Studies on the control of sodium excretion in experimental uremia

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Abstract

A study of the mechanisms governing the high rate of sodium excretion per nephron characteristic of patients with chronic renal disease has been made in dogs. A “remnant kidney” was produced by 85% infarction of the left kidney while the right kidney was left intact. A bladder-splitting procedure allowed simultaneous measurement of glomerular filtration rate and the rate of sodium excretion by each kidney. The animals were fed a constant known amount of sodium chloride and 0.1 mg of 9 α-fluorohydrocortisone twice daily throughout the study.

Authors

Raymond G. Schultze, Howard S. Shapiro, Neal S. Bricker