Differentiation of glomerular, tubular, and normal proteinuria: determinations of urinary excretion of β₂-microglobulin, albumin, and total protein

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Abstract

A low molecular weight β2-globulin (β2-microglobulin), albumin, and total protein were measured in concentrated 24-hr urine specimens from 20 healthy subjects and 30 patients with clinical proteinuria of glomerular or tubular type. Classification of proteinuria was made on the basis of clinical diagnosis and size distribution of urinary proteins after gel chromatography. The molecular radii (Stokes' radii) of β2-microglobulin and albumin, estimated by gel chromatography, were 15 A and 35 A.

Authors

Per A. Peterson, Per-Eric Evrin, Ingemar Berggård