Effect of adenosine 3′,5′-monophosphate on production of glucose and ammonia by renal cortex

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Abstract

In studies employing rat renal cortical slices, the addition of adenosine 3′,5′-monophosphate (cyclic AMP) to the incubation medium caused an increase in production of glucose from glutamine, glutamate, α-ketoglutarate, fumarate, malate, and oxalacetate, but not from glycerol and fructose. These observations suggest that cyclic AMP accelerates a rate-limiting gluconeogenic reaction between oxalacetate and the triose phosphates. The addition to the medium of parathyroid hormone, which is known to increase renal cortical cyclic AMP, also stimulated glucose production from glutamine.

Authors

Anthony S. Pagliara, A. David Goodman