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The enzymatic mechanisms for deoxythymidine synthesis in human leukocytes: IV. Comparisons between normal and leukemic leukocytes
Robert C. Gallo, Seymour Perry
Robert C. Gallo, Seymour Perry
Published January 1, 1969
Citation Information: J Clin Invest. 1969;48(1):105-116. https://doi.org/10.1172/JCI105958.
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The enzymatic mechanisms for deoxythymidine synthesis in human leukocytes: IV. Comparisons between normal and leukemic leukocytes

Abstract

(1) Synthesis of deoxythymidine by either direct transfer of deoxyribosyl to thymine (pyrimidine deoxyribosyltransferase) or by a coupled deoxynucleoside phosphorylase mechanism is approximately twofold greater with normal leukocyte extracts (55 to 88% granulocytes) than with extracts prepared from leukocytes obtained from patients with chronic myelogenous leukemia. Activities in lymphocytes (normal or leukemic) are one-fifth the activity of normal granulocytes.

Authors

Robert C. Gallo, Seymour Perry

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Year: 1999 1990 1988 1986 1985 1984 1983 1981 1980 1975 1974 1972 1969 1968 1960 1954 Total
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Citations to this article (23)

Title and authors Publication Year
Determination of thymidine phosphorylase activity in leukemic blast cells by a high-performance liquid-chromatographic assay
V Nuessler, A Pogrebniak, R Pelka-Fleischer, K Boos, W Wilmanns 		Chromatographia 1999
Metabolism of pyrimidine analogues and their nucleosides
GC Daher, BE Harris, RB Diasio 		Pharmacology & Therapeutics 1990
The role of blood platelets in nucleoside metabolism: assay, cellular location and significance of thymidine phosphorylase in human blood
T Shaw, RH Smillie, DG MacPhee 		Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 1988
Phosphorolysis of 5′-deoxy-5-fluorouridine in human plasma, serum and blood platelets
D Meynial, MC Malet-Martino, A Lopez, R Martino 		Journal of Pharmacy and Pharmacology 1986
Metabolic breakdown of [3H]thymidine and the inability to measure human lymphocyte proliferation by incorporation of radioactivity
J Bodycote, S Wolff 		Proceedings of the National Academy of Sciences 1986
Kinetic studies of thymidine phosphorylase from mouse liver
MH Iltzsch, MH el Kouni, S Cha 		Biochemistry 1985
Human tissues degrade uridine much less than thymidine. Possible consequence for 5-fluorouracil therapy
B Liermann, E Matthes, P Langen 		Biochemical Pharmacology 1984
Canine cyclic hematopoiesis is associated with abnormal purine and pyrimidine metabolism
WR Osborne, WP Hammond, DC Dale 		Journal of Clinical Investigation 1983
Catabolism of thymidine in human blood platelets purification and properties of thymidine phosphorylase
C Desgranges, G Razaka, M Rabaud, H Bricaud 		Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis 1981
A rapid and simple radiometric assay for thymidine phosphorylase of human peripheral blood cells
TE Gan, L Hallam, GR Pilkington, MB van der Weyden 		Clinica Chimica Acta 1981
Methotrexate-induced misincorporation of uracil into DNA
M Goulian, B Bleile, BY Tseng 		Proceedings of the National Academy of Sciences 1980
INCORPORATION OF ANALOG PURINE NUCLEOSIDES INTO THE FORMED ELEMENTS OF HUMAN BLOOD: ERYTHROCYTES, PLATELETS, AND LYMPHOCYTES
RE Parks, GW Crabtree, CM Kong, RP Agarwal, KC Agarwal, EM Scholar 		Annals of the New York Academy of Sciences 1975
Purification and Properties of Cytidine Deaminase from Normal and Leukemic Granulocytes
BA Chabner, DG Johns, CN Coleman, JC Drake, WH Evans 		Journal of Clinical Investigation 1974
Methods for the study of purine metabolism in human cells in vitro
JF Henderson, JH Fraser, EE McCoy 		Clinical Biochemistry 1974
The Molecular Biology of Cancer
E Bresnick 		The Molecular Biology of Cancer 1974
Purine Metabolism in Man
O Sperling, AD Vries, JB Wyngaarden 		1974
Enzyme des Thymidin- und Thymidylat-Stoffwechsels in normalen und pathologischen Zellen des Blutes und des Knochenmarks
S Schollenberger, D Taureck, W Wilmanns 		Blut Zeitschrift für die Gesamte Blutforschung 1972
Leukämie
R Gross, J van de Loo 		1972
Transfer RNA's in human leukemia
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Isopentenyladenosine Stimulates and Inhibits Mitosis of Human Lymphocytes Treated with Phytohemagglutinin
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Blut und Blutkrankheiten
L Heilmeyer, K Betke, KG von Boroviczény, D Busch, E Grundmann, H Heimpel, G Hoffmann, W Hunstein, W Keiderling, M Matthes, H Merker, W Müller, P Pfannenstiel 		1968
Methods of Biochemical Analysis: Glick/Methods
D Glick 		1960
Biochemistry of Human Cancer
HM Lemon, BS Walker, MM Reynolds, HH Wotiz 		New England Journal of Medicine 1954

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