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Citations to this article

A lipoprotein characterizing obstructive jaundice. I. Method for quantitative separation and identification of lipoproteins in jaundiced subjects
D. Seidel, … , P. Alaupovic, R. H. Furman
D. Seidel, … , P. Alaupovic, R. H. Furman
Published July 1, 1969
Citation Information: J Clin Invest. 1969;48(7):1211-1223. https://doi.org/10.1172/JCI106085.
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A lipoprotein characterizing obstructive jaundice. I. Method for quantitative separation and identification of lipoproteins in jaundiced subjects

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Abstract

Three immunochemically and electrophoretically distinct lipoproteins, LP-A, LP-B, and LP-X,1 were isolated from the low density lipoprotein fraction (1.006-1.063 g/ml) in plasma from patients with biliary obstruction by a separation procedure which combines ultracentrifugation, heparin precipitation, and ethanol fractionation. This method, here described, permits the quantitative determination of individual plasma lipoprotein families on the basis of their protein moieties, rather than on the basis of their lipid moieties or density.

Authors

D. Seidel, P. Alaupovic, R. H. Furman

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�ber die Bedeutung der W�rmestabilisierung einer beschleunigten Blutk�rperchensenkung in der klinischen Diagnostik
F Adlkofer, U Armbrecht, W Frg, B Abrar
Klinische Wochenschrift 1978
Serum total lipids, lipoprotein cholesterol, and apolipoprotein A in acute viral hepatitis and chronic liver disease
C Vergani, G Trovato, A Delu, M Pietrogrande, N Dioguardi
Journal of clinical pathology 1978
Lipoprotein-X levels in extrahepatic versus intrahepatic cholestasis
JB Simon, RW Poon
Gastroenterology 1978
Studien zur Charakterisierung und zum Stoffwechsel des Lipoprotein-X (LP-X), des abnormen Lipoproteins der Cholestase
D Seidel
Klinische Wochenschrift 1977
Secondary hypertriglyceridaemia in patients with parenchymal liver disease
G Klose, J Windelband, A Weizel, H Greten
European Journal of Clinical Investigation 1977
Studies on the degradation of lipoprotein-X
W Patsch, JR Patsch, F Kunz, S Sailer, H Braunsteiner
European Journal of Clinical Investigation 1977
The Lipid Bilayer Structure of the Abnormal Human Plasma Lipoprotein X. An X-Ray Small-Angle-Scattering Study
P LAGGNER, O GLATTER, K MULLER, O KRATKY, G KOSTNER, A HOLASEK
European Journal of Biochemistry 1977
Effect of lipoprotein-X on hepatic cholesterol synthesis
M Liersch, G Baggio, CC Heuck, D Seidel
Atherosclerosis 1977
Lipoprotein-X: a substrate for lecithin: cholesterol acyltransferase
JR Patsch, AK Soutar, JD Morrisett, AM Gotto, LC Smith
European Journal of Clinical Investigation 1977
Fatty acid composition of adipose tissue in patients with coronary heart disease
PD Lang, J Degott, J Vollmar
Atherosclerosis 1977
Determination of cryoglobulins as lipoprotein-autoantibody immune complexes and antigenic determinants against antilipoprotein autoantibody
H Kodama
Clinical & Experimental Immunology 1977
Tagesprofile von Plasmalipiden und Lipoproteinen bei Patienten mit endogener Hypertriglyzerid�mie (Typ IV-Hyperlipoprotein�mie)
G Schlierf, P Oster, D Seidel, H Raetzer, B Schellenberg, CC Heuck, RL Wicklein
Klinische Wochenschrift 1977
Measurement of the apoproteins of human serum lipoproteins by rocket immunoelectrophoresis
