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Serum opsonin, bacteria, and polymorphonuclear leukocyte interactions in subacute bacterial endocarditis: Anti-γ-globulin factors and their interaction with specific opsonins
Ronald P. Messner, … , Paul G. Quie, Ralph C. Williams Jr.
Ronald P. Messner, … , Paul G. Quie, Ralph C. Williams Jr.
Published May 1, 1968
Citation Information: J Clin Invest. 1968;47(5):1109-1120. https://doi.org/10.1172/JCI105800.
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Serum opsonin, bacteria, and polymorphonuclear leukocyte interactions in subacute bacterial endocarditis: Anti-γ-globulin factors and their interaction with specific opsonins

Abstract

The effect of anti-γ-globulin factors on 7S γ-globulin opsonins from patients with subacute bacterial endocarditis has been examined with a quantitative in vitro phagocytosis system. Human anti-γ-globulin factors from patients with subacute bacterial endocarditis and rheumatoid arthritis inhibited the opsonic action of 7S γ-globulin specifically bound to bacteria. A similar antiopsonic effect was obtained with rabbit antiserum to human γG globulin. The antiopsonic effect of anti-γ-globulin factors did not correlate with their ability to potentiate agglutination of bacteria by 7S antibody. Competition was demonstrated between the antiopsonic effect of anti-γ-globulin factors and the phagocytosis-promoting action of heat-labile serum factors containing hemolytically active complement.

Authors

Ronald P. Messner, Throstur Laxdal, Paul G. Quie, Ralph C. Williams Jr.

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