The effect of dialysates and ultrafiltrates of plasma of saline-loaded dogs on toad bladder sodium transport

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Abstract

In order to obtain direct evidence for the existence of a natriuretic hormone, dialysates and ultrafiltrates of plasma of dogs expanded with saline were tested for effects on sodium transport by the toad urinary bladder. Dialysate was obtained by dialysis of blood in vivo in a clinical dialyzer and by dialysis in vitro of small volumes of blood using a miniature model of the clinical dialyzer. Ultrafiltrates were prepared using selective molecular filters which permit passage of substances on the basis of molecular weight and three dimensional configuration.

Authors

Vardaman M. Buckalew Jr., F. Jesus Martinez, Wesley E. Green