Citations to this article

Infectious mononucleosis: immunoglobulin synthesis by cell lines
Philip R. Glade, Lawrence N. Chessin
Philip R. Glade, Lawrence N. Chessin
Published October 1, 1968
Citation Information: J Clin Invest. 1968;47(10):2391-2401. https://doi.org/10.1172/JCI105922.
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Research Article

Infectious mononucleosis: immunoglobulin synthesis by cell lines

Abstract

Immunoglobulin synthesis by 16 long-term suspension cultures of mononuclear cells derived from peripheral blood of nine patients with heterophile-positive infectious mononucleosis (IM) has been demonstrated by radioimmunoelectrophoretic techniques. All cell lines synthesized molecules with IgG (γ) heavy chain specificity. 14 cell lines produced molecules with IgM (μ) heavy chain specificity and 11 cell lines produced molecules with IgA (α) heavy chain specificity. No detectable synthesis of molecules with IgD (δ) heavy chain specificity was observed by these cell lines derived from peripheral blood of patients with IM. 13 cell lines produced molecules with type K (κ) light chain specificity and 6 cell lines produced molecules with type L (λ) light chain specificity. Of interest, 9 of 16 lines produced IgG (γ), IgA (α), and IgM (μ) heavy chain molecules and 5 of these cell lines produced molecules with type K (κ) and type L (λ) light chain specificity as well.

Authors

Philip R. Glade, Lawrence N. Chessin

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Total citations by year

Year: 2011 1982 1979 1977 1976 1975 1974 1973 1972 1971 1970 1969 1968 Total
Citations: 1 1 1 1 2 3 4 2 2 2 2 2 1 24
Citation information

Citations to this article (24)

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Immunological Aspects of Allergy and Allergic Diseases
E Rajka, S Korossy 		1974
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Human lymphoid cell lines: Models for immunological analysis
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Progress in Immunology
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High-frequency establishment of human immunoglobulin-producing lymphoblastoid lines from normal and malignant lymphoid tissue and peripheral blood: HIGH-FREQUENCY ESTABLISHMENT OF HUMAN LYMPHOBLASTOID LINES
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Annotations
RK Chandra 		The Indian Journal of Pediatrics 1969
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