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Citations to this article

The effects of deoxygenation of adult and fetal hemoglobin on the synthesis of red cell 2,3-diphosphoglycerate and its in vivo consequences
Frank A. Oski, … , William W. Miller, Maria Delivoria-Papadopoulos
Frank A. Oski, … , William W. Miller, Maria Delivoria-Papadopoulos
Published February 1, 1970
Citation Information: J Clin Invest. 1970;49(2):400-407. https://doi.org/10.1172/JCI106249.
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Research Article

The effects of deoxygenation of adult and fetal hemoglobin on the synthesis of red cell 2,3-diphosphoglycerate and its in vivo consequences

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Abstract

Patients over 1 month of age with arterial oxygen pressures of less than 60 mm Hg were found to have elevated red cell 2,3-diphosphoglycerate (2,3-DPG) levels and blood with a decreased affinity for oxygen. The increase in 2,3-DPG was proportional to the degree of hypoxemia. In patients under 1 month of age this relationship was not observed. Red cells from adults, but not newborns, showed rapid increases in 2,3-DPG when incubated under nitrogen. Adult, but not fetal, deoxyhemoglobin was shown to facilitate in vitro synthesis of 2,3-DPG by binding this organic phosphate and relieving the product inhibition of 2,3-DPG mutase.

Authors

Frank A. Oski, Arlan J. Gottlieb, William W. Miller, Maria Delivoria-Papadopoulos

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Total citations by year

Year: 2025 2021 2019 2018 2014 2012 2011 2007 2004 2001 1998 1997 1991 1987 1986 1984 1983 1980 1979 1978 1977 1976 1975 1974 1973 1972 1971 1970 Total
Citations: 1 1 1 1 1 1 1 1 1 1 1 2 1 1 2 3 2 1 3 2 2 9 3 8 7 5 12 4 78
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Citations to this article (79)

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