Citations to this article

DNA polymerase activity as an index of lymphocyte stimulation: studies in Down's syndrome
S. S. Agarwal, … , Alton I. Sutnick, Lawrence A. Loeb
S. S. Agarwal, … , Alton I. Sutnick, Lawrence A. Loeb
Published January 1, 1970
Citation Information: J Clin Invest. 1970;49(1):161-169. https://doi.org/10.1172/JCI106215.
View: Text | PDF
Research Article

DNA polymerase activity as an index of lymphocyte stimulation: studies in Down's syndrome

Abstract

The ability of peripheral blood lymphocytes to respond to phytohemagglutinin (PHA) in vitro was studied in patients with Down's syndrome. The response was measured by the increase in DNA polymerase activity and the rate of incorporation of tritiated thymidine by the cultured lymphocytes. These activities were significantly lower in PHA-stimulated lymphocytes from patients with Down's syndrome compared with age- and sex-matched, mentally retarded patients without Down's syndrome from the same institution and the normal healthy volunteers. The impairment in response to PHA does not seem to be related to the presence of Australia antigen in patients with Down's syndrome or to institutionalization itself. In contrast to DNA polymerase activity and thymidine-3H uptake, there was no significant difference in the percentage of blast transformation in the three groups studied. The poor response of the lymphocytes from patients with Down's syndrome to a mitogenic stimulus could reflect an impairment of cellular immune functions in these patients which may be one of the factors contributing to the vulnerability of these patients to repeated or persistent infections.

Authors

S. S. Agarwal, Baruch S. Blumberg, Betty Jane S. Gerstley, W. Thomas London, Alton I. Sutnick, Lawrence A. Loeb

×

Total citations by year

Year: 2020 2018 2016 2011 2009 1994 1992 1990 1988 1987 1983 1982 1981 1980 1979 1978 1977 1976 1975 1974 1973 1972 1971 1970 Total
Citations: 1 1 1 1 2 1 1 1 2 1 3 2 3 3 1 6 2 3 3 3 4 4 3 7 59
Citation information

Citations to this article (59)

Title and authors Publication Year
Cellular Senescence in Neurodegenerative Diseases
C Martínez-Cué, N Rueda 		Frontiers in cellular neuroscience 2020
Loss of DNA polymerase β induces cellular senescence: DNA Polymeraseβ Deficiency Drives Senescence
AA Ahmed, C Smoczer, B Pace, D Patterson, DC Cabelof 		Environmental and Molecular Mutagenesis 2018
Etiology of Acute Leukemias in Children
JM Mejía-Aranguré 		2016
Down syndrome as a model of DNA polymerase beta haploinsufficiency and accelerated aging
D Patterson, DC Cabelof 		Mechanisms of Ageing and Development 2011
Intrinsic defect of the immune system in children with Down syndrome: a review
MA Kusters, RH Verstegen, EF Gemen, E Vries 		Clinical & Experimental Immunology 2009
Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome
DC Cabelof, HV Patel, Q Chen, H Remmen, LH Matherly, Y Ge, JW Taub 		Blood 2009
Oral zinc supplementation in Down's syndrome subjects decreased infections and normalized some humoral and cellular immune parameters
F Licastro, M Chiricolo, E Mocchegiani, N Fabris, M Zannoti, E Beltrandi, R Mancini, R Parents, G Arena, M Masi 		Journal of Intellectual Disability Research 1994
The effect of aging on cell-cycle kinetics and X-ray-induced chromosome aberrations in cultured lymphocytes from patients with Down syndrome
T Takeshita, C Ariizumi-Shibusawa, K Shimizu, H Hoshino, Z Yamagata, S Iijima, A Asaka, M Higurashi 		Mutation Research/DNAging 1992
Intrathymic deficient expansion of T cell precursors in Down syndrome
P Musiani, S Valitutti, F Castellino, LM Larocca, N Maggiano, M Piantelli 		American Journal of Medical Genetics 1990
Clinical Approach to Infection in the Compromised Host
RH Rubin, LS Young 		1988
Cell-mediated cytotoxicity in down syndrome: impairment of allogeneic mixed lymphocyte reaction, NK and NK-like activities
D Montagna, R Maccario, AG Ugazio, L Nespoli, E Pedroni, P Faggiano, GR Burgio 		European Journal of Pediatrics 1988
Down's syndrome and leukemia: Epidemiology, genetics, cytogenetics and mechanisms of leukemogenesis
C Fong, GM Brodeur 		Cancer Genetics and Cytogenetics 1987
The influence of cell cycle kinetics on the radiosensitivity of Down's syndrome lymphocytes
JC Leonard, T Merz 		Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 1983
Sister chromatid exchange and lym phocyte proliferation in a Down syndrome mosaic
A Heidemann, B Schmalenberger, H Zankl 		Clinical Genetics 1983
Advances in Radiation Biology
SK Calderwood, JA Dickson 		Advances in Radiation Biology 1983
Bleomycin-induced chromosomal aberrations in Down's syndrome lymphocytes
Vijayalaxmi, HJ Evans 		Mutation Research Letters 1982
Immunological and virological investigations in Down's syndrome
G Fekete, G Kulcsr, P Dn, I Nsz, D Schuler, M Dobos 		European Journal of Pediatrics 1982
Decreased Cord Blood IgM and IgA in Trisomy 21*
LL Cederqvist, S Spigelman, SD Litwin 		American Journal of Reproductive Immunology 1981
Advances in Cellular Neurobiology
MD Norenberg 		Advances in Cellular Neurobiology 1981
Trisomy 21
GR Burgio, M Fraccaro, L Tiepolo, U Wolf 		1981
ZINC AND IMMUNE FUNCTION IN DOWN'S SYNDROME
B Björkstén, O Bäck, KH Gustavson, G Hallmans, B Hägglöf, A Tärnvik 		Acta Paediatrica 1980
T-lymphocyte function and sensitivity to interferon in trisomy 21
LB Epstein, CJ Epstein 		Cellular Immunology 1980
Lymphocyte proliferation in Down's syndrome measured by sister chromatid differential staining
PE Crossen, WF Morgan 		Human Genetics 1980
DNA polymerase activity in proliferating and antigen-stimulated tissues
MG Battelli, C Franceschi, F Novello, F Stirpe 		Experimental and Molecular Pathology 1979
T AND B LYPMHOCYTE SUBPOPULATIONS IN DOWN'S SYNDROME. A STUDY ON NON-INSTITUTIONALISED SUBJECTS
C Franceschi, F Licastro, P Paolucci, M Masi, S Cavicchi, M Zannotti 		Journal of Intellectual Disability Research 1978
Phospholipid composition of Down's syndrome and normal platelets
K Strynadka, EE McCoy 		Clinical Biochemistry 1978
Lymphoblastogenesis in Down's syndrome and its inhibition by human interferon
D Gurari-Rotman, M Revel, B Tartakovsky, S Segal, T Hahn, Z Handzel, S Levin 		FEBS Letters 1978
Immunity in Down's syndrome
GR Burgio, AG Ugazio 		European Journal of Pediatrics 1978
The Pathologic Physiology of Dementia
RM Torack 		1978
Kinetics of 21-trisomic lymphocytes: I. In vitro response of 21-trisomic lymphocytes to PHA
A Serra, E Arpaia, R Bova 		Human Genetics 1978
Cellular immunity in newborn infants and children: stimulation of lymphocyte protein synthesis as a measure of immune competence
B Schechter, ZT Handzel, Y Altman, E Nir, S Levin 		Clinical & Experimental Immunology 1977
On the influence of age on immunity in Down's syndrome
R Seger, G Buchinger, J Strder 		European Journal of Nuclear Medicine 1977
DNA repair and frequency of X-ray and u.v.-light induced chromosome aberrations in leukocytes from patients with Down's syndrome
B Lambert, K Hansson, TH Bui, F Funes-Cravioto, J Lindsten, M Holmberg, R Strausmanis 		Annals of Human Genetics 1976
DNA Repair and Human Disease
B Lambert, U Ringborg 		Acta Medica Scandinavica 1976
Immune Reactivity of Lymphocytes
M Feldman, A Globerson 		1976
Serial Studies of Hepatitis-Associated Antigen and Antibody in Patients Receiving Antitumor Chemotherapy for Myeloproliferative and Lymphoproliferative Disorders
JR Wands, CM Chura, FJ Roll, WC Maddrey 		Gastroenterology 1975
AUSTRAUA ANTIGEN, AUTOANTmODIES AND CELL‐MEDIATED IMMUNE RESPONSES IN PATIENTS WITH DOWN'S SYNDROME
EC Campion, AG Wangel 		The Medical Journal of Australia 1975
Thymus-derived lymphocytes in type B acute viral hepatitis and healthy carriers of hepatitis B surface antigen (HBsAg).
Wicks RC, Kohler PF, Singleton JW 		The American Journal of Digestive Diseases 1975
Peripheral blood ‘Rosette forming lymphocytes’ in Down's syndrome
GR Burgio, AG Ugazio, L Nespoli 		Experientia 1974
Inability to detect hepatitis B virus or specific antigens in transformed chimpanzee lymphocytes
CA Schable, BL Murphy, KR Berquist, CR Gravelle, JE Maynard 		Infection and immunity 1974
Immunologic reactions and Australia Antigenemia in Down's Syndrome
DR Hollingsworth, JW Hollingsworth, I Roeckel, HE McKean, N Holland 		Journal of Chronic Diseases 1974
" FORBIDDEN CLONES " AND AUTOIMMUNITY
KO Cox, D Keast 		The Lancet 1973
LYMPHOCYTE TRANSFORMATION AND PERSISTENT AUSTRALIA ANTIGEN
AI Sutnick, WT London, BS Blumberg 		The Lancet 1973
Persistent viral hepatitis
NB Javitt, R Hand, ND Finlayson 		The American Journal of Medicine 1973
Australia Antigen: Progress Report
AI Sutnick 		Medical Clinics of North America 1973
Lymphocyte Antigens in Patients with Down's Syndrome
LA Boxer, M Yokoyama 		Vox Sanguinis 1972
Gm antigenic titres in adults with Down's syndrome (mongolism), non-mongoloid mental defectives and healthy blood donors
H Thom, E McKay 		Clinical & Experimental Immunology 1972
Down's syndrome and acute leukemia: Myeloblastic or lymphoblastic?
F Rosner, SL Lee 		The American Journal of Medicine 1972
Studies on the Australia antigen: I. Associations between Australia antigen and leprosy
R Ananthakrishnan, A Arndt-Hanser, H Walter 		Human Genetics 1972
FREQUENCY OF AUSTRALIA ANTIGEN IN PATIENTS WITH LEUKÆMIA IN DIFFERENT COUNTRIES
AI Sutnick, WT London, PH Levine, BS Blumberg 		The Lancet 1971
Susceptibility of chromosomes from patients with Down's syndrome to 7,12-dimethylbenz(a) anthracene-induced aberrationsin vitro
RL O'Brien, P Poon, E Kline, JW Parker 		International Journal of Cancer 1971
Australia Antigen and Hepatitis: A Comprehensive Review
BS Blumber, AI Sutnick, WT London, I Millman 		Critical Reviews in Clinical Laboratory Sciences 1971
AUSTRALIA ANTIGEN, HEPATITIS VIRUS AND DOWNS SYNDROME
BS Blumberg, BJ Gerstley, AI Sutnick, I Millman, WT London 		Annals of the New York Academy of Sciences 1970
Induction of DNA Polymerase in Mixed Lymphocyte Cultures
SS Agarwal, SJ Bugbee, LA Loeb 		Nature 1970
New Immunologic Relationships of Australia Antigen
AI Sutnick, VK Raunio, WT London, I Millman, BS Blumberg 		Vox Sanguinis 1970
Epidemiology of viral hepatitis
RS M.D., PK M.D. 		C R C Critical Reviews in Environmental Control 1970
Lepromatous leprosy and australia antigen with comments on the genetics of leprosy
BS Blumberg, L Melartin, R Guinto, M Lechat 		Journal of Chronic Diseases 1970
Viral Hepatitis: Revised Concepts as a Result of the Study of Australia Antigen
AI Sutnick, WT London, I Millman, VE Coyne, BS Blumberg 		The Medical clinics of North America 1970
Australia (hepatitis-associated) antigen: physicochemical and immunological characteristics.
Le Bouvier GL, McCollum RW 		Advances in virus research 1970

Advertisement