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Research Article Free access | 10.1172/JCI105923

The determination of total body exchangeable O2 stores

Carroll E. Cross, Bernard S. Packer, Michael Altman, J. Bernard L. Gee, H. Victor Murdaugh Jr., and Eugene D. Robin

1Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania 15213

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1Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania 15213

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1Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania 15213

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1Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania 15213

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1Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania 15213

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1Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania 15213

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Published October 1, 1968 - More info

Published in Volume 47, Issue 10 on October 1, 1968
J Clin Invest. 1968;47(10):2402–2410. https://doi.org/10.1172/JCI105923.
© 1968 The American Society for Clinical Investigation
Published October 1, 1968 - Version history
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Abstract

A method is described for the measurement of total body exchangeable oxygen stores (TBO2). It is based on the dilution of the stable oxygen isotope, 18O2, by the body exchangeable oxygen stores under circumstances in which 18O2 steady-state equilibrium was evaluated simultaneously for both arterial and venous blood compartments. After evaluation of several simplifying assumptions, TBO2 values in dog, normal man, and anemic patients were measured. The magnitude of the exchangeable nonlung oxygen stores was 11.0 ± 3.1 ml/kg (SD) in 5 dogs, 11.9 ± 2.1 ml/kg in 10 normal subjects, and 7.0 ± 1.6 ml/kg in 8 patients with severe anemia (hematocrits of 25% or less).

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