-mediated bacterial killing

Abstract

D-Amino acid oxidase and L-amino acid oxidase have been measured in sucrose homogenates of polymorphonuclear leukocytes (PMN) obtained from guinea pigs and humans. Subcellular distribution patterns and studies on latency indicate that these oxidases are soluble enzymes. Their hydrogen peroxide-generating capacity was verified. Chronic granulomatous disease PMN, which lack a respiratory burst and fail to generate H2O2 during phagocytosis and do not kill catalase positive bacteria, had peroxide-generating amino acid oxidase activity equal to that found in PMN homogenates from patients with bacterial infections. The precise metabolic and bactericidal role of amino acid oxidases in PMN remains uncertain.

Authors

Marlene R. Eckstein, Robert L. Baehner, David G. Nathan

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Citations to this article (24)

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