Citations to this article
Citation Information: J Clin Invest. 1971;50(9):1910-1916. https://doi.org/10.1172/JCI106683.
Abstract
Intestinal absorption of the monoglutamate form of the principal dietary and circulating folate compound, 5-methyltetrahydrofolic acid (5-MTHF), was studied in the rat utilizing a synthetic highly purified radiolabeled diastereoisomer. Chromatography confirmed that the compound was not altered after transfer from the mucosa to the serosa. Accumulation against a concentration gradient was not observed in duodenal, jejunal, or ileal segments at 5-MTHF concentration from 0.5 to 500 nmoles/liter. Unidirectional transmural flux determination also did not indicate a significant net flux. Mucosal to serosal transfer of 5-MTHF was similar in all segments of the intestine and increased in a linear fashion with increased initial mucosal concentrations. Further, no alteration in 5-MTHF transfer was found when studied in the presence of metabolic inhibitors or folate compounds.
Authors
Williamson Strum, Peter F. Nixon, Joseph B. Bertino, Henry J. Binder
Total citations by year
Citations to this article (20)
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GF Ball |
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Zeitschrift für Ernährungswissenschaft | 1991 |
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Gastrointestinal absorption of folates and antifolates
J Selhub, GJ Dhar, IH Rosenberg |
Pharmacology & Therapeutics | 1983 |
|
Effect of caffeine, theophylline and nicotine on d-glucose and folate transport in rat jejunal brush border membrane vesicles
KY Ling, RG Faust |
International Journal of Biochemistry | 1982 |
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TK Basu |
International Journal of Environmental Studies | 1981 |
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Kinetics of the Normal Folate Enterohepatic Cycle
SE Steinberg, CL Campbell, RS Hillman |
Journal of Clinical Investigation | 1979 |
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Enzymatic reduction and methylation of folate following pH-dependent, carrier-mediated transport in rat jejunum
WB Strum |
Biochimica et Biophysica Acta (BBA) - Biomembranes | 1979 |
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An ATPase dependent, radiosensitive acidic microclimate essential for intestinal folate absorption
V Kesavan, JM Noronha |
The Journal of Physiology | 1978 |
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Transport of 5-methyltetrahydrofolic acid and folic acid in freshly isolated hepatocytes
DW Horne, WT Briggs, C Wagner |
The Journal of biological chemistry | 1978 |
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Isotopes in Megaloblastic Anaemia
I Chanarin |
Clinics in Haematology | 1977 |
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Absorption and Malabsorption of Folates
IH Rosenberg |
Clinics in Haematology | 1976 |
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Uptake of 5-methyltetrahydrofolic acid by the rat jejunum
JA Blair, AJ Matty, A Razzaque |
The Journal of Physiology | 1975 |
|
Folate transport in the choroid plexus
CP Chen, C Wagner |
Life Sciences | 1975 |
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The pathogenesis of folic acid deficiency in man
DG Weir |
Irish Journal of Medical Science | 1974 |
|
Absorption of folic acid by everted segments of rat jejunum
JA Blair, IT Johnson, AJ Matty |
The Journal of Physiology | 1974 |
|
Acid Microclimate in Intestinal Absorption
J Blair, A Matty |
1974 | |
|
Intestinal Folate Absorption II. CONVERSION AND RETENTION OF PTEROYLMONOGLUTAMATE BY JEJUNUM
EJ Olinger, JR Bertino, HJ Binder |
Journal of Clinical Investigation | 1973 |
|
Uptake and Reduction of Radioactive Folate by Everted Sacs of Rat Small Intestine
J Selhub, H Brin, N Grossowicz |
European Journal of Biochemistry | 1973 |
|
Drugs and Folic Acid Absorption
IH Rosenberg |
Gastroenterology | 1972 |
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