AC Onitiri, B Lewis
Clinica Chimica Acta 1977
The effect of hepatitis B on plasma cholesterol and sterol balance
CD Saudek
The American Journal of Medicine 1977
Plasma lipoprotein changes in experimental cholestasis in the dog
B Danielsson, R Ekman, BG Johansson, BG Petersson
Clinica Chimica Acta 1977
Isolation and characterization of lipoprotein-x from the pig
P Müller, G Baggio, HO Barth, H Wieland, M Anari, D Seidel
Clinica Chimica Acta 1977
The structure and morphology of the abnormal serum lipoprotein-X
H Hauser, G Kostner, M Müller, P Skrabal
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1977
Characterization of high density lipoproteins in human cholestasis
B Arnesjö, B Danielsson, R Ekman, BG Johansson, BG Petersson
Scandinavian Journal of Clinical & Laboratory Investigation 1977
Characterization of baboon plasma high-density lipoproteins and of their major apoproteins
V Blaton, R Vercaemst, M Rosseneu, J Mortelmans, RL Jackson, AM Gotto, H Peeters
Biochemistry 1977
Lipid Metabolism in Mammals
F Snyder
1977
Isolation, chemical characterization, and biophysical properties of three different abnormal lipoproteins: LP-X1, LP-X2, and LP-X3
JR Patsch, KC Aune, AM Gotto, JD Morrisett
The Journal of biological chemistry 1977
Alterations of rat serum lipoproteins and lecithin-cholesterol-acyltransferase activity in praseodymium-induced liver damage
O Grajewski, BV Lehmann, HR Arntz, P Arvela, E Oberdisse
Naunyn-Schmiedeberg's Archives of Pharmacology 1977
Formation of lipoprotein-X. Its relationship to bile compounds
E Manzato, R Fellin, G Baggio, S Walch, W Neubeck, D Seidel
Journal of Clinical Investigation 1976
Effect of bile salts on the hepatic regulation of serum lecithin: cholesterol acyltransferase activity
KJ Ho, R Cisternas, GS Boyd
Atherosclerosis 1976
The fusion of abnormal plasma lipoprotein (LP-X) and the erythrocyte membrane in patients with cholestasis studied by electronmicroscopy
AJ Verkleij, IL Nauta, JM Werre, JG Mandersloot, B Reinders, PH Ververgaert, J Gier
Biochimica et Biophysica Acta (BBA) - Biomembranes 1976
Cholestatic Jaundice in Infancy Diagnosis, Differential Diagnosis and Treatment
JR Poley, HN Magnani
Journal of Paediatrics and Child Health 1976
Electron Microscopic Characterization of Lipoproteins from Patients with Familial Type III Hyperlipoproteinaemia
JR Patsch, S Sailer, H Braunsteiner, T Forte
European Journal of Clinical Investigation 1976
Investigation of the abnormal low-density lipoproteins occurring in patients with obstructive jaundice
GM Kostner, P Laggner, HJ Prexl, A Holasek
Biochemical Journal 1976
Serum alkaline phosphatase, nucleotide pyrophosphatase, 5'-nucleotidase and lipoprotein-X in cholestasis
D Brocklehurst, GH Lathe, SR Aparicio
Clinica Chimica Acta 1976
Assay of an activator for lipoprotein lipase
P Chu, AL Miller, GL Mills
Clinica Chimica Acta 1976
On the metabolism of lipoprotein-X (LP-X)
D Seidel, HU Büff, U Fauser, U Bleyl
Clinica Chimica Acta 1976
Isolation and partial characterization of two abnormal human plasma lipoproteins: LP-X1 and LP-X2
JR Patsch, W Patsch, S Sailer, H Braun-Steiner
Biochimica et Biophysica Acta (BBA) - Protein Structure 1976
Abnormal low density plasma lipoproteins occurring in dogs with obstructive jaundice
B Danielsson, R Ekman, BG Johansson, BG Petersson
FEBS Letters 1976
The influence of LP-X and other lipoproteins associated with hepatic dysfunction on the activity of lecithin :Cholesterol acyltransferase
