Citations to this article

Effects of guanidine derivatives on mitochondrial function: II. Reversal of guanidine-derivative inhibition by free fatty acids
Frank Davidoff
Frank Davidoff
Published October 1, 1968
Citation Information: J Clin Invest. 1968;47(10):2344-2358. https://doi.org/10.1172/JCI105919.
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Effects of guanidine derivatives on mitochondrial function: II. Reversal of guanidine-derivative inhibition by free fatty acids

Abstract

Long chain free fatty acids interfere with the inhibitory action of phenethylbiguanide and related compounds on mitochondrial respiration in vitro. This interference depends on binding of fatty acids to mitochondria and diminishes with decreasing chain length. Reversal of guanidine-derivative inhibition by fatty acids differs from that caused by dinitrophenol in that the effect of fatty acid is achieved without alteration in coupling or respiratory control. The binding of phenethylbiguanide to mitochondria is inhibited by both fatty acid and dinitrophenol. Serum albumin potentiates the inhibitory potency of guanidine derivatives, probably by removing endogenous mitochondrial free fatty acids.

Authors

Frank Davidoff

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Year: 2014 2013 2012 2010 1980 1977 1976 1975 1974 1972 1971 1968 Total
Citations: 2 2 1 1 1 1 1 1 1 3 2 1 17
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Citations to this article (17)

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P Strohfeldt, H Kettl, U Obermaier, KF Weinges 		Diabetologia 1975
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K Ogata, M Jomain-Baum, RW Hanson 		Biochemical Journal 1974
Effects of guanidine derivatives on mitochondrial function
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Effects of Guanidine Derivatives on Mitochondrial Function
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