Effect of dietary fat on the fecal excretion of cholesterol and its degradation products in man

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Abstract

Fecal bile acid and neutral sterol excretion rates were determined in five healthy young men when serum cholesterol changes were induced by isocaloric substitution of an unsaturated (safflower oil) for a saturated fat (butter). The isotope balance method was used after the intravenous injection of cholesterol-4-14C. A feces extraction method is presented which permits essentially complete separation of fecal neutral sterols and bile acids.

Authors

Richard B. Moore, Joseph T. Anderson, Henry L. Taylor, Ancel Keys, Ivan D. Frantz Jr.