Citations to this article

ECHO-11 as a respiratory virus: quantitation of infection in man
Gilbert S. Saliba, … , Sylvia L. Franklin, George Gee Jackson
Gilbert S. Saliba, … , Sylvia L. Franklin, George Gee Jackson
Published June 1, 1968
Citation Information: J Clin Invest. 1968;47(6):1303-1313. https://doi.org/10.1172/JCI105822.
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Research Article

ECHO-11 as a respiratory virus: quantitation of infection in man

Abstract

Through a series of controlled experiments in volunteers, quantitative aspects of infection, illness, and immunity to ECHO-11 virus were studied. ECHO-11 is a transmissable viral infection in man and equally infectious to the upper respiratory and the intestinal tracts. The rate of infection was directly related to the dose of virus exposure, but any infectious dose of virus produced illness in only about one-third of the infected subjects. The infectious dose for man varied over a billionfold range. Larger challenge doses caused no difference in the local symptoms at the portal of entry or in the peak severity of illness, but symptoms were more diverse and prolonged after a higher dose. Persons with asymptomatic infections became just as heavily infected as ill persons.

Authors

Gilbert S. Saliba, Sylvia L. Franklin, George Gee Jackson

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Year: 2013 2012 2011 2003 1999 1995 1976 1969 Total
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Citations to this article (13)

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Minimum Infective Dose of the Major Human Respiratory and Enteric Viruses Transmitted Through Food and the Environment.
Yezli S, Otter JA 		Food and Environmental Virology 2011
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KD Mena 		Encyclopedia of Environmental Microbiology 2003
Bronchoalveolar lavage fluid cellularity and soluble intercellular adhesion molecule-1 in children with colds
J Grigg, J Riedler, CF Robertson 		Pediatric Pulmonology 1999
Human Enterovirus Infections
HA Rotbart 		1995
Entérovirus et infections respiratoires
JC Nicolas, JM Huraux 		Médecine et Maladies Infectieuses 1976
Infectious diseases. Annual review of significant publications
HA Reimann 		Postgraduate medical journal 1969
Infectious diseases. Annual review of significant publications.
Reimann HA 		Postgraduate medical journal 1969

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