HN Magnani
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1976
Studies on an Additional Pre-β-Lipoprotein, Sinking Pre-β (SPB)
M Källberg, L Lindén, A Gustafson
Scandinavian Journal of Clinical & Laboratory Investigation 1976
Fettstoffwechsel
G Assmann, J Augustin, E Baraona, HU Benz, W Brech, WV Brown, RJ Desnick, WR Fallat, S Ford, D Fredrickson, CJ Glueck, H Greten, K Harzer, P Herbert, GM Kostner, W Krivit, RI Levy, CS Lieber, M Liersch, G Middelhoff, GL Mills, NB Myant, RF ODea, J Papenberg, H Pilz, HM Rauen, S Sailer, G Schettler, G Schlierf, H Schriewer, D Seidel, J Slack, E Stange, O Stein, Y Stein, D Steinberg, A Weizel, H Wieland
1976
The Hepatobiliary System
W Taylor
1976
Utilization of the Quantitative Assay of Lipoprotein X in the Differential Diagnosis of Extrahepatic Obstructive Jaundice and Intrahepatic Diseases
HN Magnani, P Alaupovic
Gastroenterology 1976
Plasma Cholesterol Esterification in Liver Disease
JP Blomhoff
Scandinavian Journal of Gastroenterology 1976
Immunochemical Studies of Lipoproteins in Cholestasis
R Ekman, BG Johansson, BG Petersson
Scandinavian Journal of Immunology 1975
Lymphocyte E rosette inhibitory factor: a regulatory serum lipoprotein
FV Chisari, TS Edgington
Journal of Experimental Medicine 1975
Plasma lipoproteins in rats with experimental biliary obstruction, I. A chemical study
S Calandra, M Montaguti, V Cartoni, I Pasquali-Ronchetti
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1975
The separation and characterization of liver plasma membrane fragments circulating in the blood of patients with cholestasis
ME Broe, M Borgers, RJ Wieme
Clinica Chimica Acta 1975
The Hyperlipoproteinemias in Adolescence
S Margolis
Medical Clinics of North America 1975
Clinical and Physiological Abnormalities in Hepatic Function
RJ Grand, MH Ulshen
Pediatric Clinics of North America 1975
The hypercholesterolaemia of obstructive jaundice
N McIntyre, DS Harry, AJ Pearson
Gut 1975
Hypolipidemic Agents
D Kritchevsky
1975
Quantitative Determination of the Abnormal Lipoprotein of Cholestasis, LP-X, in Liver Disease
S Ritland
Scandinavian Journal of Gastroenterology 1975
The Abnormal ‘Lipoprotein of Cholestasis’, Lipoprotein-X
S Ritland
Scandinavian Journal of Gastroenterology 1975
Lipoproteins in lecithin-cholesterol-acyltransferase (LCAT)*-deficiency: II. Further studies on the abnormal high-density-lipoproteins
G Utermann, HJ Menzel, KH Langer, P Dieker
Human Genetics 1975
Serumlipoproteine bei akuter Virushepatitis
M Baumgarten, M Wienbeck, A Englhardt, GA Martini
Klinische Wochenschrift 1974
Hypertriglyceridaemia Secondary to Liver Disease
P Müller, R Fellin, J Lambrecht, B Agostini, H Wieland, W Rost, D Seidel
European Journal of Clinical Investigation 1974
The effect of post-heparin lipolytic activity on plasma lipoproteins
B Agostini
Histochemistry 1974
A method for quantitative determination of the abnormal lipoprotein of cholestasis, LP-X
S Ritland
Clinica Chimica Acta 1974
Behaviour of serum lipids in children with hepatitis A
I Tamir, D Heldenberg, O Levtow, Y Burstein, S Lupo, B Werbin
Clinica Chimica Acta 1974
Lipoproteines seriques anormales dans l'hepatite virale cholostatique
J Picard, D Veissiere, F Bertrand
Clinica Chimica Acta 1974
Properties of the abnormal human plasma lipoprotein (LP-X) characteristic of cholestasis after chemical modification with succinic anhydride
A Jonas, D Seidel
