Citations to this article

Deficient activity of dephosphophosphorylase kinase and accumulation of glycogen in the liver
George Hug, … , William K. Schubert, Gail Chuck
George Hug, … , William K. Schubert, Gail Chuck
Published April 1, 1969
Citation Information: J Clin Invest. 1969;48(4):704-715. https://doi.org/10.1172/JCI106028.
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Research Article

Deficient activity of dephosphophosphorylase kinase and accumulation of glycogen in the liver

Abstract

Low activity of phosphorylase and increased concentration of glycogen were found in liver tissue from five children with asymptomatic hepatomegaly. In vitro activation of liver phosphorylase in these patients occurred at the rate of 10% or less of normal. Elimination of the defect by the addition of kinase that activates phosphorylase demonstrated the integrity of the phosphorylase enzyme and the deficient activity of dephophophosphorylase kinase.

Authors

George Hug, William K. Schubert, Gail Chuck

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Citations to this article (55)

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