Isotopic studies of therapeutic anticoagulation with a coagulating enzyme

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Abstract

The kinetics of the depletion of plasma fibrinogen were studied in seven patients who received fibrinogen-131I 1 hr before an intravenous injection of the coagulating enzyme (CE) derived from the venom of the pit viper, Agkistrodon rhodostoma. Disappearance of the clottable radioactivity labeled fibrinogen from the circulation conformed to an exponential decay with an average half-life of 0.85 hr. The mean clearance rate for protein-bound radioactivity, composed of fibrinogen and it's split products, was 12% of the intravascular pool per hour. The breakdown products of fibrin produced by CE inhibited polymerization of fibrin in vitro.

Authors

W. R. Bell, E. Regoeczi