The biological half-life of manganese and some factors influencing it have been studied in man. The disappearance of manganese from the body in normal subjects is described by a curve having two exponential components. An average of 70% of the injected material was eliminated by the “slow” pathway. The half-time characterizing this component showed a small variation in normal subjects and had an average value of 39 days. The half-time for the “fast” component also showed a small variation and had an average value of 4 days.
John P. Mahoney, Walter J. Small
Title and authors | Publication | Year |
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Incorporation of rapid association/dissociation processes in tissues into the monkey and human physiologically based pharmacokinetic models for manganese
Campbell JL, Clewell HJ III, Van Landingham C, Gentry PR, Keene AM, Taylor MD, Andersen ME |
Toxicological Sciences | 2022 |
Manganese salts function as potent adjuvants
R Zhang, C Wang, Y Guan, X Wei, M Sha, M Yi, M Jing, M Lv, W Guo, J Xu, Y Wan, XM Jia, Z Jiang |
Cellular and Molecular Immunology | 2021 |
Production of High-Purity 52 g Mn from nat V Targets with Alpha Beams at Cyclotrons
A Colombi, MP Carante, F Barbaro, L Canton, A Fontana |
NUCL TECHNOL | 2021 |
Colloidal Manganese Salt Improves the Efficacy of Rabies Vaccines in Mice, Cats, and Dogs
Z Wang, Y Yuan, C Chen, C Zhang, F Huang, M Zhou, H Chen, ZF Fu, L Zhao, MT Heise |
Journal of virology | 2021 |
Heavy Metals Exposure and Alzheimer’s Disease and Related Dementias
KM Bakulski, YA Seo, RC Hickman, D Brandt, HS Vadari, H Hu, SK Park |
Journal of Alzheimer's disease : JAD | 2020 |
Mechanisms of Co, Ni, and Mn toxicity: From exposure and homeostasis to their interactions with and impact on lipids and biomembranes
K Sule, J Umbsaar, EJ Prenner |
Biochimica et Biophysica Acta (BBA) - Biomembranes | 2020 |
Biomarkers of environmental manganese exposure and associations with childhood neurodevelopment: a systematic review and meta-analysis
W Liu, Y Xin, Q Li, Y Shang, Z Ping, J Min, CM Cahill, JT Rogers, F Wang |
Environmental Health | 2020 |
An Important Need to Monitor from an Early Age the Neurotoxins in the Blood or by an Equivalent Biomarker
K Schofield |
International journal of environmental research and public health | 2019 |
Radiation effective dose assessment of [51Mn]- and [52Mn]-chloride
LD Nardo, G Ferro-Flores, C Bolzati, J Esposito, L Meléndez-Alafort |
Applied Radiation and Isotopes | 2019 |
Anatomy, Functionality, and Neuronal Connectivity with Manganese Radiotracers for Positron Emission Tomography
G Saar, CM Millo, LP Szajek, J Bacon, P Herscovitch, AP Koretsky |
Molecular Imaging and Biology | 2018 |
Tooth manganese as a biomarker of exposure and body burden in rats
C Austin, C Richardson, D Smith, M Arora |
Environmental Research | 2017 |
Development and Evaluation of a Manganese and Iron Food Frequency Questionnaire for Pediatrics
F Zipkin, G Falciglia, P Kuhnell, E Haynes |
International journal of environmental research and public health | 2017 |
A tissue dose-based comparative exposure assessment of manganese using physiologically based pharmacokinetic modeling—The importance of homeostatic control for an essential metal
PR Gentry, CV Landingham, WG Fuller, SI Sulsky, TB Greene, HJ Clewell, ME Andersen, HA Roels, MD Taylor, AM Keene |
Toxicology and Applied Pharmacology | 2017 |
The application of PBPK models in estimating human brain tissue manganese concentrations
SP Ramoju, DR Mattison, B Milton, D McGough, N Shilnikova, HJ Clewell, M Yoon, MD Taylor, D Krewski, ME Andersen |
NeuroToxicology | 2017 |
Massive intravenous manganese overdose due to compounding error: minimal role for hemodialysis
EQ Hines, I Soomro, MA Howland, RS Hoffman, SW Smith |
Clinical Toxicology | 2016 |
Editor’s Highlight: Lower Fractional Anisotropy in the Globus Pallidus of Asymptomatic Welders, a Marker for Long-Term Welding Exposure
EY Lee, MR Flynn, G Du, MM Lewis, AH Herring, EV Buren, SV Buren, L Kong, RB Mailman, X Huang |
Toxicological Sciences | 2016 |
The critical fetal stage for maternal manganese exposure
MS Tsai, KW Liao, CH Chang, LC Chien, IF Mao, YA Tsai, ML Chen |
Environmental Research | 2015 |
Concentrations of strontium, barium, cadmium, copper, zinc, manganese, chromium, antimony, selenium, and lead in the liver and kidneys of dogs according to age, gender, and the occurrence of chronic kidney disease
N Paßlack, B Mainzer, M Lahrssen-Wiederholt, H Schafft, R Palavinskas, A Breithaupt, J Zentek |
Journal of Veterinary Science | 2015 |
Novel Preparation Methods of 52 Mn for ImmunoPET Imaging
SA Graves, R Hernandez, J Fonslet, CG England, HF Valdovinos, PA Ellison, TE Barnhart, DR Elema, CP Theuer, W Cai, RJ Nickles, GW Severin |
Bioconjugate Chemistry | 2015 |
Tailored biological retention and efficient clearance of pegylated ultra-small MnO nanoparticles as positive MRI contrast agents for molecular imaging
P Chevallier, A Walter, A Garofalo, I Veksler, J Lagueux, S Bégin-Colin, D Felder-Flesch, MA Fortin |
Journal of Materials Chemistry B | 2014 |
Accumulation of metals in GOLD4 COPD lungs is associated with decreased CFTR levels
F Hassan, X Xu, G Nuovo, DW Killilea, J Tyrrell, CD Tan, R Tarran, P Diaz, J Jee, D Knoell, PN Boyaka, E Cormet-Boyaka |
Respiratory Research | 2014 |
Concentrations of strontium, barium, cadmium, copper, zinc, manganese, chromium, antimony, selenium, and lead in the liver and kidneys of dogs according to age, gender, and the occurrence of chronic kidney disease.
