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Citations to this article

Permeability-increasing activity in hereditary angioneurotic edema plasma: II. Mechanism of formation and partial characterization
Virginia H. Donaldson, … , Wilmar Dias Da Silva, Fred S. Rosen
Virginia H. Donaldson, … , Wilmar Dias Da Silva, Fred S. Rosen
Published April 1, 1969
Citation Information: J Clin Invest. 1969;48(4):642-653. https://doi.org/10.1172/JCI106022.
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Permeability-increasing activity in hereditary angioneurotic edema plasma: II. Mechanism of formation and partial characterization

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Abstract

Plasma from persons with hereditary angioneurotic edema readily developed the capacity to increase vascular permeability and to induce the isolated rat uterus to contract. Both activities resided in a small, heat-stable molecule that was apparently a polypeptide. Crude preparations of the polypeptide were inactivated during incubation with trypsin. They also failed to produce pain and erythema, but caused markedly increased vascular permeability in human skin. These characteristics differ from those of bradykinin, from which crude preparations of the polypeptide could also be distinguished by electrophoretic mobility and paper chromatographic behavior. Proof that the polypeptide is truly different from bradykinin must await its further purification. Histamine played no role in the activities observed.

Authors

Virginia H. Donaldson, Oscar D. Ratnoff, Wilmar Dias Da Silva, Fred S. Rosen

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Total citations by year

Year: 2020 2017 2016 2013 2011 2010 2009 2008 2007 2006 2005 2003 2001 1999 1998 1997 1994 1993 1990 1989 1988 1987 1986 1985 1984 1983 1982 1981 1980 1979 1978 1977 1976 1975 1974 1973 1972 1971 1970 1969 1968 Total
Citations: 1 2 1 1 3 3 1 4 1 1 3 2 1 1 2 2 2 2 2 4 2 1 2 4 1 5 1 3 2 5 2 8 6 5 4 2 7 5 2 1 1 108
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Citations to this article (108)

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