Archives of Biochemistry and Biophysics 1974
On the polypeptide composition of an abnormal high density lipoprotein (LP-E) occurring in LCAT-deficient plasma
G Utermann, HJ Menzel, KH Langer
FEBS Letters 1974
Composition of very low density lipoproteins from cholesterol fed animals
CE Day, B Barker, WW Stafford
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry 1974
The Red Blood Cell
GJ Brewer
The Red Blood Cell 1974
Phospholipids in Biology and Medicine
RL Jackson, AM Gotto
New England Journal of Medicine 1974
The differential diagnosis of neonatal hepatitis and biliary atresia
DP Campbell, JR Poley, P Alaupovic, EI Smith
Journal of Pediatric Surgery 1974
Isolation and analysis of human plasma lipoproteins accumulating postprandial in an intermediate density fraction (d 1.006–1.019 g/ml)
R Fellin, B Agostini, W Rost, D Seidel
Clinica Chimica Acta 1974
An unusual lipid-protein complex observed in an IgG myeloma patient
S Koga, M Kozuru, C Hirayama, H Ibayashi
Clinica Chimica Acta 1974
Lecithin: Cholesterol Acyltransferase in Human Liver Disease
JB Simon
Scandinavian Journal of Clinical & Laboratory Investigation 1974
Apolipoproteins and Lipoprotein Families in Familial Lecithin: Cholesterol Acyltransferase Deficiency
P Alaupovic, WJ McConathy, MD Curry, HN Magnani, H Torsvik, K Berg, E Gjone
Scandinavian Journal of Clinical & Laboratory Investigation 1974
Untersuchungen zum Stoffwechsel menschlicher Chylomikronen
H Greten
Klinische Wochenschrift 1974
The effect of post-heparin lipolytic activity on plasma lipoproteins: A study by electron microscopy
B Agostini
Histochemistry 1974
Department of Medicine, University of Innsbruck, Austria
F Sandhofer, K Bolzano, S Sailer, H Braansteiner
European Journal of Clinical Investigation 1973
AUSTRALIA ANTIGEN IN URINE
G Scalise, MS Mura
The Lancet 1973
HEPATITIS-B ANTIGEN: IMMUNOLOGICAL RELATIONSHIP TO LP-X, THE ABNORMAL PLASMA-LIPOPROTEIN OF OBSTRUCTIVE JAUNDICE
AR Neurath, AM Prince, A Lippin, M Chen
The Lancet 1973
Untersuchungen zur Methodik der immunologischen Lipoprotein-X (LP-X)-Bestimmung
W Petek, G Kostner, A Holasek
Clinical Chemistry and Laboratory Medicine 1973
STUDIES OF LIPOPROTEIN-X (LP-X) AND BILE ACIDS IN FAMILIAL LCAT DEFICIENCY
E Gjone, NB Javitt, JP Blomhoff, O Fausa
Acta Medica Scandinavica 1973
Secondary hyperlipidaemia
A Chait
Journal of clinical pathology. Supplement (Association of Clinical Pathologists) 1973
Study of the abnormal lipoprotein-X in obstructive and non-obstructive jaundice
C Vergani, M Pietrogrande, MC Grondona
Clinica Chimica Acta 1973
Electrophoretic Characterization of Bovine Serum Lipoproteins Throughout Gestation and Lactation
BC Raphael, PS Dimick, DL Puppione
Journal of Dairy Science 1973
Diagnosis and management of hyperlipoproteinemia in infants and children
RI Levy, BM Rifkind
The American Journal of Cardiology 1973
Effect of phenobarbital on hyperlipemia in patients with intrahepatic and extrahepatic cholestasis
WL Nyhan, LG Linarelli, FH Hengstenberg, AL Drash
The Journal of Pediatrics 1973
The distribution and composition of serum lipoproteins in the coelacanth (Latimeria)
GL Mills, CE Taylaur
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry 1973
Isolation and characterization of lipoprotein-X (LP-X) from canine
P Müller, U Fauser, R Fellin, H Wieland, D Seidel
FEBS Letters 1973
Does lipoprotein-X (LP-X) act as a substrate for the lecithin: Cholesterol acyltransferase (LCAT)?
H Wengeler, D Seidel
Clinica Chimica Acta 1973
Separation of lipoprotein X and β-lipoprotein by zonal centrifugation or hydroxyapatite chromatography
B Danielsson, BG Johansson, BG Petersson
Clinica Chimica Acta 1973
Newer diagnostic procedures in pancreatobiliary surgery
F Nakayama
The Japanese Journal of Surgery 1972
Identification of the abnormal cholestatic lipoprotein (LP-X) in familial lecithin:Cholesterol acyltransferase deficiency
H Torsvik, K Berg, HN Magnani, WJ McConathy, P Alaupovic, E Gjone
FEBS Letters 1972
Serum Cholesterol Esterification in Liver Disease. Combined Determinations of Lecithin: Cholesterol Acyltransferase and Lipoprotein-X
H Wengeler, H Greten, D Seidel
European Journal of Clinical Investigation 1972
Composition and Variation of the Gel Electrophoretic Fractions of Plasma, Cerebrospinal Fluid and Urine
CB Laurell
Scandinavian Journal of Clinical & Laboratory Investigation 1972
A method for the quantitative determination of the abnormal lipoprotein (LP-X) of obstructive jaundice
HN Magnani, P Alaupović
Clinica Chimica Acta 1972
Further Aspects on the Characterization of High and Very Low Density Lipoproteins in Patients with Liver Disease
D Seidel, H Greten, HP Geisen, H Wengeler, H Wieland
European Journal of Clinical Investigation 1972
Studies on the protein moiety of serum high density lipoprotein from patients with familial lecithin: cholesterol acyltransferase deficiency
H Torsvik
Clinical Genetics 1972
Plasmaphoresis and plasma exchange in the treatment of hyperlipaemia and xanthomatous neuropathy in patients with primary biliary cirrhosis
LA Turnberg, MP Mahoney, MH Gleeson, CB Freeman, AH Gowenlock
Gut 1972
Variation in composition of serum low density lipoproteins in healthy men
GL Mills, YH Chong, CE Taylaur
Clinica Chimica Acta 1972
Variations in the Electrophoretic Distribution of Low Density Lipoproteins of Holstein Cows
DL Puppione, B Raphael, RD McCarthy, PS Dimick
Journal of Dairy Science 1972
Studies on the composition and structure of plasma lipoproteins
P Alaupovic, DM Lee, WJ McConathy
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1972
Structure of an abnormal plasma lipoprotein (LP-X) characterizing obstructive jaundice
D Seidel, B Agostini, P Müller
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1972
Serum lipoproteins of the pacific sardine (Sardinops caerulea girard)
RF Lee, DL Puppione
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1972
Hemolysis and Changes in Erythrocyte Membrane Lipids
SB Shohet
New England Journal of Medicine 1972
Lipoprotein X simulating paraproteinemia in paper electrophoresis
P May, RK Donabedian
Clinica Chimica Acta 1972
Lipoprotein-X and the double 131I-rose bengal test in the diagnosis of prolonged infantile jaundice
JR Poley, EI Smith, DJ Boon, M Bhatia, CW Smith, JB Thompson
Journal of Pediatric Surgery 1972
Identification de l'apoeipoprotéine des lipoprotéines sériques anormales de la cholostase
J Picard, D Veissiere, F Voyer
Clinica Chimica Acta 1972
Interpretation of Hyperlipidemias
WR Harlan, WA Shaw
Critical Reviews in Clinical Laboratory Sciences 1972
Isoelektrische Fokussierung und anschlie�ende immunochemische Charakterisierung der Lipoproteine des Humanserums
G Kostner, A Depisch, W Albert, A Holasek
Monatshefte f�r Chemie Chemical Monthly 1972
Lipoproteins in LCAT-deficiency
G Utermann, W Schoenborn, KH Langer, P Dieker
Human Genetics 1972
Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: physical and chemical studies of low and high density lipoproteins
KR Norum, JA Glomset, AV Nichols, T Forte
