Defect in urinary acidification induced in vitro by amphotericin B

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Abstract

An experimental defect in urinary acidification was induced in the isolated turtle bladder by amphotericin B and the nature of the defect was examined. Net hydrogen ion secretion was little affected by amphotericin when passive electrochemical forces across the epithelium were held at a minimum in the short-circuited state under isohydric conditions. Hydrogen ion secretion against a gradient, however, was markedly reduced by amphotericin and abolished at gradients of more than 2 pH units.

Authors

Philip R. Steinmetz, Lois R. Lawson