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Research Article Free access | 10.1172/JCI105898

Regional distribution of acid mucopolysaccharides in the kidney

C. W. Castor and J. A. Greene

1Department of Internal Medicine, The University of Michigan and the Rackham Arthritis Research Unit, Ann Arbor, Michigan 48104

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1Department of Internal Medicine, The University of Michigan and the Rackham Arthritis Research Unit, Ann Arbor, Michigan 48104

Find articles by Greene, J. in: JCI | PubMed | Google Scholar

Published September 1, 1968 - More info

Published in Volume 47, Issue 9 on September 1, 1968
J Clin Invest. 1968;47(9):2125–2132. https://doi.org/10.1172/JCI105898.
© 1968 The American Society for Clinical Investigation
Published September 1, 1968 - Version history
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Abstract

Kidneys from 20 dogs were dissected into cortical and medullary components and analysed for acid mucopolysaccharide content. Heparitin sulfate accounted for approximately 80% of cortical acid mucopolysaccharide, 10% was chondroitin sulfate B, and 10% was low molecular weight hyaluronic acid. Medullary tissue exhibited a 4- to 5-fold higher concentration of acid mucopolysaccharide than did cortical tissue, and the dominant compound was moderately highly polymerized hyaluronic acid. While chondroitin sulfates A and (or) C were not detected in this study, the presence of minor amounts of these substances could not be excluded. A model experiment indicated that hyaluronic acid retards sodium diffusion, apparently due to its viscous properties rather than its electronegativity.

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