Journal of Clinical Investigation 1971
SERUM LIPOPROTEINS IN INFANTS WITH LIVER DISEASE
RF Leonard, JM Court, DM Danks
Journal of Paediatrics and Child Health 1971
Apoliproproteins and lipoproteins
P Alaupovic
Atherosclerosis 1971
Absorption of vitamin E in children with biliary obstruction
JT Harries, DP Muller
Gut 1971
A new immunochemical technique for a rapid, semi-quantitative determination of the abnormal lipoprotein (LP-X) characterizing cholestasis
D Seidel
Clinica Chimica Acta 1971
Identification of the protein moiety of the LP(a)-lipoprotein in human plasma
D Seidel, HP Geisen, D Roelcke
FEBS Letters 1971
The Abnormal Lipoprotein of Cholestasis
RJ Havel
New England Journal of Medicine 1971
Isolation of apolipoprotein-free lipoprotein lipase from human post-heparin plasma
D Ganesan, RH Bradford
Biochemical and Biophysical Research Communications 1971
Serum phospholipids in diabetic patients with late manifestations
E Walaas, L Wille, HN Haugen
Diabetologia 1971
Cholestasis: Lamellar Structure of the Abnormal Human Serum Lipoprotein
RL Hamilton, RJ Havel, JP Kane, AE Blaurock, T Sata
Science 1971
A lipoprotein characterizing obstructive jaundice. II. Isolation and partial characterization of the protein moieties of low density lipoproteins
D Seidel, P Alaupovic, RH Furman, WJ McConathy
Journal of Clinical Investigation 1970
XANTHOMATOSIS ASSOCIATED WITH HYPERLIPOPROTEINEMIA
F Parker, JM Short
Journal of Investigative Dermatology 1970
Abnormal serum lipoprotein in cholestasis: identifcation and isolation
J Picard, D Veissiere
Clinica Chimica Acta 1970
Hyperlipoproteinämie—typ III eine möglichkeit zur immunologischen diagnostik
D Seidel, H Greten
Clinica Chimica Acta 1970
A lipoprotein characterizing obstructive jaundice: isolation and analysis
RH Furman, D Seidel, P Alaupovic
Transactions of the American Clinical and Climatological Association 1970
Occurrence of an abnormal lipoprotein in patients with liver disease
A Ross, GM Murphy, PA Wilkinson, GL Mills, S Sherlock
Gut 1970
Classification of hyperlipidaemias and hyperlipoproteinaemias
JL Beaumont, LA Carlson, GR Cooper, Z Fejfar, DS Fredrickson, T Strasser
Bulletin of the World Health Organization 1970
Serum Cholesterol Esterification in Liver Disease: Importance of Lecithin-Cholesterol Acyltransferase
JB Simon, R Scheig
New England Journal of Medicine 1970
Composition and structure of plasma lipoproteins. Isolation, composition, and immunochemical characterization of low density lipoprotein subfractions of human plasma
DM Lee, P Alaupovic
Biochemistry 1970
Fortschritte in der Analyse der Plasmalipoproteine: Eine neue M�glichkeit zur Differentialdiagnose des Ikterus
D Seidel, P Alaupovic, RH Furman
Klinische Wochenschrift 1970
Ultracentrifugal characterization of a lipoprotein occurring in obstructive jaundice
GL Mills, D Seidel, P Alaupovic
Clinica Chimica Acta 1969
Identification of the protein moiety of an abnormal human plasma low-density lipoprotein in obstructive jaundice
P Alaupovic, D Seidel, WJ McConathy, RH Furman
FEBS Letters 1969
Protides of the Biological Fluids
PA Small, RH Waldman
Protides of the Biological Fluids 1969
Standard Methods of Clinical Chemistry
M Reiner, HL Cheung, SM Kennedy, S.s.j., O Ekimoff, SM Sax, RE Vanderlinde, J Mccreary
Standard Methods of Clinical Chemistry 1965
Advances in Lipid Research
AM Scanu
Advances in Lipid Research 1965
Jaundice
S Sherlock
British medical journal 1962
The Plasma Proteins
ML Petermann
The Plasma Proteins 1960

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