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Citations to this article

Relative effects of pregnancy, estradiol, and progesterone on plasma insulin and pancreatic islet insulin secretion
N. V. Costrini, R. K. Kalkhoff
N. V. Costrini, R. K. Kalkhoff
Published May 1, 1971
Citation Information: J Clin Invest. 1971;50(5):992-999. https://doi.org/10.1172/JCI106593.
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Research Article

Relative effects of pregnancy, estradiol, and progesterone on plasma insulin and pancreatic islet insulin secretion

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Abstract

Influences of estrogen and progesterone on the development of hyperinsulinemia and augmented pancreatic islet insulin secretion during pregnancy were assessed in this study. Groups of female rats were injected subcutaneously for 21 days with varying daily dosages of estradiol benzoate or progesterone in oil. On day 21, pancreatic islets were isolated by a collagenase method. Total insulin secretion was measured after 90-min incubations of 10 islets in buffered medium containing glucose. Higher physiologic dosages of estradiol or progesterone, singly or in combination, significantly increased islet secretion above values of untreated control rats and were comparable to augmented islet responses of term, 3-wk pregnant rats. Diameter and protein content of islets obtained from steroid-treated and pregnant rats exceeded control measurements in these instances. However, 2-hr preincubations of control islets with 1 or 10 μg/ml of either steroid did not influence subsequent glucose-stimulated insulin output.

