Citations to this article

Erythropoietic kinetics in sheep studied by means of induced changes in hemoglobin phenotype
Thomas G. Gabuzda, … , Ruth K. Silver, Hugh B. Lewis
Thomas G. Gabuzda, … , Ruth K. Silver, Hugh B. Lewis
Published August 1, 1968
Citation Information: J Clin Invest. 1968;47(8):1895-1904. https://doi.org/10.1172/JCI105880.
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Research Article

Erythropoietic kinetics in sheep studied by means of induced changes in hemoglobin phenotype

Abstract

This investigation is concerned with the kinetics of the reciprocal relationship between sheep hemoglobin (Hb) A and Hb C formation in response to anemia. The relative synthesis of the hemoglobin types was assessed at various times in bone marrow erythroid cells incubated in vitro with 59Fe. The changeover from Hb A to Hb C formation lagged by about 3 days behind the development of anemia and was complete within about 11 days. After recovery from anemia the reciprocal change back to preanemic conditions proceeded at a much slower rate, Hb C formation gradually declining to unmeasurable levels over about 25 days.

Authors

Thomas G. Gabuzda, Marc A. Schuman, Ruth K. Silver, Hugh B. Lewis

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Year: 2011 2008 2005 2002 1988 1980 1979 1977 1976 1975 1974 1973 1972 1971 1969 Total
Citations: 1 1 1 1 1 3 1 2 1 2 6 4 3 2 2 31
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Citations to this article (31)

Title and authors Publication Year
Advances in Clinical Chemistry
M Mahler 		Advances in Clinical Chemistry Volume 54 2011
Novartis Foundation Symposia: Ciba/Congenital
AW Nienhuis, JE Barker, A Deisseroth, WF Anderson 		Novartis Foundation Symposia: Ciba/Congenital 2008
Investigations of the induction of the goat βC globin gene by erythropoietin: Studies in transgenic mice
M Yu, Q Li, G Stamatoyannopoulos 		Blood Cells, Molecules, and Diseases 2005
Mechanisms Leading to Sustained Reversion of β-Thalassemia in Mice by Doxycycline-Controlled Epo Delivery from Muscles
S Samakoglu, D Bohl, JM Heard 		Molecular Therapy 2002
Kinetics of the Hb A to Hb C switch and erythropoietin plasma levels in sheep
R Vestri, A Crema, A Testa, O Lostia 		Animal Genetics 1988
Physiologic studies in normal and uremic sheep: II. Changes in erythropoiesis and oxygen transport
JW Eschbach, JC Detter, JW Adamson 		Kidney International 1980
Erythropoiesis in normal and mutant chick embryos
RW Keane, UK Abbott 		Developmental Biology 1980
The isolation of the beta A-, beta C-, and gamma-globin genes and a presumptive embryonic globin gene from a goat DNA recombinant library
JR Haynes, P Rosteck, EA Schon, PM Gallagher, DJ Burks, K Smith, JB Lingrel 		The Journal of biological chemistry 1980
The isolation and partial characterization of recombinant DNA containing genomic globin sequences from the goat
J Robbins, P Rosteck, JR Haynes, G Freyer, ML Cleary, HD Kalter, K Smith, JB Lingrel 		The Journal of biological chemistry 1979
Hemoglobin switching in sheep and goats: induction of hemoglobin C synthesis in cultures of sheep fetal erythroid cells
JE Barker, JE Pierce, BC Kefauver, AW Nienhuis 		Proceedings of the National Academy of Sciences 1977
Hemoglobin switching in sheep and goats. Preparation and characterization of complementary DNAs specific for the alpha-, beta-, and gamma-globin messenger RNAs of sheep
EJ Benz, CE Geist, AW Steggles, JE Barker, AW Nienhuis 		The Journal of biological chemistry 1977
Pathophysiology of Parasitic Infection
K Nielsen 		Pathophysiology of Parasitic Infection 1976
Hemoglobin switching in sheep and goats. V. Effect of erythropoietin concentration on in vitro erythroid colony growth and globin synthesis
JE Barker, WF Anderson, AW Nienhuis 		The Journal of Cell Biology 1975
The Blood of Sheep
MH Blunt 		1975
The Action of Erythropoietin on Erythroid Cells in vitro
RK Silver, AJ Erslev 		Scandinavian Journal of Haematology 1974
HEMOGLOBIN SWITCHING IN SHEEP AND GOATS: ASPECTS OF THE MOLECULAR MECHANISM
AW Nienhuis, NA Elson, JE Barker, WF Anderson 		Annals of the New York Academy of Sciences 1974
The Red Blood Cell
GJ Brewer 		The Red Blood Cell 1974
THE IN VIVO PRODUCTION OF HEMOGLOBIN C IN RUMINANTS
TH Huisman 		Annals of the New York Academy of Sciences 1974
THE A?C SWITCH IN SHEEP HEMOGLOBIN: IN VITRO STUDIES WITH ERYTHROPOIETIN
JW Adamson, G Stamatoyannopoulos 		Annals of the New York Academy of Sciences 1974
Hemoglobin Switching in Sheep and Goats: Occurrence of Hemoglobins A and C in the Same Red Cell
AW Nienhuis, HF Bunn 		Science 1974
Hemogloblin switching in sheep and goats: erythropoietin-dependent synthesis of hemoglobin C in goat bone-marrow cultures
JE Barker, JA Last, SL Adams, AW Nienhuis, WF Anderson 		Proceedings of the National Academy of Sciences 1973
The anemia-induced reversible switch from hemoglobin A to hemoglobin C in caprine ruminants: Immunochemical evidence that both hemoglobins are found in the same cell
MD Garrick, M Reichlin, M Mattioli, R Manning 		Developmental Biology 1973
Activation of Hemoglobin C Synthesis in Sheep Marrow Culture
JW Adamson, G Stamatoyannopoulos 		Science 1973
Fetal and embryonic haemoglobins
PA Lorkin 		Journal of medical genetics 1973
Duplication of haemoglobin genes
SR Hollán, RT Jones, RD Koler 		Biochimie 1972
THE CONTROL OF HAEMOGLOBIN SYNTHESIS
N Maclean, RD Jurd 		Biological Reviews 1972
Hemoglobin switching in sheep and goats: change in functional globin messenger RNA in reticulocytes and bone marrow cells
AW Nienhuis, WF Anderson 		Proceedings of the National Academy of Sciences 1972
Erythropoietin effects on fetal mouse erythroid cells. I. Cell population and hemoglobin synthesis
DH Chui, M Djaldetti, PA Marks, RA Rifkind 		The Journal of Cell Biology 1971
GENETIC VARIATION IN THE SHEEP RED BLOOD CELL
EM Tucker 		Biological reviews of the Cambridge Philosophical Society 1971
Hemoglobin and ferritin synthesis in erythroid cells in prolonged marrow cell cultures
TG Gabuzda, RK Silver, M Melvin, C Windus, C Sachs 		Journal of Cellular Physiology 1969
THE CONTROL OF HEMOGLOBIN PHENOTYPE IN CALVES AND SHEEP
TG Gabuzda, MA Schuman, RK Silver, HB Lewis 		Annals of the New York Academy of Sciences 1969

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