Passlack N, Mainzer B, Lahrssen-Wiederholt M, Schafft H, Palavinskas R, Breithaupt A, Zentek J |
Journal of Veterinary Science | 2014 |
Manganese neurotoxicity and the role of reactive oxygen species
EJ Martinez-Finley, CE Gavin, M Aschner, TE Gunter |
Free radical biology & medicine | 2013 |
Manganese
D Milatovic, RC Gupta |
Veterinary Toxicology | 2012 |
Manganese in plasma: A promising biomarker of exposure to Mn in welders. A pilot study
P Hoet, E Vanmarcke, T Geens, G Deumer, V Haufroid, HA Roels |
Toxicology Letters | 2011 |
A biokinetic model for manganese
RW Leggett |
Science of The Total Environment | 2011 |
Welding and Parkinsonism
B Furbee |
Neurologic Clinics | 2011 |
Manganese Based MR Contrast Agents: Formulation and Clinical Applications
E Chabanova, VB Logager, JM Moller, HS Thomsen |
The Open Drug Safety Journal | 2011 |
Preliminary assessment of cardiac short term safety and efficacy of manganese chloride for cardiovascular magnetic resonance in humans
JL Fernandes, P Storey, JA da Silva, GS de Figueiredo, JM Kalaf, OR Coelho |
Journal of Cardiovascular Magnetic Resonance | 2011 |
Ontogenetic Exposure of Rats to Pre- and Post-Natal Manganese Enhances Behavioral Impairments Produced by Perinatal 6-Hydroxydopamine
P Nowak, K Bojanek, R Szkilnik, J Jośko, D Boroń, M Adwent, P Gorczyca, RM Kostrzewa, R Brus |
Neurotoxicity Research | 2010 |
Analysis of Manganese Tracer Kinetics and Target Tissue Dosimetry in Monkeys and Humans with Multi-Route Physiologically Based Pharmacokinetic Models
JD Schroeter, A Nong, M Yoon, MD Taylor, DC Dorman, ME Andersen, HJ Clewell |
Toxicological Sciences | 2010 |
Multi-Dose-Route, Multi-Species Pharmacokinetic Models for Manganese and Their Use in Risk Assessment
ME Andersen, DC Dorman, HJ Clewell, MD Taylor, A Nong |
Journal of Toxicology and Environmental Health, Part A | 2010 |
Myocardial infarction quantification with Manganese-Enhanced MRI (MEMRI) in mice using a 3T clinical scanner
BM Delattre, V Braunersreuther, JN Hyacinthe, LA Crowe, F Mach, JP Vallée |
NMR in Biomedicine | 2010 |
Chronic Exposure to Manganese Alters Brain Responses to Amphetamine: A Pharmacological Magnetic Resonance Imaging Study
JM Williams, D Milatovic, JC Gore, M Aschner, MJ Avison |
Toxicological Sciences | 2010 |
General and Applied Toxicology
TC Marrs, S Warren |
General and Applied Toxicology | 2009 |
Manganese Tissue Dosimetry in Rats and Monkeys: Accounting for Dietary and Inhaled Mn with Physiologically based Pharmacokinetic Modeling
A Nong, MD Taylor, HJ Clewell, DC Dorman, ME Andersen |
Toxicological Sciences | 2009 |
Modern Nutrition
K LaPoint, M McIntosh |
Handbook of Nutrition in the Aged, Fourth Edition | 2008 |
Modulation of cholinergic systems by manganese
Y Finkelstein, D Milatovic, M Aschner |
NeuroToxicology | 2007 |
Measuring Brain Manganese and Iron Accumulation in Rats following 14 Weeks of Low-Dose Manganese Treatment Using Atomic Absorption Spectroscopy and Magnetic Resonance Imaging
VA Fitsanakis, N Zhang, JG Anderson, KM Erikson, MJ Avison, JC Gore, M Aschner |
Toxicological Sciences | 2007 |
Biomarkers of Mn exposure in humans
D Smith, R Gwiazda, R Bowler, H Roels, R Park, C Taicher, R Lucchini |
American Journal of Industrial Medicine | 2007 |
Environmental, biochemical and molecular factors regulating manganese-induced neurological injury
JA Roth |
Journal of Organ Dysfunction | 2007 |
International Review of Neurobiology
ZT Bloomgarden |
International review of neurobiology | 2005 |
Nutritional aspects of manganese homeostasis
JL Aschner, M Aschner |
Molecular Aspects of Medicine | 2005 |
