The role of glucagon in the metabolic adaptation to prolonged fasting in man has been examined. Plasma immunoreactive glucagon was determined during 6-wk fasts and during infusion of exogenous glucagon using an assay which minimized nonpancreatic immunoreactivity.
Errol B. Marliss, Thomas T. Aoki, Roger H. Unger, J. Stuart Soeldner, George F. Cahill Jr.