Direct measurement of the rates of synthesis of plasma proteins in control subjects and patients with gastrointestinal protein loss
R. Dean Wochner, … , Delores Houston, Nathaniel I. Berlin
R. Dean Wochner, … , Delores Houston, Nathaniel I. Berlin
Published May 1, 1968
Citation Information: J Clin Invest. 1968;47(5):971-982. https://doi.org/10.1172/JCI105812.
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Research Article

Direct measurement of the rates of synthesis of plasma proteins in control subjects and patients with gastrointestinal protein loss

Abstract

The guanido carbon of hepatic arginine is the common precursor of urea and of the arginine of plasma proteins synthesized in the liver. It is possible to measure the momentary synthetic rates of plasma proteins by “pulse labeling” this arginine pool with bicarbonate-14C. In the current study, this method has been adapted in order to use urinary urea data and was applied to control subjects and patients with gastrointestinal protein loss. The assumptions required for this determination are discussed.

Authors

R. Dean Wochner, Sherman M. Weissman, Thomas A. Waldmann, Delores Houston, Nathaniel I. Berlin

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