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Research Article Free access | 10.1172/JCI106275
Thorndike Memorial Laboratory, Second and Fourth (Harvard) Medical Services, Boston City Hospital, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts
Protein Research Laboratory, Bronx Veterans Administration Hospital, and the Department of Pathology, Columbia University College of Physicians and Surgeons, New York 10032
Find articles by Woeber, K. in: JCI | PubMed | Google Scholar
Thorndike Memorial Laboratory, Second and Fourth (Harvard) Medical Services, Boston City Hospital, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts
Protein Research Laboratory, Bronx Veterans Administration Hospital, and the Department of Pathology, Columbia University College of Physicians and Surgeons, New York 10032
Find articles by Sobel, R. in: JCI | PubMed | Google Scholar
Thorndike Memorial Laboratory, Second and Fourth (Harvard) Medical Services, Boston City Hospital, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts
Protein Research Laboratory, Bronx Veterans Administration Hospital, and the Department of Pathology, Columbia University College of Physicians and Surgeons, New York 10032
Find articles by Ingbar, S. in: JCI | PubMed | Google Scholar
Thorndike Memorial Laboratory, Second and Fourth (Harvard) Medical Services, Boston City Hospital, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts
Protein Research Laboratory, Bronx Veterans Administration Hospital, and the Department of Pathology, Columbia University College of Physicians and Surgeons, New York 10032
Find articles by Sterling, K. in: JCI | PubMed | Google Scholar
Published April 1, 1970 - More info
In order to assess the contribution of 3.3′,5-triiodo-L-thyronine (T3) to overall thyroid hormone economy, conjoint measurements of the kinetics of peripheral T3 metabolism and the total concentration of T3 in serum were made in a group of normal subjects and in a group of patients with hyperthyroid Graves' disease. As judged from the disappearance of trichloroacetic acid-precipitable 131I from serum after a single intravenous dose of labeled T3, the following mean values were obtained in the normal subjects: volume of distribution, 43 liters or 0.62 liter/kg; fractional turnover rate. 52% per 24 hr: clearance rate, 22.3 liters/24 hr: and absolute disposal rate, 60 μg/24 hr. In the patients with untreated hyperthyroidism, values for all these functions were greatly increased. After treatment, the volume of T3 distribution returned to normal but the fractional turnover rate remained abnormally rapid.