Catabolism of heme in vivo: comparison of the simultaneous production of bilirubin and carbon monoxide

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Abstract

The quantitative relationship between the catabolism of heme and the formation of bilirubin and carbon monoxide (CO) was studied in untreated rats and in animals treated with phenobarbital or the porphyrogenic drug, allylisopropylacetamide (AIA). A novel metabolic chamber permitting continuous collection of the bile and breath was utilized for quantitation of bilirubin-14C and 14CO after the administration of hematin-14C or glycine-14C.

Authors

Stephen A. Landaw, Edward W. Callahan Jr., Rudi Schmid