Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Effect of diphenylhydantoin on synaptosome sodium-potassium-ATPase
Barry W. Festoff, Stanley H. Appel
Barry W. Festoff, Stanley H. Appel
Published December 1, 1968
Citation Information: J Clin Invest. 1968;47(12):2752-2758. https://doi.org/10.1172/JCI105956.
View: Text | PDF
Research Article

Effect of diphenylhydantoin on synaptosome sodium-potassium-ATPase

  • Text
  • PDF
Abstract

Previous studies have demonstrated that electrically induced seizures in rat result in an increased brain intracellular sodium which can be decreased by treatment with sodium diphenylhydantoin (DPH). The correlation of cation transport with membrane-oriented sodium-potassium-adenosine triphosphatase (Na-K-ATPase) prompted an investigation of the effect of DPH upon ATPase enzyme activity.

Authors

Barry W. Festoff, Stanley H. Appel

×

Total citations by year

Year: 2019 2009 1996 1994 1991 1990 1989 1988 1987 1986 1985 1983 1982 1981 1980 1979 1978 1977 1976 1975 1974 1973 1972 1971 1970 1969 1964 Total
Citations: 1 1 1 3 1 2 1 1 2 5 3 5 2 1 4 2 4 3 8 7 8 6 9 7 2 4 1 94
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (94)

