Citations to this article

Treatment of leukemia with large doses of methotrexate and folinic acid: clinical-biochemical correlates
William M. Hryniuk, Joseph R. Bertino
William M. Hryniuk, Joseph R. Bertino
Published November 1, 1969
Citation Information: J Clin Invest. 1969;48(11):2140-2155. https://doi.org/10.1172/JCI106181.
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Research Article

Treatment of leukemia with large doses of methotrexate and folinic acid: clinical-biochemical correlates

Abstract

Patients with acute leukemia were given repeated cycles consisting of infusions of methotrexate followed by “rescue” with folinic acid. Peripheral blood leukemic cells were harvested from patients before cyclical treatment, and the rates of incorporation of thymidine and of deoxyuridine into deoxyribonucleic acid (DNA) were measuared in vitro. There was no relationship between the pretreatment incorporation of either deoxynucleoside into DNA and the clinical response to therapy. Methotrexate suppressed deoxyuridine incorporation into DNA by the leukemic blasts in vitro, but the patients whose cells were most sensitive to this effect did not necessarily go into remission when treated.

Authors

William M. Hryniuk, Joseph R. Bertino

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WR Shapiro, DF Young, BM Mehta 		New England Journal of Medicine 1975
Interaction of methotrexate with lipotropic factors in rat liver
DJ Tuma, AJ Barak, MF Sorrell 		Biochemical Pharmacology 1975
The effect of external deoxyribonucleosides on deoxyribonucleoside triphosphate concentrations in human lymphocytes
MH Tattersall, K Ganeshaguru, AV Hoffbrand 		Biochemical Pharmacology 1975
Antineoplastic and Immunosuppressive Agents
AC Sartorelli, DG Johns 		1975
The mechanisms of action of three fluorine substituted cytosine analogs: Implications for cancer chemotherapy
MH Tattersall, K Ganeshaguru, AV Hoffbrand 		Biochemical Pharmacology 1974
Threshold Methotrexate Concentration for In Vivo Inhibition of DNA Synthesis in Normal and Tumorous Target Tissues
BA Chabner, RC Young 		Journal of Clinical Investigation 1973
Transport of Methotrexate into Normal Haemopoietic Cells and into Leukaemic Cells and its Effects on DNA Synthesis
AV Hoffbrand, E Tripp, D Catovsky, KC Das 		British Journal of Haematology 1973
Chemotherapy of cancer of the head and neck
JR Bertino, MB Mosher, RC Deconti 		Cancer 1973
Development of a combination chemotherapy program for adult acute leukemia: CAM and CAM-L
RT Skeel, JC Marsh, RC Deconti, MS Mitchell, S Hubbard, JR Bertino 		Cancer 1973
�ber eine neue Methode zur quantitativen Bestimmung, Reinheitspr�fung und Stabilit�tsmessung von Calcium-Leucovorin
H Suter, J Conti, M Litmanowitsch, A Grossmann, A Hedinger 		Helvetica Chimica Acta 1973
Problem Clinic
HS Carlin 		Hospital Topics 1972
Effective Absorption and Utilization of Oral Formyltetrahydrofolate in Man
PF Nixon, JR Bertino 		New England Journal of Medicine 1972
Leukämie
R Gross, J van de Loo 		1972
STABILIZATION OF DIHYDROFOLATE REDUCTASE BY INHIBITORS IN VIVO AND IN VITRO
BL Hillcoat, L Marshall, J Gauldie, M Hiebert 		Annals of the New York Academy of Sciences 1971
Toxic and therapeutic effects of methotrexate-folinic acid (leucovorin) in advanced cancer and leukemiaWriting committee for the southeastern cancer study group
WR Vogler, J Jacobs 		Cancer 1971
DISCUSSION PAPER: L-ASPARAGINASE INDUCED ALTERATION OF AMETHOPTERIN (METHOTREXATE) ACTIVITY IN MOUSE LEUKEMIA L5178Y
RL Capizzi, WP Summers, JR Bertino 		Annals of the New York Academy of Sciences 1971
NEW APPROACHES TO CHEMOTHERAPY WITH FOLATE ANTAGONISTS: USE OF LEUCOVORIN "RESCUE" AND ENZYMIC FOLATE DEPLETION
JR Bertino, M Levitt, JL McCullough, B Chabner 		Annals of the New York Academy of Sciences 1971
DISCUSSION PAPER: STUDIES WITH A 2,4-DIAMINO-5-CHLORO-QUINAZOLINE ANTIFOLATE: IN VITRO AND IN VIVO CORRELATES IN NORMAL AND LYMPHOSARCOMA DOGS
E Fölsch, G Abboud, E Gralla, JR Bertino 		Annals of the New York Academy of Sciences 1971
GROWTH RATE AND CELL KILL
WM Hryniuk, JR Bertino 		Annals of the New York Academy of Sciences 1971
Synthesis of (±)-5,10-methenyltetrahydrofolic acid-214C and (±)-5-formyltetrahydrofolic acid-214C
JR Beavon, JA Blair 		Analytical Biochemistry 1971
Current Concepts in the Management of Lymphoma and Leukemia
JE Ultmann, ML Griem, WH Kirsten, RW Wissler 		1971
Transport of Nitrogen Mustard on the Transport-Carrier for Choline in L5178Y Lymphoblasts
GJ Goldenberg, CL Vanstone, I Bihler 		Science 1971
Differential diagnosis and management of the patient with megaloblastic anemia
LW Sullivan 		The American Journal of Medicine 1970
Drugs, toxins and dietary amino acids affecting vitamin B12 or folic acid absorption or utilization
S Waxman, JJ Corcino, V Herbert 		The American Journal of Medicine 1970
Quinazoline antifolates as inhibitors of dihydrofolate reductase from human leukemia cells
DG Johns, RL Capizzi, A Nahas, AR Cashmore, JR Bertino 		Biochemical Pharmacology 1970

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