Citations to this article

Bone matrix turnover and balance in vitro: II. The effects of ageing
Barry Flanagan, George Nichols Jr.
Barry Flanagan, George Nichols Jr.
Published April 1, 1969
Citation Information: J Clin Invest. 1969;48(4):607-612. https://doi.org/10.1172/JCI106019.
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Bone matrix turnover and balance in vitro: II. The effects of ageing

Abstract

The rates of both formation and resorption of bone collagen may be accurately quantitated by kinetic analysis of hydroxyproline metabolism in vitro. Using this approach we have studied the changes in bone collagen turnover with age in the rat. The rates of synthesis and resorption of collagen decline with age although the resorptive activity per cell increases up to 6 months of age. The solubility of collagen declines with age. The fraction of the newly synthesized collagen which is deposited as matrix declines dramatically with age revealing a new and hitherto unsuspected aspect of the osteoporotic process. The collagen balance becomes progressively more negative over the 1st 6 months of life. These results indicate that even in an animal who is not subject to clinical osteoporosis, biochemical measurement reveals that such a trend exists. The application of this approach to human subjects is feasible and has important implications.

Authors

Barry Flanagan, George Nichols Jr.

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Year: 2018 2015 2012 2009 2000 1987 1978 1976 1974 1973 1972 1971 1969 Total
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Citations to this article (17)

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Osteoporosis, Calcium Requirement, and Factors Causing Calcium Loss
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Kinetic parameters of calcium metabolism and femur morphometry in rats
M Blanuša, M Bogunović, V Matković 		Pflügers Archiv European Journal of Physiology 1978
Kinetic parameters of calcium metabolism and femur morphometry in rats: I. Influence of sex and age
M Blanuša, M Bogunović, V Matković 		Pflügers Archiv - European Journal of Physiology 1978
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MM Popovtzer, M Stjernholm, WE Huffer 		The American Journal of Medicine 1976
Secretory territories and rate of matrix production of osteoblasts
SJ Jones 		Calcified Tissue Research 1974
Studies on the connective tissue of reptiles—I. Age changes in collagen and water contents of bone and hyoid cartilage of male garden lizard
GK Panigrahy, BK Patnaik 		Experimental Gerontology 1973
Effects of Long-Term Administration of Bendroflumethiazide on Bone Metabolism in the Rat
FS Jørgensen, SP Nielsen 		Acta Pharmacologica et Toxicologica 1972
Aseptic necrosis in the femur after renal transplantation
WA Briggs, CL Hampers, JP Merrill, EB Hager, RE Wilson, AG Birtch, JE Murray 		Annals of Surgery 1972
Accelerated chromatographic method for determination of hydroxyproline
PX Callahan, JA Shepard, S Ellis 		Analytical Biochemistry 1972
Structure
JJ Reynolds 		Structure 1972
Compartmental analysis of collagen synthesis in fetal rat calvaria
JM Phang, GA Finerman, B Singh, LE Rosenberg, M Berman 		Biochimica et Biophysica Acta (BBA) - General Subjects 1971
Bone Matrix Turnover And Balance In Vitro I. The effects of parathyroid hormone and thyrocalcitonin
B Flanagan, G Nichols 		Journal of Clinical Investigation 1969

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