Dopamine (3-Hydroxytyramine) metabolism in parkinsonism

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Abstract

Three patients with idiopathic parkinsonism and six normal subjects were infused over a 4 hr period with 104.6 μc of dopamine-2-14C (3,4-dihydroxyphenylethylamine, 3-hydroxytyramine),1 the immediate precursor in the synthesis of the sympathetic neurohormone, noradrenaline (norepinephrine). Urine was collected during the infusion period, 0-2 hr, 2-4 hr, 4-8 hr, 8-24 hr, and thereafter for 4 additional days. Using a technique herein described, the various metabolic and biosynthetic products of dopamine, including noradrenaline and its metabolic products, were separated, identified, and their radioactivity measured.

Authors

McC. Goodall, Harold Alton