The characteristics of ribonucleic acid (RNA) degradation in intact reticulocytes have been investigated. The rate of degradation during in vitro maturation at 37°C is approximately 4% per hr. RNA degradation does not proceed at 0°C, and the rate of degradation is temperature dependent with an optimum at 50°C. The process is not dependent upon glycolysis. Although all types of RNA progressively decrease during in vivo maturation, ribosomes are degraded at a rate greater than that of soluble RNA.
Edward R. Burka
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Enhanced stability and polyadenylation of select mRNAs support rapid thermogenesis in the brown fat of a hibernator: ( A ) Schematic depicting the metabolic suppression and activation cycle of BAT during the highly recruited, winter hibernation phase (blue shading) of the annual cycle. Cartoon squirrels represent general phenotypic changes among annual and torpor–arousal cycles (Hindle and Martin, 2014). ( B ) Relationship of sample groups to body temperature over time. Blue highlighting on months indicates hibernation
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