Title and authors Publication Year
Allosteric Modulators of Sigma-1 Receptor: A Review
E Vavers, L Zvejniece, T Maurice, M Dambrova
Frontiers in pharmacology 2019
Medical treatment of insulinomas: The role of diphenylhydantoin
LA Nabbout, IS Salti, MT Merheb
International Journal of Diabetes Mellitus 2009
Basis of the antiseizure action of phenytoin
G Tunnicliff
General Pharmacology: The Vascular System 1996
In Vivo and In Vitro Effects of Phenytoin (PHT) on ATPases and [14C]-PHT Binding in Synaptosomes and Mitochondria from Rat Cerebral Cortex
F Vargas, P Vargas, K Aoki, D Martinez-Munoz
Epilepsia 1994
Phenytoin reduces neonatal hypoxic-ischemic brain damage in rats
T Hayakawa, Y Hamada, T Maihara, H Hattori, H Mikawa
Life Sciences 1994
Effects of the Conventional Anticonvulsants, Phenytoin, Carbamazepine, and Valproic Acid, on Sodium-Potassium-Adenosine Triphosphatase in Acute Ischemic Brain:
A Murakami, T Furui
Neurosurgery 1994
Effect of PN 200?110 on penicillin-induced epileptic activity in the rat cerebral cortex
GN Kryzhanovskii, MN Karpova, OY Pankov
Bulletin of Experimental Biology and Medicine 1991
Chronic effects of phenytoin on brain-stem auditory evoked potentials in man
YW Chan, E Woo, YL Yu
Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section 1990
Phenytoin affects metabolism of free fatty acids and nucleotides in rat cerebral ischemia
H Kinouchi, S Imaizumi, T Yoshimoto, M Motomiya
Stroke; a journal of cerebral circulation 1990
Phenytoin dephosphorylates the alpha (−) catalytic subunit of (Na+, K+)-ATPase
D Guillaume, T Grisar, AV Delgado-Escueta, A Minet, M Vergniolle-Burette, M Bureau-Heeren
Biochemical Pharmacology 1989
Mechanisms of Cerebral Hypoxia and Stroke
G Somjen
1988
Investigations into the neuropharmacological basis of temporal stages of memory formation in mice trained in an active avoidance task
SJ Mizumori, DH Sakai, MR Rosenzweig, EL Bennett, P Wittreich
Behavioural Brain Research 1987
Treatment of Cerebral Infarction
J Suzuki
1987
Phenytoin Dephosphorylates the Catalytic Subunit of the (Na+,K+)-ATPase in C57/BL Mice
D Guillaume, T Grisar, AV Delgado-Escueta
Journal of Neurochemistry 1986
The Na,K-ATPase of nervous tissue
WL Stahl
Neurochemistry International 1986
Involvement of a GABAergic mechanism in the pharmacologic action of phenytoin
AY Chweh, EA Swinyard, HH Wolf
Pharmacology Biochemistry and Behavior 1986
Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques
E Jucker
1986
Diphenylhydantoin (DPH) blocks HIV-receptor on T-lymphocyte surface
JP Zimmer, HA Lehr, ME Kornhuber, D Breitig, L Montagnier, K Gietzen
Blut Zeitschrift für die Gesamte Blutforschung 1986
Effect of phenytoin on intracellular calcium and intracellular protein changes during pentylenetetrazole-induced bursting activity in snail neurons
E Sugaya, M Onozuka, H Furuichi, K Kishii, S Imai, A Sugaya
Brain Research 1985
Modulation by ouabain and diphenylhydantoin of veratridine-induced 22Na influx and its relation to 45Ca influx and the secretion of catecholamines in cultured bovine adrenal medullary cells
A Wada, F Izumi, N Yanagihara, H Kobayashi
Naunyn-Schmiedeberg's Archives of Pharmacology 1985
Alterations of Metabolites in the Nervous System
A Lajtha
1985
Effects of sodium pentobarbitone on the bioelectric properties of isolated toad skin
B Norris, JC Saez, R Wrcka, J Concha
Neuropharmacology 1983
Phenytoin: Basic and clinical pharmacology
GL Jones, GH Wimbish, WE McIntosh
Medicinal Research Reviews 1983
Current Topics in Membranes and Transport
J Gliemann, WD Rees
Current Topics in Membranes and Transport 1983
Effect of metabolic acidosis on phosphate transport by the renal brush-border membrane
B S Levine, K Ho, J A Kraut, J W Coburn, K Kurokawa
Biochimica et Biophysica Acta 1983
Evidence against an involvement of Na+, K+-ATPase in antiarrhythmic mechanism of phenytoin
HM Rhee
Naunyn-Schmiedeberg's Archives of Pharmacology 1983
Cellular Bases of Barbiturate and Phenytoin Anticonvulsant Drug Action
RL Macdonald, MJ McLean
Epilepsia 1982
Inhibitory effect of prostaglandin A2 on Na+-K+ -ATPase activity in synaptic plasma membrane of rat brain in vitro
Y Shibata, H Ohzeki, M Sato, Y Suzuki, H Takiguchi
International Journal of Biochemistry 1982
Effect of diazepam on electrical activity and Na,K-ATP-ase level in a penicillin-induced epileptic focus in the rat cerebral cortex
MB Rekhtman, NA Samsonova, GN Kryzhanovskii
Neurophysiology 1981
Commentaries in the Neurosciences
G Burnstock
