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Citations to this article

Effect of Free Fatty Acids on Myocardial Function and Oxygen Consumption in Intact Dogs
Ole D. Mjøs
Ole D. Mjøs
Published July 1, 1971
Citation Information: J Clin Invest. 1971;50(7):1386-1389. https://doi.org/10.1172/JCI106621.
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Research Article

Effect of Free Fatty Acids on Myocardial Function and Oxygen Consumption in Intact Dogs

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Abstract

Myocardial function and oxygen consumption (MV̇O2) were studied during increased myocardial uptake of free fatty acids (FFA) induced by intravenous infusion of a fat emulsion (Intralipid) after heparinization in anesthetized and intact dogs. During raised myocardial uptake of FFA, MV̇O2 increased in all experiments. On the average, MV̇O2 rose from 8.6 to 10.7 ml/min·100 g, or 26% (P < 0.001). This was mainly due to elevated myocardial oxygen extraction, as myocardial blood flow was unchanged, or increased slightly. In the recovery period, MV̇O2 returned to normal. Left ventricular pressure, the maximal rate of rise of left ventricular pressure (dP/dt), heart rate, and cardiac output remained unchanged during the raised myocardial uptake of FFA.

Authors

Ole D. Mjøs

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Low thrombogenicity of polyethylene glycol–grafted cellulose membranes does not influence heparin requirements in hemodialysis
MJ Wright, G Woodrow, S Umpleby, S Hull, AM Brownjohn, JH Turney
American Journal of Kidney Diseases 1999
Beta-receptor blockade decreases carnitine palmitoyl transferase I activity in dogs with heart failure
AR Panchal, WC Stanley, J Kerner, HN Sabbah
Journal of Cardiac Failure 1998
Advances in Organ Biology
AJ Liedtke
Advances in Organ Biology 1998
Comparative hemodynamic effects of three different parenterally administered lipid emulsions in conscious dogs:
MV de Velde, PF Wouters, N Rolf, HV Aken, E Vandermeersch
Critical Care Medicine 1998
Enhanced Preservation of Acutely Ischemic Myocardium and Improved Clinical Outcomes Using Glucose-Insulin-Potassium (GIK) Solutions
HL MD
The American Journal of Cardiology 1997
Dichloroacetate as metabolic therapy for myocardial ischemia and failure
RM Bersin, PW Stacpoole
American Heart Journal 1997
Substrate selection early after reperfusion of ischemic regions in the working rabbit heart
MA Solomon, FM Jeffrey, CJ Storey, AD Sherry, CR Malloy
Magnetic Resonance in Medicine 1996
Effects of Isoproterenol Infusion on the Myocardial Uptake of Fatty Acids and Other Substrates in Lambs with an Aortopulmonary Shunt
JW Gratama, JJ Meuzelaar, M Dalinghaus, WG Zijlstra, JR Kuipers
Pediatric Research 1996
Insulin infusion in diabetic patients with acute myocardial infarction
G Davey, P Mckeigue
BMJ (Clinical research ed.) 1996
Advances in Lipobiology
PJ Trotter, DR Voelker
Advances in Lipobiology 1996
Limiting ischemic myocardial damage using glucose-insulin-potassium solutions
HL Lazar, X Zhang, S Rivers, S Bernard, RJ Shemin
The Annals of Thoracic Surgery 1995
Myocardial protection for coronary bypass grafting: The Toronto Hospital perspective
JS Ikonomidis, V Rao, RD Weisel, N Hayashida, T Shirai
The Annals of Thoracic Surgery 1995
Intravenous lipid infusion results in myocardial lipid droplet accumulation combined with reduced myocardial performance in heparinized rabbits
S Hexeberg, I Hessevik, E Hexeberg
Acta Physiologica Scandinavica 1995
Substrate selection in the isolated working rat heart: effects of reperfusion, afterload, and concentration
FM Jeffrey, V Diczku, AD Sherry, CR Malloy
Basic Research in Cardiology 1995
Effects of glucose and fatty acids on myocardial ischaemia and arrhythmias
EM Oliver, LH Opie
The Lancet 1994
Plasma fatty acid levels in infants and adults after myocardial ischemia
GD Lopaschuk, R Collins-Nakai, PM Olley, TJ Montague, G McNeil, M Gayle, P Penkoske, BA Finegan
American Heart Journal 1994
Regulation of fatty acid oxidation in the mammalian heart in health and disease
GD Lopaschuk, DD Belke, J Gamble, I Toshiyuki, BO Schönekess
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1994
Cardiac efficiency
J D Schipke
Basic Research in Cardiology 1994
Substrate preference of isolated perfused rat hearts during hypothermia and rewarming
TK Steigen, T Tveita, C Korvald, T Solberg, E Bjordal, K Ytrehus, TS Larsen
Acta Physiologica Scandinavica 1993
Beneficial effect of carnitine on mechanical recovery of rat hearts reperfused after a transient period of global ischemia is accompanied by a stimulation of glucose oxidation
TL Broderick, HA Quinney, CC Barker, GD Lopaschuk
Circulation 1993
Role of fatty acid metabolites in the development of myocardial ischemic damage
JF Hütter, S Soboll
International Journal of Biochemistry 1992
Lipolytic effect of low-molecular-weight-heparin (Fragmin®) and heparin/dihydroergotamine in thromboprophylactic doses during total hip replacement
T Myrmel, TS Larsen, O Reikerås
Scandinavian Journal of Clinical & Laboratory Investigation 1992
Alterations in left ventricular mechanics, energetics, and contractile reserve in experimental heart failure
MR Wolff, PP de Tombe, Y Harasawa, D Burkhoff, S Bier, WC Hunter, G Gerstenblith, DA Kass
Circulation research 1992
The relative contribution of glucose and fatty acids to ATP production in hearts reperfused following ischemia
GD Lopaschuk, M Saddik
Molecular and Cellular Biochemistry 1992
Lipid Metabolism in the Healthy and Disease Heart
GJ van der Vusse, H Stam
1992
Myocardial Response to Acute Injury
JR Parratt
1992
Strenuous prolonged exercise elevates resting metabolic rate and causes reduced mechanical efficiency
R Bahr, PK Opstad, JI Medbø, OM Sejersted
Acta Physiologica Scandinavica 1991
Metabolic Support in Severe Cardiopulmonary Insufficiency
B Skeie, O Kirvelä, T Manner, V Kvetan, J Askanazi
Anesthesiology Clinics of North America 1991
Elevated levels of nonesterified fatty acids in the myocardium of alloxan diabetic rats
J Chattopadhyay, EW Thompson, HH Schmid
Lipids 1990
Effects of antianginal drugs on myocardial energy metabolism in coronary artery disease
JP Bagger
Pharmacology & Toxicology 1990
Muscle relaxants change myocardial metabolism in patients with ischemic heart disease during high-dose fentanyl anesthesia
M Gilbert, EA Anderson, A Bróndbo, LJ Bjertnaes
Acta Anaesthesiologica Scandinavica 1990
Regulation of the oxidative phosphorylation rate in the intact cell
AH From, SD Zimmer, SP Michurski, P Mohanakrishnan, VK Ulstad, WJ Thoma, K Ugurbil
Biochemistry 1990
Glucose and palmitate oxidation in isolated working rat hearts reperfused after a period of transient global ischemia
GD Lopaschuk, MA Spafford, NJ Davies, SR Wall
Circulation research 1990
31P NMR measurement of mitochondrial uncoupling in isolated rat hearts
PB Kingsley-Hickman, EY Sako, K Uğurbil, AH From, JE Foker
The Journal of biological chemistry 1990
Enhanced myocardial preservation by nicotinic acid, an antilipolytic compound: Mechanism of action
S Datta, DK Das, RM Engelman, H Otani, JA Rousou, RH Breyer, J Klar
Basic Research in Cardiology 1989
Inosine causing insulin release and increased myocardial uptake of carbohydrates relative to free fatty acids in dogs
OA Smiseth, P Gunnes, T Sand, OD Mjøs
Clinical Physiology 1989
Nonthrombolytic intervention in acute myocardial infarction
JM Kirshenbaum
The American Journal of Cardiology 1989
Myocardial metabolic and hemodynamic effects of dichloroacetate in coronary artery disease
TJ Wargovich, RG MacDonald, JA Hill, RL Feldman, PW Stacpoole, CJ Pepine
The American Journal of Cardiology 1988
Lipid effects of smoking
OD Mjøs
American Heart Journal 1988
Changes in substrate metabolism and effects of excess fatty acids in reperfused myocardium
AJ Liedtke, L DeMaison, AM Eggleston, LM Cohen, SH Nellis
Circulation research 1988
Clinical Aspects of Cardiac Arrhythmias
AJ Camm, DE Ward
1988
Lipid metabolism in the normoxic and ischaemic heart
H Stam, GJ van der Vusse
1987
Changes in myocardial substrate and energy metabolism by S-(4)-hydroxyphenylglycine and an N-(6)-derivative of adenosine
H Kahles, W Schäfer, T Lick, J Junggeburth, K Kochsiek
Basic Research in Cardiology 1986
Temperature-Specific Effects of Adjuvant Diltiazem Therapy on Myocardial Energetics Following Potassium Cardioplegic Arrest
IB Krukenkamp, NA Silverman, D Sorlie, A Pridjian, S Levitsky
The Annals of Thoracic Surgery 1986
Radioiodinated fatty acids for cardiological diagnosis
HJ Machulla, EJ Knust, K Vyska
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes 1986
Transperitoneal Absorption of Intralipid in Rats: Total Serum Fatty Acids and Triglyceride after Absorption
J Moran, G Cruz, F Nogue-Rales, F Requena, L Vinagre, L Garcia-Sancho
JPEN. Journal of parenteral and enteral nutrition 1986
Pediatric Cardiology
EF Doyle, MA Engle, WM Gersony, WJ Rashkind, NS Talner
Pediatric Cardiology 1986
Metabolic effects of low and high doses of insulin during beta-receptor blockade in dogs
O Reikerås, P Gunnes, D Sørlie, R Ekroth
Clinical Physiology 1985
Haemodynamic and metabolic consequences of elevated plasma free fatty acids during acute ischaemic left ventricular failure in dogs
OA Smiseth, OD Mjøs
Scandinavian Journal of Clinical & Laboratory Investigation 1985
Clinical Pharmacology of Antianginal Drugs
U Abshagen
1985
Beta blockade during and after myocardial infarction: An overview of the randomized trials
S Yusuf, R Peto, J Lewis, R Collins, P Sleight
Progress in Cardiovascular Diseases 1985
Effects of Timolol on Platelets in Coronary Sinus Blood and on Myocardial Ischemia during Pacing-induced Angina
E Thaulow, J Dale
Acta Medica Scandinavica 1984
Comparative effects of propranolol, timolol and metoprolol on myocardial infarct size after experimental coronary artery occlusion
H Vik-Mo, PR Maroko, LG Ribeiro
Journal of the American College of Cardiology 1984
Effects of a selective thromboxane synthetase inhibitor, dazoxiben, and of acetylsalicylic acid on myocardial ischemia in patients with coronary artery disease
E Thaulow, J Dale, E Myhre
The American Journal of Cardiology 1984
Amphipathic metabolites and membrane dysfunction in ischemic myocardium
PB Corr, RW Gross, BE Sobel
Circulation research 1984
Myocardial Ischemia and Lipid Metabolism
R Ferrari, AM Katz, A Shug, O Visioli
1984
Changes in myocardial substrate utilisation and protection of ischemic stressed myocardium by oxfenicine [(S)-4-hydroxyphenylglycine]
H Korb, A Hoeft, DH Hunneman, R Schraeder, HG Wolpers, W Wober, G Hellige
Naunyn-Schmiedeberg's Archives of Pharmacology 1984
The effect of palmitate and lactate on mechanical performance and metabolism of cat and rat myocardium
AJ Drake-Holland, G Elzinga, MI Noble, HE Keurs, FN Wempe
The Journal of Physiology 1983
Induction of a reversible cardiac lipidosis by a dietary long-chain fatty acid (erucic acid). Relationship to lipid accumulation in border zones of myocardial infarcts
KR Chien, A Bellary, M Nicar, A Mukherjee, LM Buja
The American Journal of Pathology 1983
Atherosclerosis VI
FG Schettler, AM Gotto, G Middelhoff, AJ Habenicht, KR Jurutka
1983
Cardiovascular actions of the calmodulin inhibitor felodipine
PD Verdouw, BH Wolffenbuttel, MG Scheffer
Naunyn-Schmiedeberg's Archives of Pharmacology 1983
Herzrhythmusstörungen
G Breithardt, B Brisse, E Jähnchen, W Kasper, HJ Knieriem, ER von Leitner, B Lüderitz, P Matthiesen, D Mecking, T Meinertz, CN dAlnoncourt, H Nawrath, H Neuss, J Ostermeyer, M Schlepper, L Seipel, G Steinbeck, K Theisen, J Thormann, D Trenk, HA Tritthart
1983
Substrate utilization in the myocardium
AJ Drake
Basic Research in Cardiology 1982
Intracoronary infusion of small doses of nifedipine lowers regional myocardial O2-consumption without altering regional myocardial function
PD Verdouw, FJ Cate, JM Hartog, MG Scheffer, H Stam
Basic Research in Cardiology 1982
Effect of hyaluronidase on substrate exchange and blood flow in the ischaemic myocardium of the dog
OA Smiseth, H Refsum, H Vik-Mo, OD Mjøs
Clinical Physiology 1982
Influence of Myocardial Substrate Utilization on the Oxygen Consumption of the Heart
H Kahles, G Hellige, DH Hunneman, VA Mezger, HJ Bretschneider
Clinical Cardiology 1982
The effect of elevated arterial free fatty acid concentrations on hemodynamics and myocardial metabolism and blood flow during ischemia
FW Prinzen, GJ Vusse, WA Coumans, R Kruger, CW Verlaan, RS Reneman
Basic Research in Cardiology 1981
Unfavorable effects of ventricular pacing on myocardial energetics
D Baller, HG Wolpers, J Zipfel, A Hoeft, G Hellige
Basic Research in Cardiology 1981
Effects of cardioselective and non-cardioselective beta-blockade on adrenaline-induced metabolic and cardiovascular responses in man
S Raptis, J Rosenthal, D Welzel, S Moulopoulos
European Journal of Clinical Pharmacology 1981
Free fatty acids and the electrophysiology of the dog heart in situ: effects of isoprenaline, nicotinic acid and lipid emulsion with heparin
ES Platou, ES Myhre, H Refsum, OD Mjøs
Clinical Physiology 1981
Effect of fatty acids on the ventricular arrhythmia threshold in the isolated heart of the rabbit
MF Murnaghan
British Journal of Pharmacology 1981
Influence of free fatty acids on myocardial oxygen consumption and ischemic injury
H Vik-Mo, OD Mjøs
The American Journal of Cardiology 1981
EFFECT OF FATTY ACIDS ON THE VENTRICULAR ARRHYTHMIA THRESHOLD IN THE ISOLATED HEART OF THE RABBIT
MF Murnaghan
British Journal of Pharmacology 1981
Cardiovascular Physiology: Heart, Peripheral Circulation and Methodology
H Vik-Mo, OD Mjøs, RA Riemersma, MF Oliver
Cardiovascular Physiology: Heart, Peripheral Circulation and Methodology 1981
Norepinephrine-stimulated lipolysis in acute and chronic hypoxemia
D Baum, P Oyer
American journal of physiology. Endocrinology and metabolism 1981
Hormonal and metabolic reactions evoked by acute myocardial infarction
L Ceremuzyński
Circulation research 1981
Lipid-membrane interactions and the pathogenesis of ischemic damage in the myocardium
AM Katz, FC Messineo
Circulation research 1981
Beta-Rezeptorenblocker
HD Bolte, A Schrey
1981
Accumulation of myocardial lipid droplets in dexamethasone-treated mice
RK Lie, HG Jodalen, S Rotevatn
Cell and Tissue Research 1981
Blood viscosity and the overnight fast
HB Aronson, T Horne, SH Blondheim, JT Davidson
Canadian Anaesthetists’ Society Journal 1980
Antiarrhythmic Drugs
HW Moses, PN Yu
The Journal of Clinical Pharmacology 1980
Adrenergic responsiveness after abrupt propranolol withdrawal in normal subjects and in patients with angina pectoris
J Lindenfeld, MH Crawford, RA O'Rourke, SP Levine, MM Montiel, LD Horwitz
Circulation 1980
Propranolol during the evolution and subsequent ten days of myocardial infarction in man: Hemodynamic, initial cardiac energetic, and neurohumoral responses
IS Mueller, PS Rao, J Fletcher, R Evans, F Hertelendy, L Stickley, K Walter
Clinical Cardiology 1979
Beneficial effect of practolol in preventing adrenaline-induced systemic and myocardial metabolic changes
K Herbaczyńsla-Cedro, L Ceremuźyński, B Broniszewska-Ardelt, B Woźniewicz
European Journal of Clinical Investigation 1979
Influence of High Plasma Concentrations of Free Fatty Acids on Heart Rhythm in Healthy Fasting Men
H Wang, K Rasmussen, H Vik-Mo, OD Mjøs, H Grendahl
Acta Medica Scandinavica 1979
Effect of myocardial ischaemia and antilipolytic agents on lipolysis and fatty acid metabolism in the in situ dog heart
H Vik-Mo, RA Riemersma, OD MjøS, MF Oliver
Scandinavian Journal of Clinical & Laboratory Investigation 1979
TESTS FOR GASTROŒSOPHAGEAL REFLUX
WM Liebman
The Lancet 1978
F.F.A., INTESTINAL BYPASS, AND ARTERIAL LIPID ACCUMULATION
DJ Jenkins, JG Kral
The Lancet 1978
Effect of antilipolytic therapy on ST segment elevation during myocardial ischaemia in man
DC Russell, MF Oliver
British heart journal 1978
Some histochemical observations on the myocardial metabolism in experimental conditions
JS Tarach
Acta Histochemica 1978
Metabolic responses of the heart in acute myocardial infarction in man
HS Mueller, SM Ayres
The American Journal of Cardiology 1978
The effect of free fatty acids on myocardial oxygen consumption during atrial pacing and catecholamine infusion in man
S Simonsen, JK Kjekshus
Circulation 1978
Effects of excess free fatty acids on mechanical and metabolic function in normal and ischemic myocardium in swine
AJ Liedtke, S Nellis, JR Neely
Circulation research 1978
Effect of sodium salicylate and acetylsalicylic acid on epicardial ST-segment elevation during coronary artery occlusion in dogs
H Vik-Mo, OD Mjoøs
Scandinavian Journal of Clinical & Laboratory Investigation 1977
Free Fatty Acids in Plasma and Platelets Following Low and High-Dose Heparin during Alimentary Hyperlipaemia
A Nordøy, H Vik-Mo, OD Mjøs, R Johnsen
Acta Medica Scandinavica 1977
Effect of heparin-induced free fatty acid elevation on myocardial oxygen consumption in man
WJ Rogers, HG McDaniel, RE Moraski, CE Rackley, RO Russell
The American Journal of Cardiology 1977
Acute effects of glucose-insulin-potassium infusion on myocardial substrates, coronary blood flow and oxygen consumption in man
WJ Rogers, RO Russell, HG McDaniel, CE Rackley
The American Journal of Cardiology 1977
Distribution of coronary blood flow during acute coronary occlusion in dogs. Effect of nicotinic acid and sodium salicylate
H Vik-Mo
Scandinavian Journal of Clinical & Laboratory Investigation 1977
The role of propranolol in the treatment of acute myocardial infarction
HS Mueller, SM Ayres
Progress in Cardiovascular Diseases 1977
Effect of increased free fatty acids on myocardial oxygen extraction and angina threshold during atrial pacing
GR Dagenais, B Jalbert
Circulation 1977
EFFECT OF REDUCTION OF MYOCARDIAL FREE FATTY ACID METABOLISM RELATIVE TO THAT OF GLUCOSE ON THE ISCHEMIC INJURY DURING EXPERIMENTAL CORONARY ARTERY OCCLUSION IN DOGS
OD Mjøs
Acta Medica Scandinavica 1976
Reduction of hospital mortality rate of acute myocardial infarction with glucose-insulin-potassium infusion
WJ Rogers, AW Stanley, JB Breinig, JW Prather, HG McDaniel, RE Moraski, JA Mantle, RO Russell, CE Rackley
American Heart Journal 1976
