Serum opsonin, bacteria, and polymorphonuclear leukocyte interactions in subacute bacterial endocarditis: <i>Anti-γ-globulin factors and their interaction with specific opsonins</i>

Ronald P. Messner; Throstur Laxdal; Paul G. Quie; Ralph C. Williams

doi:10.1172/JCI105800

^{Arthritis Unit, the Department of Medicine, University of Minnesota College of Medicine, University Hospitals, Minneapolis, Minnesota 55455}

^{Department of Pediatrics, University of Minnesota College of Medicine, University Hospitals, Minneapolis, Minnesota 55455}

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^{Arthritis Unit, the Department of Medicine, University of Minnesota College of Medicine, University Hospitals, Minneapolis, Minnesota 55455}

^{Department of Pediatrics, University of Minnesota College of Medicine, University Hospitals, Minneapolis, Minnesota 55455}

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^{Arthritis Unit, the Department of Medicine, University of Minnesota College of Medicine, University Hospitals, Minneapolis, Minnesota 55455}

^{Department of Pediatrics, University of Minnesota College of Medicine, University Hospitals, Minneapolis, Minnesota 55455}

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^{Arthritis Unit, the Department of Medicine, University of Minnesota College of Medicine, University Hospitals, Minneapolis, Minnesota 55455}

^{Department of Pediatrics, University of Minnesota College of Medicine, University Hospitals, Minneapolis, Minnesota 55455}

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Published in Volume 47, Issue 5 on May 1, 1968
J Clin Invest. 1968;47(5):1109–1120. https://doi.org/10.1172/JCI105800.
© 1968 The American Society for Clinical Investigation

Published May 1, 1968 - Version history

The effect of anti-γ-globulin factors on 7S γ-globulin opsonins from patients with subacute bacterial endocarditis has been examined with a quantitative in vitro phagocytosis system. Human anti-γ-globulin factors from patients with subacute bacterial endocarditis and rheumatoid arthritis inhibited the opsonic action of 7S γ-globulin specifically bound to bacteria. A similar antiopsonic effect was obtained with rabbit antiserum to human γG globulin. The antiopsonic effect of anti-γ-globulin factors did not correlate with their ability to potentiate agglutination of bacteria by 7S antibody. Competition was demonstrated between the antiopsonic effect of anti-γ-globulin factors and the phagocytosis-promoting action of heat-labile serum factors containing hemolytically active complement.