Commentaries in the Neurosciences 1980
Cerebral protective, metabolic, and vascular effects of phenytoin
AA Artru, JD Michenfelder
Stroke; a journal of cerebral circulation 1980
Studies on distribution and metabolism of valproate in rat brain, liver, and kidney
MI Aly, AA Abdel-Latif
Neurochemical Research 1980
Acetylcholine esterase sensitivity to chronic administration of diphenylhydantoin and effects on cerebral enzymatic activities related to energy metabolism
G Benzi, E Arrigoni, R Scelsi, F Marzatico, A Gorini, RF Villa
Neurochemical Research 1980
Neurotransmitters
Y Gutman
Neurotransmitters 1979
Effect of electric shock and diazepam on of Na, K-ATPase activity in brain membranes
RN Glebov, AM Golenda, GN Kryzhanovskii
Bulletin of Experimental Biology and Medicine 1979
Adenosine Triphosphatases of Rat Pancreatic Islets COMPARISON WITH THOSE OF RAT KIDNEY
SR Levin, BG Kasson, JF Driessen
Journal of Clinical Investigation 1978
Phenytoin application in murine muscular dystrophy: Behavioral improvement with no change in the abnormal intracellular Na : K ratio in skeletal muscles
H Silverman, HL Atwood, JW Bloom
Experimental Neurology 1978
Na+-K+-activated adenosinetriphosphatase as a trigger in transmitter release
ES Vizi
Neuroscience 1978
Neuropharmacology and Behavior
B Haber, MH Aprison
1978
The Role or Non-Role of ATPase Activation by Phenytoin in the Stabilization of Excitable Membranes
JD Deupree
Epilepsia 1977
The mechanism of action of diphenylhydantoin on invertebrate neurons. I. Effects on basic membrane properties
GF Ayala, S Lin, D Johnston
Brain Research 1977
Mechanism of inhibition of catecholamine release from adrenal medulla by diphenylhydantoin and by low concentration of ouabain (10?10 M)
Y Gutman, P Boonyaviroj
Naunyn-Schmiedeberg's Archives of Pharmacology 1977
Effects of anticonvulsant and convulsant drugs on the ATPase activities of synaptosomes and their components
JC Gilbert, MG Wyllie
British Journal of Pharmacology 1976
Evidence that diphenylhydantoin does not affect adenosine triphosphatases from brain
JD Deupree
Neuropharmacology 1976
Diphenylhydantoin increases cortical postsynaptic inhibition
W Raabe, GF Ayala
Brain Research 1976
Diphenylhydantoin facilitation of labile, protein-independent memory
ME Gibbs, KT Ng
Brain Research Bulletin 1976
EFFECTS OF ANTICONVULSANT AND CONVULSANT DRUGS ON THE ATPASE ACTIVITIES OF SYNAPTOSOMES AND THEIR COMPONENTS
J Gilbert, M Wyllie
British Journal of Pharmacology 1976
Dopamine—adaptive uptake changes in striatal synaptosomes after 30 sec of shock-induced fighting
MG Hadfield, WF Rigby
Biochemical Pharmacology 1976
XIIth I. S. C. E. R. G. Symposium
R Alfieri, P Solé
1976
Dynamics of Brain Edema
HM Pappius, W Feindel
1976
Pancreatic islet cells: electrogenic and electrodiffusional control of membrane potential
EK Mattews, Y Sakamoto
The Journal of Physiology 1975
Dilantin—Calcium interaction and active Na transport in frog skin
TG Riddle, LJ Mandel, MM Goldner
European Journal of Pharmacology 1975
The freezing lesion. III. The effects of diphenylhydantoin on potassium transport within nerve terminals from the primary foci
AV Escueta, D Davidson, G Hartwig, E Reilly
Brain Research 1975
Effect of fighting and diphenylhydantoin on the uptake of 3H-I-norepinephrine in vitro in synaptosomes isolated from retired male breeding mice
MG Hadheld, NE Weber
Biochemical Pharmacology 1975
Biochemical Pharmacology of Ethanol
E Majchrowicz
1975
Biology of Brain Dysfunction
GE Gaull
1975
Diphenylhydantoin: Action of a Common Anticonvulsant on Bursting Pacemaker Cells in Aplysia
D Johnston, GF Avala
Science 1975
Inhibition by Diphenylhydantoin of Vasopressin Release from Isolated Rat Neurohypophyses*
JW Guzek, JT Russell, NA Thorn
Acta Pharmacologica et Toxicologica 1974
The effects of certain anaesthetic and anti-convulsant drugs on the CSF potassium fluxes of the dog
J Halliday, AT Moir
British Journal of Pharmacology 1974
Proceedings: The effects of phenytoin on adenosine triphosphatase activities of synaptosomes and their components
JC Gilbert, MG Wyllie
British Journal of Pharmacology 1974
Endocrine manifestations of diphenylhydantoin therapy
H Gharib, JM Munoz
Metabolism 1974
Excitable membrane stabilization by diphenylhydantoin and calcium
L Carnay, S Grundfest
Neuropharmacology 1974
The effects of diphenylthiohydantoin on the membrane potentials of rat sensory nerve fibre bundles
W Grossmann, I Jurna
Neuropharmacology 1974