Effects of p-chlorophenoxyisobutyrate on myocardial free fatty acid extraction, ventricular blood flow, and epicardial ST-segment elevation during coronary occlusion in dogs
OD Mjos, NE Miller, RA Riemersma, MF Oliver
Circulation 1976
Effects of free fatty acids on electrophysiological properties of ventricular myocardium
B Lderitz, CN d'Alnoncourt, G Steinbeck
Klinische Wochenschrift 1976
Metabolism of free fatty acids, glucose and catecholamines in acute myocardial infarction
LH Opie
The American Journal of Cardiology 1975
Effects of glucose-insulin-potassium on myocardial substrate availability and utilization in stable coronary artery disease
AW Stanley, RE Moraski, RO Russell, WJ Rogers, JA Mantle, RA Kreisberg, HG McDaniel, CE Rackley
The American Journal of Cardiology 1975
Myocardial energy metabolism in patients with ischemic heart disease
W Kübler
Basic Research in Cardiology 1974
Effects of Halothane and Methoxyflurane Anesthesia on Lipid and Carbohydrate Metabolism in Man
A Mäkeläinen
Acta Anaesthesiologica Scandinavica 1974
F.F.A., LIPOLYSIS, AND MYOCARDIAL INFARCTION
MF Oliver, OD Mjs, MJ Rowe
The Lancet 1974
Effect of Dopamine and Calcium on Lipolysis and Myocardial Ischemic Injury following Acute Coronary Occlusion in the Dog
J Lekven, G Semb
Circulation research 1974
‘Stress’ Hormones and Lipid Metabolism
AH Kissebah
Proceedings of the Royal Society of Medicine 1974
Kohlehydrat- und Palmitinsäurestoffwechsel am Myokard der Ratte bei Hypoxie
R Gmeiner, CS Apstein, N Brachfeld
Basic Research in Cardiology 1973
Effects of Glucagon and Isoproterenol on Severity of Acute Myocardial Ischemic Injury
J Lekven, JK Kjekshus, OD Mjös
Scandinavian Journal of Clinical & Laboratory Investigation 1973
Effects of Nicotine on Myocardial Metabolism and Performance in Dogs
OD Mjös, A Ilebekk
Scandinavian Journal of Clinical & Laboratory Investigation 1973
FATTY ACID AS A DETERMINANT OF MYOCARDIAL SUBSTRATE AND OXYGEN METABOLISM IN MAN AT REST AND DURING PROLONGED EXERCISE
ML Wahlqvist, L Kaijser, BW Lassers, LA Carlson
Acta Medica Scandinavica 1973
LIPID METABOLISM OF THE HEART AND ARTERIES IN RELATION TO ISCHÆMIC HEART-DISEASE
LH Opie
The Lancet 1973
Effect of free fatty acids on myocardial function and metabolism in the ischemic dog heart
JK Kjekshus, OD Mjos
Journal of Clinical Investigation 1972
Effect of inhibition of lipolysis on myocardial oxygen consumption in the presence of isoproterenol
OD Mjos
Journal of Clinical Investigation 1971
Free Fatty Acids and Oxygen Consumption in Dogs
OD Mjös
Scandinavian Journal of Clinical & Laboratory Investigation 1971
Effect of Isoproterenol, Glucagon and Calcium on Myocardial Oxygen Consumption in Intact Dogs. A Comparative Study
OD Mjös
Scandinavian Journal of Clinical & Laboratory Investigation 1971
Increased Local Metabolic Rate by Free Fatty Acids in the Intact Dog Heart
OD Mjos, J Kjekshus
Scandinavian Journal of Clinical & Laboratory Investigation 1971
Impact of Admission Glucose on Non-Diabetic Patients with ST-Segment Elevation Myocardial Infarction Treated with Percutaneous Coronary Intervention: A Meta-Analysis
Zhen-Xuan Hao, Yang Liu, Dan-Li Wang, Wen-Jie Han, Lei Wu, Heng-Liang Liu
ACTA CARDIOL SIN
Handbook of Experimental Pharmacology
W Dinh, B Albrecht-Küpper, M Gheorghiade, AA Voors, M der Laan, HN Sabbah
Handbook of experimental pharmacology 2016
Beta-blockers in patients with septic shock: plenty of promise, but no hard evidence yet
WY Kim, SB Hong
Journal of Thoracic Disease 2016
Enhanced Preservation of Acutely lschemic Myocardium Using Glucose-Insulin-Potassium Solutions
HL Lazar
Journal of Cardiac Surgery 1994

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