Authors

N. V. Costrini, R. K. Kalkhoff

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American journal of physiology. Endocrinology and metabolism 1980
The insulin response to glucose infusion in normal human pregnancy
PM Fisher, HW Sutherland, PD Bewsher
Diabetologia 1980
The insulin response to glucose infusion in gestational diabetes
PM Fisher, HW Sutherland, PD Bewsher
Diabetologia 1980
Role of ovarian hormones in the long-term control of glucose homeostasis: Effects on insulin secretion
CJ Bailey, H Ahmed-Sorour
Diabetologia 1980
In vivo insulin resistance during pregnancy in the rat
A Leturque, P Ferr, P Satabin, A Kervran, J Girard
Diabetologia 1980
The Adenylate cyclase-cyclic AMP system in islets of langerhans and its role in the control of insulin release
GW Sharp
Diabetologia 1979
The effects of pregnancy and lactation on the activities of trypsin and α-chymotrypsin in the rat pancreas
BA Rolls, MJ Henschel, MF Palmer
British Journal of Nutrition 1979
Gonadal effects on food intake and adiposity: A metabolic hypothesis
GN Wade, JM Gray
Physiology & Behavior 1979
The effects of estradiol on body weight and food intake in normal weight VMH-lesioned rats
ME Thompson, VC Cox
Physiology & Behavior 1979
Estradiol and insulin: Independent effects on eating and body weight in rats
SD Dudley, RT Gentry, BS Silverman, GN Wade
Physiology & Behavior 1979
Further characterization of fat diet-induced changes in responsiveness to estrogen and glucose
JK Young, DM Nance, RA Gorski, JH Gordon
Brain Research Bulletin 1979
8 Pancreas
JM Olefsky, OG Kolterman
Clinics in Endocrinology and Metabolism 1979
Estrogen receptor in rat pancreatic islets
M Tesone, GD Chazenbalk, G Ballejos, EH Charreau
Journal of Steroid Biochemistry 1979
Body weight regulation over the estrous cycle of the rat: Basal insulin levels and effect of vagotomy
LH Storlien, GM Martin, WP Bellingham
Behavioral and Neural Biology 1979
Carbohydrate Metabolism in Pregnancy and the Newborn 1978
HW Sutherland, JM Stowers
1979
Effects of pregnancy on the glucose-induced insulin release from cultivated pancreatic islets of the rat
B Ziegler, M Ziegler, H Fiedler
Experientia 1978
Binding of3H-progesterone by isolated rat islets of Langerhans
IC Green, SL Howell, S Seifi, D Perrin
Diabetologia 1978
The Diabetic Pancreas
GF Cahill
New England Journal of Medicine 1978
Plasma insulin response in pregnant and non-pregnant rats: Effects of different dietary carbohydrates
AR Bourne, BC Whaler, J Yudkin
Diabetologia 1978
Principles and Prenatal Growth
F Falkner, JM Tanner
1978
Binding of3H-progesterone by isolated rat islets of Langerhans
IC Green, SL Howell, SE Seifi, D Perrin
Diabetologia 1978
Serum insulin and plasma glucagon in human pregnancy — On the pathogenesis of gestational diabetes. A review
C Kühl
Acta Diabetologica Latina 1977
EFFECT OF PROGESTINS ON GLUCOSE AND LIPID METABOLISM
P Beck
Annals of the New York Academy of Sciences 1977
EFFECT OF HORMONE REPLACEMENT THERAPY ON GLUCOSE TOLERANCE IN POSTMENOPAUSAL WOMEN
M Thom, S Chakravarti, DH Oram, JW Studd
BJOG: An International Journal of Obstetrics and Gynaecology 1977
Alterations in regulation of insulin biosynthesis in pregnancy and starvation studied in isolated rat islets of langerhans
AJ Bone, SL Howell
Biochemical Journal 1977
Fetal fuels. I. Utilization of ketones by isolated tissues at various stages of maturation and maternal nutrition during late gestation
GE Shambaugh, SC Mrozak, N Freinkel
Metabolism 1977
Fetal carbohydrate metabolism: Its clinical importance
SG Gabbe, EJ Quilligan
American Journal of Obstetrics and Gynecology 1977
Body Fuel Metabolism and Diabetes Mellitus in Pregnancy
P Felig
Medical Clinics of North America 1977
Effects of progesterone on some enzymes of fat and carbohydrate metabolism in rat liver
CH Dahm, J Minagawa, M Jellinek
American Journal of Obstetrics and Gynecology 1977
Direct effects of progesterone on rat islets of Langerhans in vivo and in tissue culture
SL Howell, M Tyhurst, IC Green
Diabetologia 1977
Regulation of lipid metabolism in the normal pig aorta Part 1. Influence of insulin and epinephrine on lipid synthesis from [U14C] glucose
JB Somer, CJ Schwartz
Atherosclerosis 1976
Metabolic adaptation to pregnancy shown by increased biosynthesis of insulin in islets of Langerhans isolated from pregnant rats
AJ Bone, KW Taylor
Nature 1976
Proceedings of the Fourth International Congress on Hormonal Steroids
RK Kalkhoff
Proceedings of the Fourth International Congress on Hormonal Steroids 1976
Eukaryotic Cell Function and Growth
JE Dumont, BL Brown, NJ Marshall
1976
Plasma glucagon and insulin in rat pregnancy. Roles in glucose homeostasis
CD Saudek, M Finkowski, RH Knopp
Journal of Clinical Investigation 1975
Sex steroid influence on triglyceride metabolism
HJ Kim, RK Kalkhoff
Journal of Clinical Investigation 1975
The effect of progesterone on plasma insulin in the rabbit
AD Hamburger, AC Kuipers, J Vies
Experientia 1975
Effects of oral contraceptive agents on carbohydrate metabolism
RK Kalkhoff
Journal of Steroid Biochemistry 1975
Diabetes mellitus · A
E Cerasi, P Dieterle, H Ege, A Englhardt, H Frerichs, W Gepts, A Hasselblatt, HR Henrichs, L Herberg, JJ Hoet, H Hungerland, K Jahnke, RJ Jarrett, G Jörgensen, KH Jørgensen, H Kasemir, H Keen, L Kerp, V Leclercq-Meyer, H Liebermeister, G Löffler, R Luft, WJ Malaisse, J Markussen, M Möllering, H Schadewaldt, J Schlichtkrull, K Schöffling, U Schwedes, PC Scriba, F Sundby, KH Usadel, L Weiss, H Zimmermann, K Oberdisse
1975
The effect of progesterone on plasma insulin in the rabbit
AD Hamburger, AC Kuipers, J van der Vies
Experientia 1975
PLASMA PROGESTERONE CONCENTRATION DURING THE THIRD TRIMESTER OF DIABETIC PREGNANCY
M Booth, TA el Garf
BJOG: An International Journal of Obstetrics and Gynaecology 1974
Sex related diurnal variations in venous blood glucose and plasma insulin levels effects of estrogens in men
M Hautecouverture, G Slama, R Assan, G Tchobroutsky
Diabetologia 1974
Current Topics in Experimental Endocrinology
M Jutisz, C Tertrin-Clary
Current Topics in Experimental Endocrinology 1974
The effects of estradiol on food intake and weight in ovariectomized rats with amygdaloid lesions
VC Cox, JM King
Physiological Psychology 1974
Regulation of insulin release from isolated islets of Langerhans of the rat in pregnancy. The role of adenosine 3':5'-cyclic monophosphate
IC Green, SL Howell, W Montague, KW Taylor
Biochemical Journal 1973
Placental lactogen levels in diabetic pregnancy
W Ursell, M Brudenell, T Chard
British medical journal 1973
Influence of hormonal contraceptives on carbohydrate and lipid metabolism in the rat
E Schillinger, E Gerhards
Biochemical Pharmacology 1973
Effect of exogenous estrogen on carbohydrate metabolism in postmenopausal women
LN Ajabor, CC Tsai, P Vela, SS Yen
American Journal of Obstetrics and Gynecology 1972
The effect of estrogens on carbohydrate metabolism: Glucose, insulin, and growth hormone studies on one hundred and seventy-one women ingesting Premarin, mestranol, and ethinyl estradiol for six months
WN Spellacy, WC Buhi, SA Birk
American Journal of Obstetrics and Gynecology 1972
Plasma insulin disturbances in primary hyperparathyroidism
H Kim, RK Kalkhoff, NV Costrini, JM Cerletty, M Jacobson
Journal of Clinical Investigation 1971
Gestational diabetogenesis: Quantitative analyses of glucose-insulin interrelationship between normal pregnancy and pregnancy with gestational diabetes
SS Yen, CC Tsai, P Vela
American Journal of Obstetrics and Gynecology 1971
The Menopause
E Shorr
Bulletin of the New York Academy of Medicine 1940

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