Citations to this article

Blood levels and production rate of 17-hydroxypregnenolone in man
C. A. Strott, … , J. A. Bermudez, M. B. Lipsett
C. A. Strott, … , J. A. Bermudez, M. B. Lipsett
Published November 1, 1970
Citation Information: J Clin Invest. 1970;49(11):1999-2007. https://doi.org/10.1172/JCI106420.
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Research Article

Blood levels and production rate of 17-hydroxypregnenolone in man

Abstract

A reliable radio-ligand assay has been developed for the measurement of 17-hydroxypregnenolone in human peripheral vein plasma. The mean plasma concentration of 17-hydroxypregnenolone was, in men, 1.9 mμg/ml; and in women, 3.5 mμg/ml. These means were not significantly different from each other, and the levels were the same in the follicular and luteal phases of the menstrual cycle. In women, the adrenal cortex was the source of the 17-hydroxypregnenolone; in men, 40% was produced by the testis. Since the metabolic clearance rate was about 2000 liters/24 hr production rate estimates were 4-7 mg/24 hr.

Authors

C. A. Strott, J. A. Bermudez, M. B. Lipsett

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Total citations by year

Year: 2010 2001 1997 1987 1984 1980 1978 1976 1975 1973 1972 1971 Total
Citations: 1 1 1 1 1 2 1 2 1 2 2 1 16
Citation information

Citations to this article (16)

Title and authors Publication Year
Vitamins & Hormones
KJ Hare, FK Knop 		Vitamins & Hormones 2010
Automated chromatographic system for the simultaneous measurement of plasma pregnenolone and 17-hydroxypregnenolone by radioimmunoassay
FG Riepe, S Wonka, CJ Partsch, WG Sippell 		Journal of Chromatography B Biomedical Sciences and Applications 2001
Gynecological Endocrinology and Reproductive Medicine
B Runnebaum, T Rabe 		1997
21-Deoxycortisol (21-DF) and 17-hydroxyprogesterone (17-OHP) Responses to Adrenalcorticotropic Hormone in Males with Idiopathic Oligozoospermia
A Milewicz, M Medras 		Andrologia 1987
Basal and adrenocorticotropic hormone-stimulated serum 17α-hydroxyprogesterone in men with idiopathic infertility**Supported in part by a grant to John O. Ojeifo, M.D., from the Pan American Health Organization
JO Ojeifo, SJ Winters, P Troen 		Fertility and Sterility 1984
Serum 21-deoxycortisol and 17-hydroxypregnenolone in parents of patients with congenital adrenal hyperplasia
F Cassorla, A Tenore, JS Parks, J Marino, AM Bongiovanni 		Journal of Endocrinological Investigation 1980
Abnormal Adrenal Responses to Adrenocorticotropic Hormone in Hyperandrogenic Women
M Gibson, R Lackritz, I Schiff, D Tulchinsky 		Fertility and Sterility 1980
Concentrations of circulating steroids in normal prepubertal and adult male and female humans, chimpanzees, rhesus monkeys, rats, mice, and hamsters: A literature survey
JG Overpeck, SH Colson, JR Hohmann, MS Applestine, JF Reilly 		Journal of Toxicology and Environmental Health 1978
Radioimmunoassay of 17β-hydroxy-5α-androstan-3-one, 4-androstene-3,17-dione, dehydroepiandrosterone, 17-hydroxyprogesterone and progesterone and its application to human male plasma
A Vermeulen, L Verdonck 		Journal of Steroid Biochemistry 1976
Progesterone and pregnenolone 17α-hydroxylase: substrate specificity and selective inhibition by 17α-hydroxylated products
P Kremers 		Journal of Steroid Biochemistry 1976
Persistent testicular delta5-isomerase-3beta-hydroxysteroid dehydrogenase (delta5-3beta-HSD) deficiency in the delta5-3beta-HSD form of congenital adrenal hyperplasia
G Schneider, M Genel, AM Bongiovanni, AS Goldman, RL Rosenfield 		Journal of Clinical Investigation 1975
Leydig cell function in Klinefelter's syndrome
M Stewart-Bentley, R Horton 		Metabolism 1973
Diurnal variations of plasma testosterone in men
JM Barberia, J Giner, V Cortes-Gallegos 		Steroids 1973
Radioimmunoassay of Plasma 17-Hydroxypregnenolone
GE Abraham, PC Corrales, RC Teller 		Analytical Letters 1972
Radioligand assay for Δ5-3β-hydroxysteroids II. 5-androstene-3β, 17β-diol and 3β, 17α-dihydroxy-5-pregnen-20-one
DL Loriaux, MB Lipsett 		Steroids 1972
The effects of ACTH and of cortisol on serum ceruloplasmin in rabbits
AG Alias 		FEBS Letters 1971

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