Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

The effect of sodium taurocholate on the hepatic metabolism of sulfobromophthalein sodium (BSP). The role of bile flow
J. L. Boyer, … , R. L. Scheig, G. Klatskin
J. L. Boyer, … , R. L. Scheig, G. Klatskin
Published February 1, 1970
Citation Information: J Clin Invest. 1970;49(2):206-215. https://doi.org/10.1172/JCI106229.
View: Text | PDF
Research Article

The effect of sodium taurocholate on the hepatic metabolism of sulfobromophthalein sodium (BSP). The role of bile flow

  • Text
  • PDF
Abstract

The influence of bile salts on the hepatic metabolism of sulfobromophthalein sodium (BSP) was studied in the perfused rat liver. During sodium taurocholate infusions, hepatic uptake of BSP from plasma was increased and appeared to be related to an enhanced transit of BSP from liver into bile. BSP-glutathione conjugation was not affected by the bile salt infusions, although bile salts inhibited the enzyme system in vitro.

Authors

J. L. Boyer, R. L. Scheig, G. Klatskin

×

Total citations by year

Year: 2021 2020 2017 2012 1999 1992 1991 1990 1989 1988 1987 1985 1984 1983 1982 1981 1980 1979 1978 1977 1976 1975 1974 1973 1972 1971 1970 1962 Total
Citations: 1 1 1 1 1 2 1 1 1 1 3 1 4 1 4 3 1 3 5 4 6 2 6 2 1 1 2 1 61
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (61)

Title and authors Publication Year
Intravital Dynamic and Correlative Imaging of Mouse Livers Reveals Diffusion‐Dominated Canalicular and Flow‐Augmented Ductular Bile Flux
N Vartak, G Guenther, F Joly, A DamleVartak, G Wibbelt, J Fickel, S Jörs, B BegherTibbe, A Friebel, K Wansing, A Ghallab, M Rosselin, N Boissier, I VignonClementel, C Hedberg, F Geisler, H Hofer, P Jansen, S Hoehme, D Drasdo, JG Hengstler
Hepatology 2021
Highlight report: New insights in liver physiology: Canalicular bile flux is diffusion dominated
Ahmed Ezzat Ahmed
EXCLI J 2020
Pharmacokinetics of Jaspine B and Enhancement of Intestinal Absorption of Jaspine B in the Presence of Bile Acid in Rats
MK Choi, J Lee, S Nam, Y Kang, Y Han, K Choi, Y Choi, M Kwon, D Lee, IS Song
Marine drugs 2017
Induction of multidrug resistance-associated protein 2 in liver, intestine and kidney of streptozotocin-induced diabetic rats
D Mei, J Li, H Liu, L Liu, X Wang, H Guo, C Liu, R Duan, X Liu
Xenobiotica 2012
Vasoactive intestinal polypeptide is a potent regulator of bile secretion from rat cholangiocytes
WK Cho, JL Boyer
Gastroenterology 1999
An improved technique for isolated perfusion of rat livers and an evaluation of perfusates
HJ Mischinger, TR Walsh, T Liu, PN Rao, R Rubin, K Nakamura, S Todo, TE Starzl
The Journal of surgical research 1992
Lipid flow in bile formation
R Coleman, K Rahman
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1992
Hepatic clearance and biliary secretory rate maximum of taurocholate in the recirculating and single pass isolated perfused rat liver
M Vore, S Durham, S Yeh, T Ganguly
Biochemical Pharmacology 1991
Taurocholate stimulates transcytotic vesicular pathways labeled by horseradish peroxidase in the isolated perfused rat liver
T Hayakawa, O Cheng, A Ma, JL Boyer
Gastroenterology 1990
Taurocholate increases the biliary output of bilirubin pigments in the rat, due to haemolysis
VA Mesa, JD Groote, J Fevery
Journal of Hepatology 1989
Interindividual variability in biliary excretion of ceftriaxone: effects on biliary lipid metabolism and on intestinal microflora
A Arvidsson, B Leijd, CE Nord, B Angelin
European Journal of Clinical Investigation 1988
The kinetics of sulfobromophthalein uptake by rat liver sinusoidal vesicles
BJ Potter, BF Blades, MD Shepard, SM Thung, PD Berk
Biochimica et Biophysica Acta (BBA) - Biomembranes 1987
Transport of conjugated bilirubin and other organic anions in bile: relation to biliary lipid structures
S Tazuma, RT Holzbach
Proceedings of the National Academy of Sciences 1987
Membrane Transport Processes in Organized Systems
TE Andreoli, JF Hoffman, DD Fanestil, SG Schultz
1987
Effects of ioglycamide on the hepatic transport of bilirubin and its mono- and diconjugates in the rat
VA Mesa, J Fevery, KP Heirwegh, JD Groote
Hepatology 1985
EFFECT OF INCREASED BILE FLOW AND BILE ACID SECRETION ON THE HEPATIC ELIMINATION OF SODIUM VALPROATE IN THE CAT
AW Marshall, GW Mihaly, RA Smallwood, RG Hanson, FJ Vajda, J Phillips, J Baldas
Clinical and Experimental Pharmacology and Physiology 1984
Bile Secretion in Hemoglobin-Free Perfused Rat Liver
H KRELL, H JÄSCHKE, H HÖKE, E PFAFF
Hoppe-Seyler´s Zeitschrift für physiologische Chemie 1984
Biliary secretion and hepatic metabolism of taurine-conjugated 7α-hydroxy and 7β-hydroxy bile acids in the dog
M Nakagaki, RG Danzinger, AF Hofmann, RA DiPietro
Gastroenterology 1984
Pharmacokinetics of the hepatic transport of organic anions: influence of extra- and intracellular binding on hepatic storage of dibromosulfophthalein and interactions with indocyanine green.
Meijer DK, Blom A, Weitering JG, Hornsveld R
Journal of Pharmacokinetics and Biopharmaceutics 1984
Biological Basis of Detoxication
WG Levine
Biological Basis of Detoxication 1983
Effects of ion substitution on bile acid-dependent and -independent bile formation by rat liver
RW van Dyke, JE Stephens, BF Scharschmidt
Journal of Clinical Investigation 1982
Taurocholate Transport by Rat Liver Sinusoidal Membrane Vesicles: Evidence of Sodium Cotransport
M Inoue, R Kinne, T Tran, IM Arias
Hepatology 1982
Hepatic drug transport in the rat
A Blom, AH Scaf, DK Meijer
Biochemical Pharmacology 1982
Effects of taurocholate on the size of mixed lipid micelles and their associations with pigment and proteins in rat bile
A Reuben, KE Howell, JL Boyer
Journal of lipid research 1982
Biliary excretion of sulfobromophthalein compounds in normal and mutant corriedale sheep. Evidence for a disproportionate transport defect for conjugated sulfobromophthalein
JL Barnhart, RR Gronwall, B Combes
Hepatology 1981
Transport of dibromosulphthalein by isolated rat hepatocytes
A Blom, K Keulemans, DK Meijer
Biochemical Pharmacology 1981
Experimental hepatobiliary injury: Comparison ofin vivo drug elimination within vitro drug-metabolizing enzyme capacity in the rat
RA Willson, FE Hart, JT Hew
Digestive Diseases and Sciences 1981
Phalloidin-induced cholestasis: a microfilament-mediated change in junctional complex permeability
E Elias, Z Hruban, JB Wade, JL Boyer
Proceedings of the National Academy of Sciences 1980
Influence of taurocholate, taurochenodeoxycholate, and taurodehydrocholate on sulfobromophthalein transport into bile
S Binet, Y Delage, S Erlinger
American journal of physiology. Endocrinology and metabolism 1979
