Studies on the pathogenesis of acute inflammation: IX. The influence of hyperosmolality secondary to hyperglycemia upon the acute inflammatory response induced by thermal injury to ear chambers of rabbits

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Abstract

The inflammatory reaction induced in ear chambers of rabbits by heat injury was studied in nondiabetic animals made hyperglycemic with continuous infusions of glucose. Hypertonic solutions of glucose administered intravenously to rabbits induced the following triad: hyperglycemia, hyperosmolality, and metabolic lactic acidosis. It was found that relatively short periods of this metabolic abnormality were associated with a significant reduction in the intensity of the inflammatory reaction.

Authors

Sterling K. Ainsworth, Fred Allison Jr.