Manganese Dosimetry: Species Differences and Implications for Neurotoxicity
M Aschner, KM Erikson, DC Dorman |
Critical Reviews in Toxicology | 2005 |
Old age and gender influence the pharmacokinetics of inhaled manganese sulfate and manganese phosphate in rats
DC Dorman, BE McManus, MW Marshall, RA James, MF Struve |
Toxicology and Applied Pharmacology | 2004 |
Increased manganese concentration in the liver after oral intake1
H Thomsen |
Academic Radiology | 2004 |
Carcinogenicity, mutagenicity and teratogenicity of manganese compounds
GB Gerber, A Léonard, P Hantson |
Critical Reviews in Oncology/Hematology | 2002 |
Brain Manganese Concentrations in Rats Following Manganese Tetroxide Inhalation are Unaffected by Dietary Manganese Intake
DC Dorman, MF Struve, BA Wong |
NeuroToxicology | 2002 |
Influence of Particle Solubility on the Delivery of Inhaled Manganese to the Rat Brain: Manganese Sulfate and Manganese Tetroxide Pharmacokinetics Following Repeated (14-Day) Exposure
DC Dorman, MF Struve, RA James, MW Marshall, CU Parkinson, BA Wong |
Toxicology and Applied Pharmacology | 2001 |
The power of size. 2. Rate constants and equilibrium ratios for accumulation of inorganic substances related to species weight
AJ Hendriks, A Heikens |
Environmental Toxicology and Chemistry | 2001 |
Manganese-enhanced MRI of mouse heart during changes in inotropy
TC Hu, RG Pautler, GA MacGowan, AP Koretsky |
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine | 2001 |
Pharmacokinetics of Inhaled Manganese Phosphate in Male Sprague–Dawley Rats Following Subacute (14-Day) Exposure
D Vitarella, BA Wong, OR Moss, DC Dorman |
Toxicology and Applied Pharmacology | 2000 |
Manganese absorption and retention by young women is associated with serum ferritin concentration
JW Finley |
The American journal of clinical nutrition | 1999 |
Abnormalities in hair trace elements as indicators of aberrant behavior
LA Gottschalk, T Rebello, MS Buchsbaum, HG Tucker, EL Hodges |
Comprehensive Psychiatry | 1991 |
Trace element analysis of soil samples from a stratified archaeological site
JH Ottaway, MR Matthews |
Environmental Geochemistry and Health | 1988 |
Radioisotope-dilution technique for determining endogenous manganese in feces of the growing rat
E Weigand, U Helbig, M Kirchgessner |
Biological Trace Element Research | 1986 |
Effect of manganese on certain enzymes and constituents of blood and serum in rabbits. II
S Khandelwal, SK Tandon |
Environmental Research | 1981 |
Chronic ingestion of Mn<sub>3</sub>O<sub>4</sub> by young rats: Tissue accumulation, distribution, and depletion
GL Rehnberg, JF Hein, SD Carter, RS Linko, JW Laskey |
Journal of Toxicology and Environmental Health | 1981 |
Determination of urinary manganese by the direct chelation-extraction method and flameless atomic absorption spectrophotometry
T Watanabe, R Tokunaga, T Iwahana, M Tati, M Ikeda |
British journal of industrial medicine | 1978 |
Metabolic aspects of methylcyclopentadienyl manganese tricarbonyl in rats
W Moore, L Hall, W Crocker, J Adams, JF Stara |
Environmental Research | 1974 |
The Clinical Significance of the Essential Biological Metals
IJ Davies |
The Clinical Significance of the Essential Biological Metals | 1972 |
Distribution and fate of 54Mn in the monkey: studies of different parts of the central nervous system and other organs
DK Dastur, DK Manghani, KV Raghavendran |
Journal of Clinical Investigation | 1971 |
Einflu� der Ca-komplexe der aminopolycarbons�uren auf die ausscheidung und die verteilung des mangans bei der manganvergiftung
V Eybl, J S�kora |
Internationales Archiv f�r Gewerbepathologie und Gewerbehygiene | 1969 |