Influence of bile salts on hepatic transport of dibromosulphthalein
RJ Vonk, M Danhof, T Coenraads, AB van Doorn, K Keulemans, AH Scaf, DK Meijer
American journal of physiology. Endocrinology and metabolism 1979
Choleresis and cholestasis produced by infusion of taurocholic acid or taurodehydrocholic acid combined with BSP in the rhesus monkey
TJ Hall, AL Baker, MJ Cooper, AR Moossa
Digestive Diseases and Sciences 1979
The Micellar Sink A QUANTITATIVE ASSESSMENT OF THE ASSOCIATION OF ORGANIC ANIONS WITH MIXED MICELLES AND OTHER MACROMOLECULAR AGGREGATES IN RAT BILE
BF Scharschmidt, R Schmid
Journal of Clinical Investigation 1978
Effect of Tilorone Hydrochloride on Hepatic Disposition of Sulphobromophthalein (BSP) in the Rat
V Hoenig, F Werner
Xenobiotica 1978
The dual effect of glycocholate on hepatic dihydroxy bile acid excretion
IJ Sarfeh, SE Friday, JA Balint
Journal of Surgical Research 1978
Hemodynamic effects on determinants of bile secretion in isolated rat liver
N Tavoloni, JS Reed, JL Boyer
American journal of physiology. Endocrinology and metabolism 1978
Physiology of Membrane Disorders
TE Andreoli, JF Hoffman, DD Fanestil
1978
Effect of porphyrinogenic agents on protein synthesis and bilirubin formation by the isolated perfused rat liver
HH Liem, K Miyai, U Muller-Eberhard
Biochimica et Biophysica Acta (BBA) - General Subjects 1977
Facilitation of hepatic uptake of phenol 3,6-dibromphthalein disulfonate by taurocholate
Y Marinovic, JC Glasinovic, B Semelle, JF Boivieux, S Erlinger
American journal of physiology. Endocrinology and metabolism 1977
Biliary transport of cholephilic dyes: evidence for two different pathways
JL Mahu, P Duvaldestin, D Dhumeaux, P Berthelot
American journal of physiology. Endocrinology and metabolism 1977
Choleresis and hepatic transport mechanisms: III. Binding of ouabain and K-strophanthoside to biliary micelles and influence of choleresis on their biliary excretion
RJ Vonk, AB van Doorn, AH Scaf, DK Meijer
Naunyn-Schmiedeberg's Archives of Pharmacology 1977
Zur Physiologie der Galleexkretion des gallegängigen Kontrastmittels Joglycamid beim Zwergschwein unter besonderer Berücksichtigung der Bedeutung des Galleflusses
R Klapdor, H Valerius, N Zschukke
Research in Experimental Medicine 1976
The effect of bucolome on the canalicular bile formation and sulfobromophthalein transport maximum in the dog
K Kenichi, T Setsuko, M Reiko, M Yoshiko
Biochemical Pharmacology 1976
Röntgendiagnostik der Leber und der Gallenwege Teil 1 / Roentgen Diagnosis of the Liver and Biliary System Part 1
P Blaszkiewicz, FJ Herrmann, A Lunderquist, B Mateev, G Meyer, W Münster, J Rösch, N Rupp, B Swart, W Wirbatz, F Heuck
1976
The Hepatobiliary System
W Taylor
1976
Hepatic Functional Deterioration After Portacaval Shunt in the Rat
BH Lauterburg, V Sautter, R Preisig, J Bircher
Gastroenterology 1976
Reply of the authors
R Utill, CO Abernathy, HJ Zimmerman
Gastroenterology 1976
Temperature sensitivity of bromosulphophthalein clearance by the liver
PJ Harris, AR Noble, KA Munday
Experientia 1975
Choleresis and hepatic transport mechanisms: II. Influence of bile salt choleresis and biliary micelle binding on biliary excretion on various organic anions
RJ Vonk, P Jekel, DK Meijer
Naunyn-Schmiedeberg's Archives of Pharmacology 1975
Canalicular Bile Secretion in Man STUDIES UTILIZING THE BILIARY CLEARANCE OF [14C]MANNITOL
JL Boyer, JR Bloomer
Journal of Clinical Investigation 1974
Variation in hepatic bile composition following cholecystectomy in patients with previous gallstones
JL Boyer, JR Bloomer, WC Maddrey, D Tilson
The Yale journal of biology and medicine 1974
The influence of taurocholate and dehydrocholate choleresis on plasma disappearance and biliary excretion of indocyanine green in the rat
RJ Vonk, H v. d. Veen, G Prop, DK Meijer
Naunyn-Schmiedeberg's Archives of Pharmacology 1974
Mechanisms and Control of Secretion of Bile Water and Electrolytes
S Erlinger, D Dhumeaux
Gastroenterology 1974
Canalicular Bile Flow and Bromosulfophthalein Transport Maximum: The Effect of a Bile Salt-Independent Choleretic, Sc-2644
GE Gibson, EL Forker
Gastroenterology 1974
A Comparison Between the Bile Acid Concentration and the Inorganic Cation-Anion Difference in Dog Bile
K Kutz, G Paumgartner, G Egger, R Preisig
Gastroenterology 1974
The excretory capacity of the isolated rat liver: An in vitro ? in vivo comparison
R Herz, B Cueni, J Bircher, G Paumgartner
Naunyn-Schmiedeberg's Archives of Pharmacology 1973
Bile Salts: A Determinant of the Bile-Peritoneal Electrical Potential Difference in the Rat
HJ Binder, JL Boyer
Gastroenterology 1973
Effect of Chronic Ethanol Feeding on Bile Formation and Secretion of Lipids in the Rat
JL Boyer
Gastroenterology 1972
Cholestasis induced by sodium taurolithocholate in isolated hamster liver
JE King, LJ Schoenfield
Journal of Clinical Investigation 1971
Production of lecithin: cholesterol acyltransferase by the isolated perfused rat liver
JB Simon, JL Boyer
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1970
Canalicular Bile flow and Bile Secretory Pressure
JL Boyer, G Klatskin
Gastroenterology 1970
Jaundice
S Sherlock
British medical journal 1962

← Previous 1 2 3 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts