Plasma from persons with hereditary angioneurotic edema readily developed the capacity to increase vascular permeability and to induce the isolated rat uterus to contract. Both activities resided in a small, heat-stable molecule that was apparently a polypeptide. Crude preparations of the polypeptide were inactivated during incubation with trypsin. They also failed to produce pain and erythema, but caused markedly increased vascular permeability in human skin. These characteristics differ from those of bradykinin, from which crude preparations of the polypeptide could also be distinguished by electrophoretic mobility and paper chromatographic behavior. Proof that the polypeptide is truly different from bradykinin must await its further purification. Histamine played no role in the activities observed.
Virginia H. Donaldson, Oscar D. Ratnoff, Wilmar Dias Da Silva, Fred S. Rosen
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Title and authors | Publication | Year |
---|---|---|
The central role of endothelium in hereditary angioedema due to C1 inhibitor deficiency
MA Wu, M Bova, S Berra, R Senter, D Parolin, S Caccia, M Cicardi |
International Immunopharmacology | 2020 |
Hereditary Angioedema with Normal C1 Inhibitor
M Magerl, AE Germenis, C Maas, M Maurer |
Immunology and Allergy Clinics of North America | 2017 |
The Clinical Chemistry of Laboratory Animals
DM Kurtz, GS Travlos |
The Clinical Chemistry of Laboratory Animals | 2017 |
The Story of Angioedema: from Quincke to Bradykinin
A Reshef, M Kidon, I Leibovich |
Clinical Reviews in Allergy & Immunology | 2016 |
Contact System Activation in Patients with HAE and Normal C1 Inhibitor Function
A Ghannam, F Defendi, D Charignon, F Csopaki, B Favier, M Habib, S Cichon, C Drouet |
Immunology and Allergy Clinics of North America | 2013 |
The New Era of C1-Esterase Inhibitor Deficiency Therapy
LM Tourangeau, BL Zuraw |
Current Allergy and Asthma Reports | 2011 |
Pathophysiology of Hereditary Angioedema
BL Zuraw, SC Christiansen |
American journal of rhinology & allergy | 2011 |
Advances in Immunology
E Pinaud, M Marquet, R Fiancette, S Péron, C Vincent-Fabert, Y Denizot, M Cogné |
Advances in Immunology Volume 110 | 2011 |
The Pathophysiology of Hereditary Angioedema
BL Zuraw |
World Allergy Organization Journal | 2010 |
HAE therapies: past present and future
BL Zuraw |
Allergy Asthma & Clinical Immunology | 2010 |
The Pathophysiology of Hereditary Angioedema
BL Zuraw |
World Allergy Organization Journal | 2010 |
C1-inhibitor deficiency and angioedema: molecular mechanisms and clinical progress
M Cugno, A Zanichelli, F Foieni, S Caccia, M Cicardi |
Trends in Molecular Medicine | 2009 |
Novartis Foundation Symposia
EJ Campbell |
Ciba Foundation Symposium 44 - Research and Medical Practice: Their Interaction | 2008 |
Hereditary angioedema: a current state-of-the-art review, III: mechanisms of hereditary angioedema
AE Davis |
Annals of Allergy Asthma & Immunology | 2008 |
Hereditary angioedema: a current state-of-the-art review, II: historical perspective ofnon-histamine-induced angioedema
IL Bernstein |
Annals of Allergy Asthma & Immunology | 2008 |
New treatments addressing the pathophysiology of hereditary angioedema
AE Davis |
Clinical and Molecular Allergy | 2008 |
The deficiency of C1 inhibitor and its treatment
M Cicardi, LC Zingale |
Immunobiology | 2007 |
Novel Therapies for Hereditary Angioedema
BL Zuraw |
Immunology and Allergy Clinics of North America | 2006 |
C1 inhibitor: molecular and clinical aspects
M Cicardi, L Zingale, A Zanichelli, E Pappalardo, B Cicardi |
Springer Seminars in Immunopathology | 2005 |
The pathophysiology of hereditary angioedema
AE Davis |
Clinical Immunology | 2005 |
Deficiencies of C1 inhibitor
FS Rosen, AE Davis |
Best Practice & Research Clinical Gastroenterology | 2005 |
The pathogenesis of hereditary angioedema
AE Davis |
Transfusion and Apheresis Science | 2003 |
DX-88 and HAE: a developmental perspective
A Williams, LG Baird |
Transfusion and Apheresis Science | 2003 |
Inflammation
JA Hunt |
Encyclopedia of Materials Science and Technology | 2001 |
Sonographic findings in abdominal hereditary angioedema
S Sofia, A Casali, L Bolondi |
Journal of Clinical Ultrasound | 1999 |
The Human Complement System in Health and Disease
J Ahearn, A Rosengard |
The Human Complement System in Health and Disease | 1998 |
ACE Inhibitor???Induced Angioedema: Incidence, Prevention and Management
W Vleeming, JG van Amsterdam, BH Ch., DJ de Wildt |
Drug Safety | 1998 |
The Kinin System
A Schmaier |
The Kinin System | 1997 |
Activation of the Coagulation Cascade in C1-Inhibitor Deficiencies
M Cugno, M Cicardi, B Bottasso, R Coppola, R Paonessa, PM Mannucci, A Agostoni |
Blood | 1997 |
Hereditary angioneurotic oedema: characterization of plasma kinin and vascular permeability-enhancing activities
LR Shoemaker, SJ Schurman, VH Donaldson, AE Davis |
Clinical & Experimental Immunology | 1994 |
Hereditary angioneurotic oedema: characterization of plasma kinin and vascular permeability-enhancing activities.
Shoemaker LR, Schurman SJ, Donaldson VH, Davis AE 3rd |
Clinical & Experimental Immunology | 1994 |
C1-Inhibitor and Its Genetic Alterations in Hereditary Angioneurotic Edema
VH Donaldson |
International Reviews of Immunology | 1993 |
IgA nephropathy in hereditary angioedema
J Srinivasan, P Beck |
Postgraduate medical journal | 1993 |
Hereditary angioedema: Its diagnostic and management perspectives
TC Sim, JA Grant |
The American Journal of Medicine | 1990 |
Advances in Human Genetics
H Harris, K Hirschhorn |
1990 | |
Long-term prophylaxis with C1-inhibitor (C1 INH) concentrate in patients with recurrent angioedema caused by hereditary and acquired C1-inhibitor deficiency
K Bork, G Witzke |
Journal of Allergy and Clinical Immunology | 1989 |
Pathways of kinin formation and role in allergic diseases
AP Kaplan, M Silverberg, B Ghebrehiwet, P Atkins, B Zweiman |
Clinical Immunology and Immunopathology | 1989 |
Kinins V
K Abe, H Moriya, S Fujii |
1989 | |
Pharmacology of the Skin II
MW Greaves, S Shuster |
1989 | |
Urine-histamine levels in patients with hereditary angioedema (HAE)
CM Brickman, MM Frank, M Kaliner |
Journal of Allergy and Clinical Immunology | 1988 |
Angioedema induced by a peptide derived from complement component C2
CJ Strang, S Cholin, J Spragg, AE 3rd, EE Schneeberger, VH Donaldson, FS Rosen |
Journal of Experimental Medicine | 1988 |
Complement in the Pathophysiology of Human Disease
MM Frank |
New England Journal of Medicine | 1987 |
Demonstration of modified inactive first component of complement (C1) inhibitor in the plasmas of C1 inhibitor-deficient patients
BL Zuraw, JG Curd |
Journal of Clinical Investigation | 1986 |
The contact activation system: Biochemistry and interactions of these surface-mediated defense reactions
RW Colman, AH Schmaier, OD Ratnoff |
Critical Reviews in Oncology/Hematology | 1986 |
Complement profile in a Cr inhibitor deficient family
K Sayama, S Shiraishi, Y Miki |
British Journal of Dermatology | 1985 |
Cleavage of the second component of complement by plasma proteases: implications in hereditary C1-inhibitor deficiency
MA Smith, MA Kerr |
Immunology | 1985 |
Generation of the bioactive kallikrein-derived fragment, C3d-k, by HANE-plasma
T Seya, S Nagasawa, JP Atkinson |
Clinical & Experimental Immunology | 1985 |
Acquired C1-Inhibitor Deficiency Associated with Antiidiotypic Antibody to Monoclonal Immunoglobulins
RS Geha, I Quinti, KF Austen, M Cicardi, A Sheffer, FS Rosen |
New England Journal of Medicine | 1985 |
Effcts of Dextran Sulphate (Dxs) on Lymphocyte Localization in Complement-Deficient Mice: Evidence that the Fifth Component of Complement is not Implicated in the Dxs Activity
A Bellavia, PD Fiore |
Immunopharmacology and Immunotoxicology | 1984 |
In vitro alternative and classical activation of complement by extracts of cotton mill dust: A possible mechanism in the pathogenesis of byssinosis
TG Mundie, RJ Boackle, SK Ainsworth |
Environmental Research | 1983 |
Inherited disorders of complement
LC Guenther |
Journal of the American Academy of Dermatology | 1983 |
The Challenge of Hereditary Angioneurotic Edema
VH Donaldson |
New England Journal of Medicine | 1983 |
Immunopathology
NR Rose, BV Siegel |
1983 | |
Microcirculation of the alimentary tract
DN Granger, JA Barrowman |
Gastroenterology | 1983 |
An association between C1 esterase inhibitor deficiency and lupus erythematosus: Report of two cases and review of the literature
MC Massa, SM Connolly |
Journal of the American Academy of Dermatology | 1982 |
The pathogenic basis of urticaria and angioedema: Recent advances
AP Kaplan |
The American Journal of Medicine | 1981 |
Current Topics in Cellular Regulation
G Cahill, T Aoki, R Smith |
Current Topics in Cellular Regulation | 1981 |
New Trends in Allergy
J Ring, G Burg |
1981 | |
Detection of active kallikrein in induced blister fluids of hereditary angioedema patients
JG Curd, LJ Prograis, CG Cochrane |
Journal of Experimental Medicine | 1980 |
Effects of dextran sulphate and heparin on lymphocyte localization: Lack of involvement of complement and other plasma proteolytic systems
A Bellavia, V Franklin, HS Micklem |
International Journal of Immunopharmacology | 1980 |
Response of Variant Hereditary Angioedema Phenotypes to Danazol Therapy GENETIC IMPLICATIONS
JE Gadek, SW Hosea, JA Gelfand, MM Frank |
Journal of Clinical Investigation | 1979 |
The Antigens
PJ Lachmann |
The Antigens | 1979 |
Birth Defects Compendium
D Bergsma |
Birth Defects Compendium | 1979 |
Inflammatory Reaction
HZ Movat |
1979 | |
Immunochemistry of Proteins
MZ Atassi |
1979 | |
Genetic defects of complement in man
PJ Lachmann, FS Rosen |
Springer Seminars in Immunopathology | 1978 |
Hereditary angio-oedema in relation to dentistry
JE Hurley, MR Rayden |
British Journal of Oral Surgery | 1978 |
Complement: A host defense mechanism ready for pharmacological manipulation?
BJ Johnson |
Journal of Pharmaceutical Sciences | 1977 |
Hereditary Angioneurotic Oedema in Finland
K Ohela |
Acta Medica Scandinavica | 1977 |
INHERITED DEFICIENCIES OF COMPLEMENT IN MAN
TL Ray, KD Wuepper |
International Journal of Dermatology | 1977 |
Acute inflammation. A review
GB Ryan, G Majno |
The American Journal of Pathology | 1977 |
Hereditary angioedema: review of literature and dental treatment
MW Heft, PM Flynn |
The Journal of the American Dental Association | 1977 |
Frontiers of Medicine
GM Meade |
Frontiers of Medicine | 1977 |
Biological Amplification Systems in Immunology
NK Day, RA Good |
1977 | |
Inflammation: Mechanisms and their Impact on Therapy
IL Bonta, J Thompson, K Brune |
1977 | |
Mediators of inflammation
OD Ratnoff |
Journal of Allergy and Clinical Immunology | 1976 |
In vitro activation of C1s in plasma of patients with hereditary angioneurotic oedema
S Shafiasghar, RH Cormane, KW Pondman |
Clinical & Experimental Immunology | 1976 |
Antithrombin-heparin cofactor: An inhibitor of plasma kallikrein
B Lahiri, A Bagdasarian, B Mitchell, RC Talamo, RW Colman, RD Rosenberg |
Archives of Biochemistry and Biophysics | 1976 |
Inhibition of the enzymatic activity of the first component of complement (C1) by heparin
R Strunk, HR Colten |
Clinical Immunology and Immunopathology | 1976 |
Complement and the Clinician
DG Palmer |
Australian and New Zealand Journal of Medicine | 1976 |
Allergic Diseases of the Skin
E Rajka, S Korossy |
1976 | |
The human complement system
JE Volanakis |
Journal of Oral Pathology and Medicine | 1975 |
Hereditary angioedema: The use of fresh frozen plasma for prophylaxis in patients undergoing oral surgery
CJ Jaffe, JP Atkinson, JA Gelfand, MM Frank |
Journal of Allergy and Clinical Immunology | 1975 |
Observations on the ultrastructure of lesions induced in human and guinea pig skin by C 1 esterase and polypeptide from hereditary angioneurotic edema (HANE) plasma
K Willms, FS Rosen, VH Donaldson |
Clinical Immunology and Immunopathology | 1975 |
Complement inclinical medicine
MM Frank, JP Atkinson |
Disease-a-Month | 1975 |
Complement in Lupus
PH Schur |
Clinics in rheumatic diseases | 1975 |
Interactions of C-reactive protein with the complement system. I. Protamine-induced consumption of complement in acute phase sera
J Siegel, R Rent, H Gewurz |
Journal of Experimental Medicine | 1974 |
Proteinase Inhibitors
H Fritz, H Tschesche, LJ Greene, E Truscheit |
1974 | |
Mediators of Inflammation
G Weissmann |
Mediators of Inflammation | 1974 |
Komplement
K Rother |
1974 | |
HEREDITARY ANGIOEDEMA
I Gigli |
Journal of Investigative Dermatology | 1973 |
Inhibition of Carrageenin-Induced Rat Paw Oedema by Catecholamines and Amine-Depleting Drugs
FC Arntzen, K Briseid |
Acta Pharmacologica et Toxicologica | 1973 |
Hereditary angioneurotic edema
PS Kennedy, RK Goyal, T Hersh |
The American Journal of Digestive Diseases | 1972 |
TREATMENT OF HEREDITARY ANGIONEUROTIC OEDEMA WITH TRANEXAMIC ACID
G Blohmé |
Acta Medica Scandinavica | 1972 |
Specificity of inhibitors lacking in alpha1 antitrypsin deficiency and hereditary angioedema toward human proteolytic enzymes
RW Colman, B Mitchell |
Clinica Chimica Acta | 1972 |
Chemical Mediators of the Vascular Phenomena of the Acute Inflammatory Reaction and of Immediate Hypersensitivity
HZ Movat |
Medical Clinics of North America | 1972 |
Vasopeptides
N Back, F Sicuteri |
1972 | |
HEREDITARY ANGIONEUROTIC OEDEMA IN THREE FAMILIES: Symptomatic Heterogeneity, Complement Analysis and Therapeutic Trials
G Blohmé, L Ysander, K KorsanBengtsen, AB Laurell |
Journal of Internal Medicine | 1972 |
Hereditary angioneurotic edema: A case with recurring abdominal pain
PS Kennedy, RK Goyal, T Hersh |
The American Journal of Digestive Diseases | 1972 |
C1r, subunit of the first complement component: purification, properties, and assay based on its linking role
MM de Bracco, RM Stroud |
Journal of Clinical Investigation | 1971 |
Hereditary angio-oedema: a review with particular reference to pathogenesis and treatment
K Hadjiyannaki, PJ Lachmann |
Clinical & Experimental Allergy | 1971 |
Histopathological and ultrastructural observations on tissues from patients with hereditary angioneurotic edema
AL Sheffer, JM Craig, K Willms-Kretschmer, KF Austen, FS Rosen |
Journal of Allergy and Clinical Immunology | 1971 |
Les antiprotéases du plasma
M Steinbuch |
Revue Française de Transfusion | 1971 |
Progress in Immunology
IH Lepow |
Progress in Immunology | 1971 |
Immunologic studies on aspirin
AM Yurchak, K Wicher, CE Arbesman |
Journal of allergy | 1970 |
Hereditary angioneurotic oedema: an unusual case of recurring abdominal pain
EJ Feller, HM Spiro, LA Katz |
Gut | 1970 |
The Neurotic Edema (Hereditary Angioedema)
FS Rosen, KF Austen |
New England Journal of Medicine | 1969 |
Immunopharmacology
BB Levine |
Immunopharmacology | 1968 |