THE EFFECTS OF CERTAIN ANAESTHETIC AND ANTI-CONVULSANT DRUGS ON THE CSF POTASSIUM FLUXES OF THE DOG
J Halliday, A Moir
British Journal of Pharmacology 1974
Effects of diphenylhydantoin on coronary resistance and myocardial contractile force before and after ouabain
MP Doster, JB Scott
American Heart Journal 1974
DEVELOPMENT OF Na+-STIMULATED GLUCOSE OXIDATION IN SYNAPTOSOMES2
I Diamond, RA Fishman
Journal of Neurochemistry 1973
Transmission on an active electrical response between fibroblasts (L cells) in cell culture
PG Nelson, JH Peacock
The Journal of General Physiology 1973
Lack of effect of diphenylhydantoin administration on cortex potassium-activated p-nitrophenylphosphatase
E Lewin, JE Walker, V Bleck
Neuropharmacology 1973
Effects of ouabain and diphenylhydantoin on myocardial potassium balance in man
JL McCans, FJ Brennan, MA Chiong, JO Parker
The American Journal of Cardiology 1973
Anticonvulsant effect of 5-ethyl, 5-phenyl, 2-pyrrolidinone and its possible relationship to γ-aminobutyric acid-dependent inhibitory mechanisms
MP de la Mora, R Tapia
Biochemical Pharmacology 1973
Effects of diphenylhydantoin on transport processes in frog skin (Rana ridibunda)
RC de Sousa, A Grosso
Experientia 1973
Sodium-potassium-activated adenosine triphosphatase of brain microsomes: modification of sodium inhibition by diphenylhydantoins
GJ Siegel, BB Goodwin
Journal of Clinical Investigation 1972
Effect of diphenylhydantoin in ischemic optic neuritis
JL Keltner, B Becker, AJ Gay, SM Podos
Transactions of the American Ophthalmological Society 1972
The inhibitory effect of diphenylhydantoin on microsomal ATPases
AJ Wilensky, JA Lowden
Life Sciences 1972
Silent cells during interictal discharges and seizures in hippocampal penicillin foci. Evidence for the role of extracellular K+ in the transition from the interictal state to seizures
MA Dichter, CJ Herman, M Selzer
Brain Research 1972
Further studies of membrane atpase activity in muscular dystrophy erythrocytes
SK Chattopadhyay, HD Brown
International Journal of Biochemistry 1972
Diphenylhydantoin and movement of radioactive sodium into electrically stimulated cerebral slices
PD Swanson, PO Crane
Biochemical Pharmacology 1972
Effect of Diphenylhydantoin on Insulin Secretion in Man
C Malherbe, KC Burrill, SR Levin, JH Karam, PH Forsham
New England Journal of Medicine 1972
Inhibition by Diphenylhydantoin of Folic Acid Absorption in Man
CD Gerson, GW Hepner, N Brown, N Cohen, V Herbert, HD Janowitz
Gastroenterology 1972
Anticonvulsant Drugs1 I: Patho-physiological and Pharmacological Aspects
H Kutt, S Louis
Drugs 1972
Diphenylhydantoin and potassium transport in isolated nerve terminals
AV Escueta, SH Appel
Journal of Clinical Investigation 1971
Effects of diphenylhydantoin on the transport of Na+ and K+ and the regulation of sugar transport in muscle in vitro
I Bihler, PC Sawh
Biochimica et Biophysica Acta (BBA) - Biomembranes 1971
Effect of diphenylhydantoin on protein metabolism in the central nervous system
T Yanagihara, A Hamberger
Experimental Neurology 1971
The binding of diphenylhydantoin to brain and subcellular fractions
T Nielsen, C Cotman
European Journal of Pharmacology 1971
Diphenylhydantoin (Dilantin): stimulation of potassium influx in lobster axons
AP Fertziger, SE Liuzzi, PB Dunham
Brain Research 1971
Sodium- and potassium-activated ATPase of beef brain—Effects of some tranquilizers
I Ueda, T Wada, CM Ballinger
Biochemical Pharmacology 1971
MOTOR NERVE CONDUCTION VELOCITY DURING DIPHENYLHYDANTOIN INTOXICATION
E Birket-Smith, E Krogh
Acta Neurologica Scandinavica 1971
The in vitro inhibition of insulin secretion by diphenylhydantoin
JS Kizer, M Vargas-Gordon, K Brendel, R Bressler
Journal of Clinical Investigation 1970
Drugs, toxins and dietary amino acids affecting vitamin B12 or folic acid absorption or utilization
S Waxman, JJ Corcino, V Herbert
The American Journal of Medicine 1970
The action of phloridzin and sugars on (Na+−K+)-Activated ATPase
JS Britten, M Blank
The Journal of Membrane Biology 1969
Kinetic studies on a brain microsomal adenosine triphosphatase. II. Potassium-dependent phosphatase activity
JD Robinson
Biochemistry 1969
Biochemical studies of synapses in vitro. II. Potassium transport
AV Escueta, SH Appel
Biochemistry 1969
Biochemical Studies of Synapses in Vitro
SH Appel, L Autilio, BW Festoff, AV Escueta
The Journal of biological chemistry 1969
Medicinal Chemistry
WL Holmes
Medicinal Chemistry 1964

← Previous 1 2 3 4 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts